Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Neil Hapangama"'
Autor:
Swapan K. Chowdhury, Anima Ghosal, A.-D. Su, Shmuel Zbaida, Neil Hapangama, Yuan Yuan, Wei Tong
Publikováno v:
Drug Metabolism and Disposition. 34:628-635
Lonafarnib (Sarasar), a farnesyl transferase inhibitor, is currently under development for the treatment of solid tumors. Incubation of lonafarnib with human liver microsomes resulted in the formation of four oxidative metabolites (M1, M2, M3, and M4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bbb7edf69c2de28b69227de1aaaa54
https://doi.org/10.1124/dmd.105.007906
https://doi.org/10.1124/dmd.105.007906
Autor:
Swapan K. Chowdhury, Robert M. Iannucci, Kevin B. Alton, Neil Hapangama, Anima Ghosal, Yuan Yuan, James E. Patrick, Shmuel Zbaida, Joana Achanfuo-Yeboah
Publikováno v:
Drug Metabolism and Disposition. 32:314-320
Ezetimibe [1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone] (Zetia; Schering-Plough, Kenilworth, NJ) is the first in a new class of cholesterol-lowering agents known as cholesterol absorption inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a3f1555d40c814c045d0d01e1e2cbd
https://doi.org/10.1124/dmd.32.3.314
https://doi.org/10.1124/dmd.32.3.314
Autor:
Anima Ghosal, Ragu Ramanathan, Neil Hapangama, Swapan K. Chowdhury, Yuan Yuan, Kevin B. Alton, Narendra S. Kishnani
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(12)
Vicriviroc (SCH 417690), a CCR5 receptor antagonist, is currently under investigation for the treatment of human immunodeficiency virus infection. The objective of this study was to identify human liver cytochrome P450 enzyme(s) responsible for the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf88a493d5ed32030163a3d9a8ab3c0c
https://pubmed.ncbi.nlm.nih.gov/17827338
https://pubmed.ncbi.nlm.nih.gov/17827338
Autor:
Swapan K. Chowdhury, Yuan Yuan, Ai Duen Iris Su, James E. Patrick, Neil Hapangama, N. Alvarez, Kevin B. Alton, Shmuel Zbaida, Anima Ghosal
Publikováno v:
Biopharmaceuticsdrug disposition. 25(6)
Desloratadine is a non-sedating antihistamine recently approved for the treatment of seasonal allergic rhinitis. The major metabolite of desloratadine in human plasma and urine is the glucuronide conjugate of 3-hydroxydesloratadine. 3-Hydroxydeslorat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b16670f8ef77dbeb1aa515fcef5ecc
https://pubmed.ncbi.nlm.nih.gov/15334623
https://pubmed.ncbi.nlm.nih.gov/15334623
Autor:
Shmuel Zbaida, Robert M. Iannucci, Kevin B. Alton, Joana Achanfuo-Yeboah, Anima Ghosal, James E. Patrick, Neil Hapangama, Yuan Yuan, Swapan K. Chowdhury
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(2)
Posaconazole (Noxafil, SCH 56592), an orally available broad-spectrum triazole antifungal, is currently in phase III clinical studies for treating serious opportunistic fungal infections. The major in vitro metabolite of posaconazole formed by human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87ee1d6e23c4ee6af94c48d1809019a
https://pubmed.ncbi.nlm.nih.gov/14744950
https://pubmed.ncbi.nlm.nih.gov/14744950
Autor:
Xiaowen Lu, Debra Horne, James E. Patrick, Shmuel Zbaida, Anima Ghosal, Neil Hapangama, Yuan Yuan
Publikováno v:
Biopharmaceuticsdrug disposition. 24(9)
Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human cytochromes P450, human liver microsomes and human hepatocytes. Reproducible results were obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7aa4e0ef847032d98682d7cdad9273
https://pubmed.ncbi.nlm.nih.gov/14689466
https://pubmed.ncbi.nlm.nih.gov/14689466
Autor:
Anima Ghosal, Neil Hapangama, Yuan Yuan, Xiaowen Lu, Debra Horne, James E. Patrick, Shmuel Zbaida
Publikováno v:
Biopharmaceutics & Drug Disposition; Dec2003, Vol. 24 Issue 9, p375-384, 10p
Autor:
Anima, Ghosal, Neil, Hapangama, Yuan, Yuan, Joana, Achanfuo-Yeboah, Robert, Iannucci, Swapan, Chowdhury, Kevin, Alton, E, Patrick James, Shmuel, Zbaida
Publikováno v:
Drug Metabolism and Disposition; March 2004, Vol. 32 Issue: 3 p314-20, 7p
Autor:
Anima, Ghosal, Neil, Hapangama, Yuan, Yuan, Joana, Achanfuo-Yeboah, Robert, Iannucci, Swapan, Chowdhury, Kevin, Alton, E, Patrick James, Shmuel, Zbaida
Publikováno v:
Drug Metabolism and Disposition; February 2004, Vol. 32 Issue: 2 p267-71, 5p