Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Neil H. Segal"'
Autor:
Neil H. Segal, Ignacio Melero, Victor Moreno, Neeltje Steeghs, Aurelien Marabelle, Kristoffer Rohrberg, Maria E. Rodriguez-Ruiz, Joseph P. Eder, Cathy Eng, Gulam A. Manji, Daniel Waterkamp, Barbara Leutgeb, Said Bouseida, Nick Flinn, Meghna Das Thakur, Markus C. Elze, Hartmut Koeppen, Candice Jamois, Meret Martin-Facklam, Christopher H. Lieu, Emiliano Calvo, Luis Paz-Ares, Josep Tabernero, Guillem Argilés
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cibisatamab is a bispecific antibody-based construct targeting carcinoembryonic antigen (CEA) on tumour cells and CD3 epsilon chain as a T-cell engager. Here we evaluated cibisatamab for advanced CEA-positive solid tumours in two open-label
Externí odkaz:
https://doaj.org/article/c7ab25df143a4df7a0b711f295ef7d2c
Autor:
Chen Li, Ana Ferro, Shivani K. Mhatre, Danny Lu, Marcus Lawrance, Xiao Li, Shi Li, Simon Allen, Jayesh Desai, Marwan Fakih, Michael Cecchini, Katrina S. Pedersen, Tae You Kim, Irmarie Reyes-Rivera, Neil H. Segal, Christelle Lenain
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)
Li et al. report outcomes from the atezolizumab/isatuximab arm of the phase Ib/II MORPHEUS-CRC trial in patients with metastatic colorectal cancer. In addition, the authors leverage historical control data from the phase III IMblaze370 study to provi
Externí odkaz:
https://doaj.org/article/a2d8a6d7f97440f4b6e89b19aac1153c
Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer
Autor:
Rosa M. Jimenez-Rodriguez, Sujata Patil, Ajaratu Keshinro, Jinru Shia, Efsevia Vakiani, Zsofia Stadler, Neil H. Segal, Rona Yaeger, Tsuyoshi Konishi, Yoshifumi Shimada, Maria Widmar, Iris Wei, Emmanouil Pappou, J. Joshua Smith, Garrett Nash, Philip Paty, Julio Garcia-Aguilar, Martin R. Weiser
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Tumor infiltrating lymphocytes (TIL), which represent host adaptive response to the tumor, were first identified at scanning magnification to select areas with the highest counts on hematoxylin and eosin slides, quantitated per high-power field (HPF)
Externí odkaz:
https://doaj.org/article/e3b7505e7cd74e1fa57c3200bbd9c45f
Autor:
Julio Garcia-Aguilar, Sujata Patil, Marc J. Gollub, Jin K. Kim, Jonathan B. Yuval, Hannah M. Thompson, Floris S. Verheij, Dana M. Omer, Meghan Lee, Richard F. Dunne, Jorge Marcet, Peter Cataldo, Blase Polite, Daniel O. Herzig, David Liska, Samuel Oommen, Charles M. Friel, Charles Ternent, Andrew L. Coveler, Steven Hunt, Anita Gregory, Madhulika G. Varma, Brian L. Bello, Joseph C. Carmichael, John Krauss, Ana Gleisner, Philip B. Paty, Martin R. Weiser, Garrett M. Nash, Emmanouil Pappou, José G. Guillem, Larissa Temple, Iris H. Wei, Maria Widmar, Sabrina Lin, Neil H. Segal, Andrea Cercek, Rona Yaeger, J. Joshua Smith, Karyn A. Goodman, Abraham J. Wu, Leonard B. Saltz
Publikováno v:
Journal of Clinical Oncology. 40:2546-2556
PURPOSE Prospective data on the efficacy of a watch-and-wait strategy to achieve organ preservation in patients with locally advanced rectal cancer treated with total neoadjuvant therapy are limited. METHODS In this prospective, randomized phase II t
Autor:
Ajaratu Keshinro, Karuna Ganesh, Chad Vanderbilt, Canan Firat, Jin K. Kim, Chin-Tung Chen, Rona Yaeger, Neil H. Segal, Mithat Gonen, Jinru Shia, Zsofia K. Stadler, Martin R. Weiser
Publikováno v:
Diseases of the Colon & Rectum. 66:549-558
Autor:
Aurelien Marabelle, Sylvie Chevret, Pierre Saintigny, Luis A. Diaz, Assia Lamrani-Ghaouti, Clotilde Simon, Frederic Legrand, Natalie Hoog-Labouret, Andrea Cercek, Neil H. Segal, Anthony Ferrari, Severine Tabone-Eglinger, Asha R. Krishnan, Guillem Argiles, Bill H. Diplas, Steven B. Maron, Michelle F. Lamendola-Essel, Dennis Stephens, Drew G. Gerber, Stephane Champiat, Jean-Charles Soria, Christophe Tournigand, Stephane Oudard, Farid El Hajbi, Diane Pannier, Thierry Andre, Olivier Bouche, Esma Saada-Bouzid, Sandrine Hiret, Frederic Rolland, Aude Flechon, Christelle de la Fouchardiere, Sophie Cousin, Muriel Duluc, Jean-Jacques Grob, Marielle Guillet, Amandine Bruyas, Rosine Guimbaud, Carlos Gomez-Roca, Damien Pouessel, Antoine Hollebecque, David Malka, Paule Augereau, Victor Simmet, Romain Cohen, Magali Svrcek, Julien Masliah-Planchon, Michael B. Foote, Valerie Attignon, Aurelien de Reynies, Lucas Michon, Nicolas Leulliot, Nadim Hamzaoui, Eric Pasmant, Ivan Bieche, Benoit Rousseau
Supplementary Figure from PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68c6d0639646b5d1548ca8532028d21
https://doi.org/10.1158/2159-8290.22541047.v1
https://doi.org/10.1158/2159-8290.22541047.v1
Autor:
Aurelien Marabelle, Sylvie Chevret, Pierre Saintigny, Luis A. Diaz, Assia Lamrani-Ghaouti, Clotilde Simon, Frederic Legrand, Natalie Hoog-Labouret, Andrea Cercek, Neil H. Segal, Anthony Ferrari, Severine Tabone-Eglinger, Asha R. Krishnan, Guillem Argiles, Bill H. Diplas, Steven B. Maron, Michelle F. Lamendola-Essel, Dennis Stephens, Drew G. Gerber, Stephane Champiat, Jean-Charles Soria, Christophe Tournigand, Stephane Oudard, Farid El Hajbi, Diane Pannier, Thierry Andre, Olivier Bouche, Esma Saada-Bouzid, Sandrine Hiret, Frederic Rolland, Aude Flechon, Christelle de la Fouchardiere, Sophie Cousin, Muriel Duluc, Jean-Jacques Grob, Marielle Guillet, Amandine Bruyas, Rosine Guimbaud, Carlos Gomez-Roca, Damien Pouessel, Antoine Hollebecque, David Malka, Paule Augereau, Victor Simmet, Romain Cohen, Magali Svrcek, Julien Masliah-Planchon, Michael B. Foote, Valerie Attignon, Aurelien de Reynies, Lucas Michon, Nicolas Leulliot, Nadim Hamzaoui, Eric Pasmant, Ivan Bieche, Benoit Rousseau
Supplementary Data from PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a66d609cc79fa4d01bedd59b08afcf
https://doi.org/10.1158/2159-8290.22541062
https://doi.org/10.1158/2159-8290.22541062
Autor:
Aurelien Marabelle, Sylvie Chevret, Pierre Saintigny, Luis A. Diaz, Assia Lamrani-Ghaouti, Clotilde Simon, Frederic Legrand, Natalie Hoog-Labouret, Andrea Cercek, Neil H. Segal, Anthony Ferrari, Severine Tabone-Eglinger, Asha R. Krishnan, Guillem Argiles, Bill H. Diplas, Steven B. Maron, Michelle F. Lamendola-Essel, Dennis Stephens, Drew G. Gerber, Stephane Champiat, Jean-Charles Soria, Christophe Tournigand, Stephane Oudard, Farid El Hajbi, Diane Pannier, Thierry Andre, Olivier Bouche, Esma Saada-Bouzid, Sandrine Hiret, Frederic Rolland, Aude Flechon, Christelle de la Fouchardiere, Sophie Cousin, Muriel Duluc, Jean-Jacques Grob, Marielle Guillet, Amandine Bruyas, Rosine Guimbaud, Carlos Gomez-Roca, Damien Pouessel, Antoine Hollebecque, David Malka, Paule Augereau, Victor Simmet, Romain Cohen, Magali Svrcek, Julien Masliah-Planchon, Michael B. Foote, Valerie Attignon, Aurelien de Reynies, Lucas Michon, Nicolas Leulliot, Nadim Hamzaoui, Eric Pasmant, Ivan Bieche, Benoit Rousseau
Missense mutations in the polymerase epsilon (POLE) gene have been reported to generate proofreading defects resulting in an ultramutated genome and to sensitize tumors to checkpoint blockade immunotherapy. However, many POLE-mutated tumors do not re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a36140e69ccd60ecf121a937d16ebe
https://doi.org/10.1158/2159-8290.c.6549541
https://doi.org/10.1158/2159-8290.c.6549541
Autor:
Al B. Benson, Sharyn Worrall, Keavy McAbee, Anjelica Q. Davis, Nancy Roach, Jill O'Donnell-Tormey, Edward Cha, Rebecca A. Moss, Arvin Yang, Neil H. Segal, Cynthia L. Sears, Wells Messersmith, Christopher H. Lieu, Smitha S. Krishnamurthi, S. Peter Kang, Elizabeth M. Jaffee, Franck Housseau, Stanley R. Hamilton, Richard M. Goldberg, Wolf H. Fridman, Luis A. Diaz, Dustin A. Deming, Emily Chan, Arthur N. Brodsky, Thomas H. Marsilje, Andrea Dwyer, Christopher R. Heery, Michael A. Morse, Vanessa M. Hubbard-Lucey, Dung T. Le
Immunotherapy is rapidly becoming a standard of care for many cancers. However, colorectal cancer had been generally resistant to immunotherapy, despite features in common with sensitive tumors. Observations of substantial clinical activity for check
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fe819a9579ba657dff6e159f30b6a62
https://doi.org/10.1158/2326-6066.c.6548287.v1
https://doi.org/10.1158/2326-6066.c.6548287.v1
Autor:
Al B. Benson, Sharyn Worrall, Keavy McAbee, Anjelica Q. Davis, Nancy Roach, Jill O'Donnell-Tormey, Edward Cha, Rebecca A. Moss, Arvin Yang, Neil H. Segal, Cynthia L. Sears, Wells Messersmith, Christopher H. Lieu, Smitha S. Krishnamurthi, S. Peter Kang, Elizabeth M. Jaffee, Franck Housseau, Stanley R. Hamilton, Richard M. Goldberg, Wolf H. Fridman, Luis A. Diaz, Dustin A. Deming, Emily Chan, Arthur N. Brodsky, Thomas H. Marsilje, Andrea Dwyer, Christopher R. Heery, Michael A. Morse, Vanessa M. Hubbard-Lucey, Dung T. Le
Supplemental Tables 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707eae64e6122a01edf458348b5685d3
https://doi.org/10.1158/2326-6066.22536955.v1
https://doi.org/10.1158/2326-6066.22536955.v1