Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

Autor: Neil H. Bagnall, Barney M. Hines, Andrew J. Lucke, Praveer K. Gupta, Robert C. Reid, David P. Fairlie, Andrew C. Kotze

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 1, Pp 51-60 (2017)

Histone deacetylase inhibitors (HDACi) are being investigated for the control of various human parasites. Here we investigate their potential as insecticides for the control of a major ecto-parasite of sheep, the Australian sheep blowfly, Lucilia cup

Externí odkaz: https://doaj.org/article/4c5b7df6571641498a53ac7347ffe785

Effects of in vitro exposure to ivermectin and levamisole on the expression patterns of ABC transporters in Haemonchus contortus larvae

Autor: Ali Raza, Steven R. Kopp, Neil H. Bagnall, Abdul Jabbar, Andrew C. Kotze

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 2, Pp 103-115 (2016)

This study investigated the interaction of ATP binding cassette (ABC) transport proteins with ivermectin (IVM) and levamisole (LEV) in larvae of susceptible and resistant isolates of Haemonchus contortus in vitro by measuring transcription patterns f

Externí odkaz: https://doaj.org/article/26c28ed23cc049679218a69940d936e3

Mutations in the Hco-mptl-1 gene in a field-derived monepantel-resistant isolate of Haemonchus contortus

Autor: Jane Lamb, Timothy P. Elliott, Angela P. Ruffell, Andrew C. Kotze, Ali Raza, Neil H. Bagnall, Peter W. Hunt

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 2, Pp 236-240 (2017)
International Journal for Parasitology: Drugs and Drug Resistance

Resistance to the anthelmintic drug monepantel (Zolvix®) has emerged in parasitic worms infecting sheep and goats. The mechanism of resistance in these cases is unknown. The drug targets nicotinic acetylcholine receptors belonging to the nematode-sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1fe2d2a683627881bbd776e466eada
http://www.sciencedirect.com/science/article/pii/S2211320717300246

Cloning, recombinant expression and inhibitor profiles of dihydrofolate reductase from the Australian sheep blow fly,Lucilia cuprina

Autor: Roger Pearson, Neil H. Bagnall, Angela P. Ruffell, Andrew C. Kotze

Publikováno v: Medical and Veterinary Entomology. 28:297-306

While dihydrofolate reductase (DHFR) is an important drug target in mammals, bacteria and protozoa, no inhibitors of this enzyme have been developed as commercial insecticides. We therefore examined the potential of this enzyme as a drug target in an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d31038cb4b67abca6912dbfbf25b285f
https://doi.org/10.1111/mve.12041

Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitro

Autor: Ali Raza, Andrew C. Kotze, Abdul Jabbar, Neil H. Bagnall, Steven Kopp

Publikováno v: Parasites & Vectors

Background There is some evidence that ATP binding cassette (ABC) transporters play a role in resistance to anthelmintics, particularly against macrocyclic lactones. Some anthelmintics, including ivermectin (IVM), have been shown to induce transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952a58c765f84969c9fe7aa0c894766f
http://europepmc.org/articles/PMC5041279