Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Neil Gregory Almstead"'
Autor:
Neil Gregory Almstead, Marcio Souza, Joseph McIntosh, Oscar L. Laskin, Ronald Kong, Diksha Kaushik, Jiyuan Ma, Fengbin Jin
Publikováno v:
Clinical Pharmacology in Drug Development
To evaluate the potential for ethnicity‐related differences in ataluren pharmacokinetics (PK) and safety, a phase 1 single‐dose study was conducted in 48 healthy (24 Japanese and 24 Caucasian subjects), nonsmoking male volunteers who were equally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08765ddfdf17d3fb43af875013c67086
https://doi.org/10.1002/cpdd.645
https://doi.org/10.1002/cpdd.645
Autor:
Jiyuan Ma, Thomas W. Davis, Young-Choon Moon, Hongyan Qi, Stuart W. Peltz, Janet Petruska, Neil Gregory Almstead, Nicole Risher, Art Branstrom, Jean Hedrick, Seongwoo Hwang, Katherine Cintron, William Joseph Lennox, Charles M. Romfo, Tamil Arasu, Liangxian Cao, Josephine Sheedy, John Babiak, Min Jung Kim, Ronald Kong, Wencheng Li, Jason D. Graci, Allan Jacobson, Shirley Yeh, Christopher R. Trotta, Joshua Du, Joseph M. Colacino, Bansri Furia, Marla Weetall
Publikováno v:
Molecular Cancer Therapeutics. 18:3-16
PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc21306fbe053e0ead2cdd503bd008ff
https://doi.org/10.1158/1535-7163.mct-18-0863
https://doi.org/10.1158/1535-7163.mct-18-0863
Autor:
Ronald Kong, Ellen Welch, Elizabeth Goodwin, John Babiak, Marla Weetall, Joseph M. Colacino, Young-Choon Moon, Neil Gregory Almstead, Jiyuan Ma, Seongwoo Hwang
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b11a17e98683df4b0e4b362c157b1fb
https://doi.org/10.1002/prp2.576
https://doi.org/10.1002/prp2.576
Autor:
Woll Matthew G, Marla Weetall, Jiashi Wang, Sean M. Smith, Arthur Branstrom, Aleksey I. Gerasyuto, Neil Gregory Almstead, Xiaoyan Zhang, Srinivasa Peddi, Guangming Chen, J V N Prasad, Nanjing Zhang, Jana Narasimhan, Josephine Sheedy, Michael Arnold, Melissa Dumble, Gary Mitchell Karp, John D. Baird
Publikováno v:
Journal of Medicinal Chemistry
There exists an urgent medical need to identify new chemical entities (NCEs) targeting multidrug resistant (MDR) bacterial infections, particularly those caused by Gram-negative pathogens. 4-Hydroxy-2-pyridones represent a novel class of nonfluoroqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89561326bd58f358c6ca6cbf2e9f7532
https://doi.org/10.1021/acs.jmedchem.8b00114
https://doi.org/10.1021/acs.jmedchem.8b00114
Autor:
Neil Gregory Almstead, Joseph M. Colacino, Nicole Risher, Valerie Northcutt, Ronald Kong, Ellen Welch, Jiyuan Ma, Young-Choon Moon, Marla Weetall
Publikováno v:
Drug Metabolism and Pharmacokinetics. 38:100393
Ataluren is an aromatic acid derivative with a 1,2,4-oxodiazole moiety. Ataluren-O-1β-acyl glucuronide is a prominent circulatory metabolite in mice, rats, dogs, and humans following oral administration of ataluren. The objective of this paper was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05204623d2470727182d6349aa73f196
https://doi.org/10.1016/j.dmpk.2021.100393
https://doi.org/10.1016/j.dmpk.2021.100393
Autor:
Elizabeth Goodwin, Valerie Northcutt, Neil Gregory Almstead, Joseph McIntosh, Ronald Kong, Seongwoo Hwang, John Babiak, Jiyuan Ma
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(4)
Ataluren is a unique small molecule developed for the treatment of diseases caused by nonsense mutations, which result in premature termination of ribosomal translation and lack of full-length protein production. This study investigated the in vivo m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cb380bc24dad9696f3e5743cd1a33b
https://pubmed.ncbi.nlm.nih.gov/31980502
https://pubmed.ncbi.nlm.nih.gov/31980502
Autor:
Young-Choon Moon, Marla Weetall, R. Spiegel, Stuart W. Peltz, Samit Hirawat, Neil Gregory Almstead, John Babiak, Liangxian Cao, Valerie Northcutt, Peter Riebling, Joseph M. Colacino, Mandar V. Dali, Thomas W. Davis, Gary Elfring
Publikováno v:
Clinical Pharmacology in Drug Development
PTC299 is a novel small molecule that specifically blocks the production of protein from selected mRNAs that under certain conditions use noncanonical ribosomal translational pathways. Hypoxia, oncogenic transformation, and viral infections limit nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c9b02748d1f5ce68203dfe0359fb55
http://europepmc.org/articles/PMC5066743
http://europepmc.org/articles/PMC5066743
Autor:
Song Huang, Jason D. Graci, Paul Ingravallo, Anthony Turpoff, Neil Gregory Almstead, John Pichardo, Nanjing Zhang, Joseph M. Colacino, F. George Njoroge, Yalei Liu, Zhengxian Gu, Marla Weetall, Frederick C. Lahser, Stephen P. Jung, Gary Mitchell Karp, Amin A. Nomeir, Xiaoyan Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:594-601
A novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides was identified and optimized for activity against the HCV genotype 1b replicon resulting in compounds with potent and selective activity. Further evaluation of this series demonstrated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f2dde02f0aa0ffaf8e4d127e01fcf0
https://doi.org/10.1016/j.bmcl.2015.11.065
https://doi.org/10.1016/j.bmcl.2015.11.065
Autor:
Jiashi Wang, John D. Baird, Neil Gregory Almstead, Marla Weetall, Yi Jin Kim Gorske, Jean Hedrick, Jana Narasimhan, Aleksey I. Gerasyuto, Tamil Arasu, Srinivasa Peddi, Wu Du, Michael Arnold, Josephine Sheedy, Gary Mitchell Karp, Stanley W. Lue, Guy Lagaud, Arthur Branstrom, J. V. N. Vara Prasad, Ginzburg Olya
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(22)
The continued emergence of bacteria resistant to current standard of care antibiotics presents a rapidly growing threat to public health. New chemical entities (NCEs) to treat these serious infections are desperately needed. Herein we report the disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b816934842e2deccf43233dd9921a40
https://pubmed.ncbi.nlm.nih.gov/29032026
https://pubmed.ncbi.nlm.nih.gov/29032026
Autor:
Chien-Ping Ko, Luca Santarelli, Hasane Ratni, Roland Schmucki, Maureen S. Lynes, Josephine Sheedy, Sergey Paushkin, Chang-Sun Lee, Irene Gerlach, Jesse L. Mull, Nanjing Zhang, Zhihua Feng, Anthony Turpoff, Anuradha Bhattacharyya, Paulo Fontoura, Priya Vazirani, Panayiota Trifillis, Gary Mitchell Karp, Joseph M. Colacino, Martin Ebeling, Kathleen D. McCarthy, John Babiak, Woll Matthew G, Hongyan Qi, Nikolai Naryshkin, Manaswini Sivaramakrishnan, Lee L. Rubin, Jana Narasimhan, Neil Gregory Almstead, Vijayalakshmi Gabbeta, Amal Dakka, Loren A. Eng, Xin Zhao, Nicole Risher, Young-Choon Moon, Marla Weetall, Jiyuan Ma, Karen K. Y. Ling, Stuart W. Peltz, Ellen Welch, Friedrich Metzger, Guangming Chen, Bansri Furia, Daniel Haehnke, Ronald Kong, Anirvan Ghosh, Xiaoyan Zhang, Karen S. Chen
Publikováno v:
Science. 345:688-693
Drugs that provide the splice of life Motor neurons relay signals from the nervous system to muscle fibers. In patients with spinal muscular atrophy, a protein required for the survival of these neurons is deficient or missing altogether, so the neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee00322a0f82a8e7897ded171950628b
https://doi.org/10.1126/science.1250127
https://doi.org/10.1126/science.1250127