Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Neil Gozzard"'
Autor:
Alan J. Hayes, Sanket Rane, Hannah E. Scales, Gavin R. Meehan, Robert A. Benson, Asher Maroof, Juliane Schroeder, Michio Tomura, Neil Gozzard, Andrew J. Yates, Paul Garside, James M. Brewer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Initiation of adaptive immunity involves distinct migratory cell populations coming together in a highly dynamic and spatially organized process. However, we lack a detailed spatiotemporal map of these events due to our inability to track the fate of
Externí odkaz:
https://doaj.org/article/990e096a122f42f8ab6e7b00751d7cba
Autor:
Akul Singhania, Hitasha Rupani, Nivenka Jayasekera, Simon Lumb, Paul Hales, Neil Gozzard, Donna E Davies, Christopher H Woelk, Peter H Howarth
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168680 (2017)
Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, wi
Externí odkaz:
https://doaj.org/article/dfeb7c410dfd43f6b476ae9e263705dc
Autor:
Neil Gozzard, Robert A. Benson, James M. Brewer, Andrew J. Yates, Sanket Rane, Juliane Schroeder, Paul Garside, Hannah E. Scales, Alan J. Hayes, Gavin R. Meehan, Michio Tomura, Asher Maroof
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Initiation of adaptive immunity involves distinct migratory cell populations coming together in a highly dynamic and spatially organized process. However, we lack a detailed spatiotemporal map of these events due to our inability to track the fate of
Autor:
Jörgen Östling, Marleen van Geest, James P.R. Schofield, Zala Jevnikar, Susan Wilson, Jonathan Ward, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R. Sousa, Yike Guo, Ian M. Adcock, Peter Howarth, Kian Fan Chung, Jeanette Bigler, Peter J. Sterk, Paul J. Skipp, Ratko Djukanović, Outi Vaarala, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, K.F. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powell, G. Praticò, M. Puig N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Antonios Aliprantis, David Allen, Kjell Alving, P. Badorrek, David Balgoma, S. Ballereau, Clair Barber, Manohara Kanangana Batuwitage, A. Bautmans, A. Bedding, A.F. Behndig, Jorge Beleta, A. Berglind, A. Berton, Grazyna Bochenek, Armin Braun, D. Campagna, Leon Carayannopoulos, C. Casaulta, Romanas Chaleckis, B. Dahlén, imothy Davison, Jorge De Alba, Inge De Lepeleire, Tamara Dekker, Ingrid Delin, P. Dennison, Annemiek Dijkhuis, Paul Dodson, Aleksandra Draper, K. Dyson, Jessica Edwards, L. El Hadjam, Rosalia Emma, Magnus Ericsson, C. Faulenbach, Breda Flood, G. Galffy, Hector Gallart, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Cristina Gomez, Kerry Gove, Neil Gozzard, E. Guillmant-Farry, E. Henriksson, Lorraine Hewitt, U. Hoda, Richard Hu, Sile Hu, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Juliette Kamphuis, Erika J. Kennington, Dyson Kerry, G. Kerry, M. Klüglich, Hugo Knobel, Johan Kolmert, J.R. Konradsen, Maxim Kots, Kosmas Kretsos, L. Krueger, Scott Kuo, Maciej Kupczyk, Bart Lambrecht, A.-S. Lantz, Christopher Larminie, L.X. Larsson, P. Latzin, N. Lazarinis, N. Lemonnier, Saeeda Lone-Latif, L.A. Lowe, Alexander Manta, Lisa Marouzet, Jane Martin, Caroline Mathon, L. McEvoy, Sally Meah, A. Menzies-Gow, Leanne Metcalf, Maria Mikus, Philip Monk, Shama Naz, K. Nething, Ben Nicholas, U. Nihlén, Peter Nilsson, R. Niven, B. Nordlund, S. Nsubuga, Antonio Pacino, Susanna Palkonen, J. Pellet, Giorgio Pennazza, Anne Petrén, Sandy Pink, C. Pison, Anthony Postle, Malayka Rahman-Amin, Lara Ravanetti, Emma Ray, Stacey Reinke, Leanne Reynolds, K. Riemann, Martine Robberechts, J.P. Rocha, C. Rossios, Kirsty Russell, Michael Rutgers, G. Santini, Marco Santoninco, M. Saqi, Corinna Schoelch, S. Scott, N. Sehgal, Marcus Sjödin, Barbara Smids, Caroline Smith, Jessica Smith, Katherine M. Smith, P. Söderman, A. Sogbessan, F. Spycher, Doroteya Staykova, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, John-Olof Thörngren, Jonathan Thorsen, S. Valente, Marianne van de Pol, C.M. van Drunen, Jonathan Van Eyll, Jenny Versnel, Anton Vink, C. von Garnier, A. Vyas, Frans Wald, Samantha Walker, Kristiane Wetzel, Coen Wiegman, Siân Williams, Xian Yang, Elizabeth Yeyasingham, W. Yu Amgen, W. Zetterquist, Z. Zolkipli, A.H. Zwinderman
Publikováno v:
Journal of Allergy and Clinical Immunology, 144(5), 1198-1213. Mosby Inc.
U-BIOPRED Study Group 2019, ' IL-17-high asthma with features of a psoriasis immunophenotype ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2019.03.027
Journal of allergy and clinical immunology, 144(5), 1198-1213. Mosby Inc.
Östling, J R, van Geest, M, U-BIOPRED Study Group, Schofield, J P R, Jevnikar, Z, Wilson, S, Ward, J, Lutter, R, Shaw, D E, Bakke, P S, Caruso, M, Dahlen, S-E, Fowler, S J, Horváth, I, Krug, N, Montuschi, P, Sanak, M, Sandström, T, Sun, K, Pandis, I, Auffray, C, Sousa, A R, Guo, Y, Adcock, I M, Howarth, P, Chung, K F, Bigler, J, Sterk, P J, Skipp, P J, Djukanović, R & Vaarala, O 2019, ' IL-17–high asthma with features of a psoriasis immunophenotype ', Journal of Allergy and Clinical Immunology, vol. 144, no. 5, pp. 1198-1213 . https://doi.org/10.1016/j.jaci.2019.03.027
U-BIOPRED Study Group 2019, ' IL-17-high asthma with features of a psoriasis immunophenotype ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2019.03.027
Journal of allergy and clinical immunology, 144(5), 1198-1213. Mosby Inc.
Östling, J R, van Geest, M, U-BIOPRED Study Group, Schofield, J P R, Jevnikar, Z, Wilson, S, Ward, J, Lutter, R, Shaw, D E, Bakke, P S, Caruso, M, Dahlen, S-E, Fowler, S J, Horváth, I, Krug, N, Montuschi, P, Sanak, M, Sandström, T, Sun, K, Pandis, I, Auffray, C, Sousa, A R, Guo, Y, Adcock, I M, Howarth, P, Chung, K F, Bigler, J, Sterk, P J, Skipp, P J, Djukanović, R & Vaarala, O 2019, ' IL-17–high asthma with features of a psoriasis immunophenotype ', Journal of Allergy and Clinical Immunology, vol. 144, no. 5, pp. 1198-1213 . https://doi.org/10.1016/j.jaci.2019.03.027
Background The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective We sought to undertake a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924ef083d27395d6795993c461f0cec8
https://publica.fraunhofer.de/handle/publica/259279
https://publica.fraunhofer.de/handle/publica/259279
Autor:
Neus Prats, Montserrat Miralpeix, Neil Gozzard, Jorge De Alba, Anna Domènech, Raquel Otal, Elena Calama
Publikováno v:
Clinical Science. 129:973-987
RNA viruses are a major cause of respiratory infections and are known to exacerbate asthma and other respiratory diseases. Our aim was to test the ability of poly(I:C) (polyinosinic:polycytidylic acid), a viral surrogate, to elicit exacerbation in a
Autor:
A. Gilmour, S Schwank, Frederic Geissmann, Christopher M Mela, B Kola, B Harvey, I Vranic, Evan Tzanis, H-D Zucht, Peter C. Taylor, J Diboll, Alexandra Belson, G Molyneux, MA Sleeman, Rekha Parmar, E Vernon, Stephen P. Young, Iona Donnelly, C Cuff, P Schulz-Knappe, Heidi Lempp, Christopher D. Buckley, N Payne, John D. Isaacs, Coziana Ciurtin, H Noble, M Macoritto, A Parke, S Jelinsky, James N. Galloway, Ian C. Scott, Frederique Ponchel, Sarah Keidel, Denny Verbeeck, A Didierlaurent, MF McDermot, J Tarn, AT Virlan, T Lazarov, J Ellis, S Kaymakcalan, Anthony Rowe, Catharien M. U. Hilkens, G Altobelli, M Loza, P Jones, Ayako Wakatsuki Pedersen, Ian N. Bruce, Duncan Porter, A Cuza, D Ziemek, S Talbot, C Marshall, A Herath, D Finch, D Baker, Maya H Buch, Y Zhong, R Toward, Ludbrook, Mark Coles, Barnes, M Ho, M Page, J Casement, M Maciejewski, Claudio Carini, Sarah Brockbank, D Nguyen, H Tipney, A Filer, Christopher R. John, S Kelly, Andrew P. Cope, W Burny, M Curran, Catharina Lindholm, Benjamin A Fisher, Ray Harris, Jehan J. El-Jawhari, P Stocks, D Dastros-Pitel, Z Liu, Bdm Tom, Dennis Lendrem, Wayne Tsuji, F Stirling, J Worthington, Deborah P M Symmons, Matthew A. Sleeman, D Padhji, Fowzia Ibrahim, Smm Verstappen, P Budde, Ehrenstein, Marc C. Levesque, R Harry, B Allen, T Sabin, Michael Binks, Sally Hollis, Gerry Parker, S Lipsky, Georgina Thorborn, M Jenkins, A Hughes-Morley, Costantino Pitzalis, N Joseph, H Edwards, Jamie C. Sergeant, Paul Emery, H Ali, JA Butler, Liliane Fossati-Jimack, S Wright, Fiona Clarke, W Wu, Amy E. Anderson, Sharmila Rana, F Humby, F Hong, Myles Lewis, A Haynes, Katriona Goldmann, S Martins, CT Mela, S Hasan, David Scott, L Rowell, David Watson, Neil Gozzard, Karim Raza, Simon Read, M Hodge, Carl S. Goodyear, Farewell, George Davey Smith, Michele Bombardieri, Iain B. McInnes, C Larminie, G Simpson, N Ward, K Hicks, R Rao, Z Jia, FB Capdevila, A Long
Publikováno v:
RA-MAP Consortium, Tom, B & Symmons, D 2018, ' Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data ', RMD Open, vol. 4, no. 2, pp. e000721 . https://doi.org/10.1136/rmdopen-2018-000721
RMD Open
RMD Open
ObjectivesTo identify predictors of remission and disease activity patterns in patients with rheumatoid arthritis (RA) using individual participant data (IPD) from clinical trials.MethodsPhase II and III clinical trials completed between 2002 and 201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b48a096d68180fc5745f1e771c2710f
https://doi.org/10.1136/rmdopen-2018-000721
https://doi.org/10.1136/rmdopen-2018-000721
Autor:
Roger Palframan, Daniel John Lightwood, Tim Bourne, Monique Zehentleitner, Bryan Smith, Neil Gozzard, Kaushik Sarkar, Stevan Shaw, Sabrina Lamour, Alison Turner, Markus Tservistas
Publikováno v:
Allergy and immunology.
Background: IL-13 is a key cytokine in the pathogenesis of allergic asthma. Efficacy with systemically administered anti-IL-13 mAb therapies is mixed; inhaled mAbs may provide targeted treatment for patients. Aim: To investigate the efficacy of CDP77
Autor:
Hugo H. Knobel, Koos Zwinderman, Anton Vink, Laurie Pahus, Elisabeth H. Bel, Wim van Aalderenm, Massimo Caruso, Marianne A. van de Pol, Lorraine Hewitt, David Balgoma, Jilaiha Gent, Paul Skipp, Sally Meah, Grazyna Bochenek, Martina Gahlemann, Xugang Hu, Graham Roberts, Stephen J. Fowler, Aleksandra Draper, Jon R Konradsen, Craig E. Wheelock, Philips Monk, Roelinde Middelveld, Päivi Söderman, Stelios Pavlidis, João P. Carvalho da Purfição Rocha, Caroline Smith, Alan J. Knox, Doroteya Staykova, Ildiko Horvath, Nadia Mores, Christophe von Garnier, Frans Wald, Uruj Hoda, Giuseppe Santini, Anne Petrén, Thomas Sandström, Alexander Mazein, Tamara Dekker, Ana R. Sousa, Andrea Maiser, Zsoka Weiszhart, Wolfgang Seibold, Susanna Palkonnen, Johan Kolmert, Cristina Gómez, Marco Sentoninco, Nancy Peffer, Anna James, Ingrid Delin, Montse Miralpeix, Antonios Aliprantis, Annemiek Dijkhuis, Amanda Roberts, Clare S. Murray, Lara Ravanetti, Yike Guo, Jenny Versnel, Richard Hu, Saeeda Lone-Satif, Jonathan Ward, Martine Robberechts, René Lutter, Linn Krueger, Antonio Pacino, Arnaldo D'Amico, Jans Hohlfeld, Scott Wagers, Neil Fitch, Pippa Powel, Matthew J. Loza, Karin Strandberg, Damijan Erzen, H. Ahmed, Per Bakke, Neil Gozzard, David Gibeon, Arianne Wagerner, Kerry Gove, Siân Williams, Ann Berglind, Rosalia Emma, Bob Thornton, Val Hudson, Elizabeth Yeyashingham, John Haughney, Ann-Sofie Lantz, Kjell Alving, Bart N. Lambrecht, Marek Sanak, Lilla Tamasi, Nadja Hawwa Vissing, Katja Nething, Barbro Dahlén, Jacek Musiał, Pim de Boer, Marcus O.D. Sjödin, Sarah Masefield, Marleen van Geest, Maciej Kupczyk, Peter H. Howarth, Alix Berton, Peter J. Sterk, David Myles, Peter Nilsson, Emma Ray, Ian M. Adcock, Pascal Chanez, Christos Rossios, Paolo Montuschi, Inge De Lepeleire, Armin Braun, Juliette Kamphuis, Davide Campagna, Salvatore Valente, Kees van Drunen, Urs Frey, Philipp Badorek, Ralf Sigmund, Malayka Rahman-Amin, Maria Mikus, James P.R. Schofield, Simone Hashimoto, Marton Szentkereszty, Gabriella Galffy, Lisa Marouzet, Barbara Smids, L. Larsson, Louise Fleming, Corinna Schoelch, Leanne Metcalf, Ashley Woosdcock, Anthony D. Postle, Maxim Kots, Sven-Erik Dahlén, J. M. Edwards, J.C. Smith, Gunilla Hedlin, Breda Flood, Veit J. Erpenbeck, Wen Yu, Susan J. Wilson, Jeanette Bigler, Jorge De Alba, Leon Carayannopoulos, Kristiane Wetzel, Klaus Fichtner, Paul Brinkman, Cecile T.J. Holweg, David Supple, Romanas Chaleckis, Coen Wiegman, Anthony Rowe, Hans Bisgaard, Annelie F. Behndig, Joost Brandsma, Richard G. Knowles, Jorge Beleta, Scott Kuo, Katherine M. Smith, Sandy Pink, Pieter-Paul Hekking, An Bautmans, Ben Nicholas, Kathrin Riemann, Michael Rutgers, Leanne Reynolds, Adesimbo Sogbesan, Dominic Burg, Aruna T. Bansal, Ulf Nihlen, Dyson Kerry, Ioannis Pandis, Julie Corfield, Björn Nordlund, Shama Naz, Wilhelm Zetterquist, Diane Lefaudeux, Xian Yang, Clair Barber, Kirsty E. Russell, Andrew Menzies-Gow, Dominic E. Shaw, Patrick Dennison, Elisabeth Henriksson, John G. Matthews, Tim Higgenbottam, Ratko Djukanovic, Charles Auffray, Kai Sun, Amphun Chaiboonchoe, Jonathan Thorsen, Nikos Lazarinis, Samantha Walker, John-Olof Thörngren, Frédéric Baribaud, Florian Singer, Klaus Bøonnelykke, John H. Riley, Magnus Ericsson, Sile Hu, Jørgen Vestbo, Bertrand De Meulder, Kamran Tariq, Maria Gerhardsson de Verdier, Stacey N. Reinke, Navin Rao, Trevor Garret, Norbert Krug, Michael Boedigheimer, Chris Compton, Cornelia Faulenbach, Hector Gallart, Matthias Klüglich, Caroline Mathon, Giorgio Pennazza, Kian Fan Chung, Thomas Geiser, Jörgen Östling, Courtney Coleman, Erika Kennington, Nora Adriaens, Jane Martin
Publikováno v:
Journal of allergy and clinical immunology, 139(6), 1797-1807. Mosby Inc.
Lefaudeux, D, De Meulder, B, Loza, M J, Peffer, N, Rowe, A, Baribaud, F, Bansal, A T, Lutter, R, Sousa, A R, Corfield, J, Pandis, I, Bakke, P S, Caruso, M, Chanez, P, Dahlén, S-E, Fleming, L J, Fowler, S, Horvath, I, Krug, N, Montuschi, P, Sanak, M, Sandstrom, T, Shaw, D E, Singer, F, Sterk, P J, Roberts, G, Adcock, I M, Djukanovic, R, Auffray, C, Chung, K F & U-BIOPRED Study Group 2017, ' U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics ', Journal of Allergy and Clinical Immunology, vol. 139, no. 6, pp. 1797 . https://doi.org/10.1016/j.jaci.2016.08.048, https://doi.org/10.1016/j.jaci.2016.08.048
Lefaudeux, D, De Meulder, B, Loza, M J, Peffer, N, Rowe, A, Baribaud, F, Bansal, A T, Lutter, R, Sousa, A R, Corfield, J, Pandis, I, Bakke, P S, Caruso, M, Chanez, P, Dahlén, S-E, Fleming, L J, Fowler, S, Horvath, I, Krug, N, Montuschi, P, Sanak, M, Sandstrom, T, Shaw, D E, Singer, F, Sterk, P J, Roberts, G, Adcock, I M, Djukanovic, R, Auffray, C, Chung, K F & U-BIOPRED Study Group 2017, ' U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics ', Journal of Allergy and Clinical Immunology, vol. 139, no. 6, pp. 1797 . https://doi.org/10.1016/j.jaci.2016.08.048, https://doi.org/10.1016/j.jaci.2016.08.048
BACKGROUND: Asthma is a heterogeneous disease in which there is a differential response to asthma treatments. This heterogeneity needs to be evaluated so that a personalised management approach can be provided.OBJECTIVES: We stratified patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb05fd5f8f224a60a64676698b62ac
https://ruj.uj.edu.pl/xmlui/handle/item/138911
https://ruj.uj.edu.pl/xmlui/handle/item/138911
Autor:
Daniel, Lightwood, Victoria, O'Dowd, Bruce, Carrington, Vaclav, Veverka, Mark D, Carr, Markus, Tservistas, Alistair J, Henry, Bryan, Smith, Kerry, Tyson, Sabrina, Lamour, Marguerite, Bracher, Kaushik, Sarkar, Alison, Turner, Alastair D, Lawson, Tim, Bourne, Neil, Gozzard, Roger, Palframan
Publikováno v:
Journal of Molecular Biology. 425:577-593
We describe the discovery, engineering and characterisation of a highly potent anti-human interleukin (IL)-13 Fab fragment designed for administration by inhalation. The lead candidate molecule was generated via a novel antibody discovery process, an
Publikováno v:
British Journal of Pharmacology. 165:1978-1991
BACKGROUND AND PURPOSE TNF-α is an inflammatory cytokine implicated in the pathogenesis of asthma and it causes airway inflammation, bronchoconstriction and airway hyperresponsiveness to a number of spasmogens following inhalation.