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pro vyhledávání: '"Neil E. Torbett"'
Autor:
William A. Weiss, Neil E. Torbett, Zachary A. Knight, Mark M. Moasser, Antonio Luna-Moran, Kevan M. Shokat, David Stokoe, Andrew R. Houk
Publikováno v:
Biochemical Journal. 415:97-110
The PI3K (phosphoinositide 3-kinase) pathway regulates cell proliferation, survival and migration and is consequently of great interest for targeted cancer therapy. Using a panel of small-molecule PI3K isoform-selective inhibitors in a diverse set of
Publikováno v:
Journal of Biological Chemistry. 278:32344-32351
Protein kinase N 1 (PKN1), which in part resembles yeast protein kinase C, has been shown to be under the control of Rho GTPases and 3-phosphoinositide-dependent kinase 1 (PDK1). We show here that green fluorescent protein-tagged PKN1 has the ability