Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Neil E. Alexis"'
Autor:
Katarina M. DiLillo, Katy C. Norman, Christine M. Freeman, Stephanie A. Christenson, Neil E. Alexis, Wayne H. Anderson, Igor Z. Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, Eugene R. Bleecker, Richard C. Boucher, David J. Couper, Gerard J. Criner, Claire M. Doerschuk, J. Michael Wells, MeiLan K. Han, Eric A. Hoffman, Nadia N. Hansel, Annette T. Hastie, Robert J. Kaner, Jerry A. Krishnan, Wassim W. Labaki, Fernando J. Martinez, Deborah A. Meyers, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, Prescott G. Woodruff, Christopher B. Cooper, Russell P. Bowler, Jeffrey L. Curtis, Kelly B. Arnold, SPIROMICS investigators
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease-m
Externí odkaz:
https://doaj.org/article/44f990fcab4543089c5321fad16440df
Autor:
Yinbiao Wang, Rui Zhang, Fuyun Yang, Lin Yang, Qingmei Li, Junqing Guo, Xiao Liu, Jie Song, Guofu Zhang, Juan Li, Zhen An, Neil E. Alexis, Ilona Jaspers, Weidong Wu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 259, Iss , Pp 115069- (2023)
Exposure to particulate matter (PM) has been associated with increased hospital admissions for influenza. Airway epithelial cells are a primary target for inhaled environmental insults including fine PM (PM2.5) and influenza viruses. The potentiation
Externí odkaz:
https://doaj.org/article/ebec6e227fbc457ab83427ceceab119d
Autor:
Vickram Tejwani, Han Woo, Chen Liu, Anna K. Tillery, Amanda J. Gassett, Richard E. Kanner, Eric A. Hoffman, Fernando J. Martinez, Prescott G. Woodruff, R. Graham Barr, Ashraf Fawzy, Kirsten Koehler, Jeffrey L. Curtis, Christine M. Freeman, Christopher B. Cooper, Alejandro P. Comellas, Cheryl Pirozzi, Robert Paine, Donald Tashkin, Jerry A. Krishnan, Coralynn Sack, Nirupama Putcha, Laura M. Paulin, Marina Zusman, Joel D. Kaufman, Neil E. Alexis, Nadia N. Hansel
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black carbon (BC). However, wh
Externí odkaz:
https://doaj.org/article/560d7cf59df54945adb8be143473ac12
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15348 (2023)
Proteases such as neutrophil elastase cleave and activate the epithelial sodium channel (ENaC), causing airway dehydration. Our current study explores the impact of increased protease levels in vapers’ airways on ENaC activity and airway dehydratio
Externí odkaz:
https://doaj.org/article/fef5dbdae49f48df86a0a1608e527e85
Autor:
Elise Hickman, Timothy Smyth, Catalina Cobos-Uribe, Robert Immormino, Meghan E. Rebuli, Timothy Moran, Neil E. Alexis, Ilona Jaspers
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
Respiratory macrophage subpopulations exhibit unique phenotypes depending on their location within the respiratory tract, posing a challenge to in vitro macrophage model systems. Soluble mediator secretion, surface marker expression, gene signatures,
Externí odkaz:
https://doaj.org/article/1ea51be14ae44e60aeceb5f37c2b877d
Autor:
Hao Chen, Haiyan Tong, Wan Shen, Tracey S. Montilla, Martin W. Case, Martha A. Almond, Heather B. Wells, Neil E. Alexis, David B. Peden, Ana G. Rappold, David Diaz-Sanchez, Robert B. Devlin, Philip A. Bromberg, James M. Samet
Publikováno v:
Environment International, Vol 167, Iss , Pp 107407- (2022)
Background: Over one-third of the U.S. population is exposed to unsafe levels of ozone (O3). Dietary supplementation with fish oil (FO) or olive oil (OO) has shown protection against other air pollutants. This study evaluates potential cardiopulmonar
Externí odkaz:
https://doaj.org/article/a10c699d506145f597b00aa66657959b
Autor:
Kristopher Opron, Lesa A. Begley, John R. Erb-Downward, Christine Freeman, Siddharth Madapoosi, Neil E. Alexis, Igor Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Stephanie A. Christenson, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Claire M. Doerschuk, Mark T. Dransfield, MeiLan K. Han, Nadia N. Hansel, Annette T. Hastie, Eric A. Hoffman, Robert J. Kaner, Jerry Krishnan, Wanda K. O’Neal, Victor E. Ortega, Robert Paine, Stephen P. Peters, J. Michael Wells, Prescott G. Woodruff, Fernando J. Martinez, Jeffrey L. Curtis, Gary B. Huffnagle, Yvonne J. Huang
Publikováno v:
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that ref
Externí odkaz:
https://doaj.org/article/10a254afe79640d29b0d02561b498bb0
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Tobacco smoke exposure impairs the lung’s innate immune response, leading to an increased risk of chronic infections. SPLUNC1 is a secreted, multifunctional innate defense protein that has antimicrobial activity against Gram neg
Externí odkaz:
https://doaj.org/article/76fe6ab5c61447c0a123f8ccc6707410
Autor:
Tongde Wu, Julianne Huang, Patrick J. Moore, Michael S. Little, William G. Walton, Robert C. Fellner, Neil E. Alexis, Y. Peter Di, Matthew R. Redinbo, Stephen L. Tilley, Robert Tarran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the
Externí odkaz:
https://doaj.org/article/c13d74cd6193402c97012e807c2d9c19
Autor:
Spyridon Fortis, Pedro M. Quibrera, Alejandro P. Comellas, Surya P. Bhatt, Donald P. Tashkin, Eric A. Hoffman, Gerard J. Criner, MeiLan K. Han, R. Graham Barr, Mehrdad Arjomandi, Mark B. Dransfield, Stephen P. Peters, Brett A. Dolezal, Victor Kim, Nirupama Putcha, Stephen I. Rennard, Robert Paine, Richard E. Kanner, Jeffrey L. Curtis, Russell P. Bowler, Fernando J. Martinez, Nadia N. Hansel, Jerry A. Krishnan, Prescott G. Woodruff, Igor Z. Barjaktarevic, David Couper, Wayne H. Anderson, Christopher B. Cooper, Neil E. Alexis, Igor Barjaktarevic, Patricia Basta, Lori A. Bateman, Eugene R. Bleecker, Richard C. Boucher, Stephanie A. Christenson, David J. Couper, Ronald G. Crystal, Claire M. Doerschuk, Mark T. Dransfield, Brad Drummond, Christine M. Freeman, Craig Galban, Annette T. Hastie, Yvonne Huang, Robert J. Kaner, Eric C. Kleerup, Lisa M. LaVange, Stephen C. Lazarus, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Laura Paulin, Cheryl Pirozzi, Elizabeth C. Oelsner, Wanda K. O’Neal, Victor E. Ortega, Sanjeev Raman, J. Michael Wells, Robert A. Wise
Publikováno v:
Chest. 163:502-514
Bronchodilator responsiveness (BDR) in obstructive lung disease varies over time and may be associated with distinct clinical features.Is consistent BDR over time (always present) differentially associated with obstructive lung disease features relat