Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Neil Dear"'
Autor:
Nicholas Parkinson, Rachel E Hardisty-Hughes, Hilda Tateossian, Hsun-Tien Tsai, Debra Brooker, Sue Morse, Zuzanna Lalane, Francesca MacKenzie, Martin Fray, Pete Glenister, Anne-Marie Woodward, Sian Polley, Ivana Barbaric, Neil Dear, Tertius A Hough, A Jackie Hunter, Michael T Cheeseman, Steve D M Brown
Publikováno v:
PLoS Genetics, Vol 2, Iss 10, p e149 (2006)
Otitis media (OM), inflammation of the middle ear, remains the most common cause of hearing impairment in children. It is also the most common cause of surgery in children in the developed world. There is evidence from studies of the human population
Externí odkaz:
https://doaj.org/article/4e04b3f64b7f43c8b014fa9eef6c1a5c
Autor:
Terence H. Rabbitts, Kenneth MacLennan, T. Neil Dear, Juan C. Cigudosa, Leah Khazin, Nicola J. Geisler, Hanif Ali, Tim Brend, Tomoyuki Tanaka, Jennifer S. Chambers
The discovery of chromosomal translocations in leukemia/lymphoma and sarcomas presaged a widespread discovery in epithelial tumors. With the advent of new-generation whole-genome sequencing, many consistent chromosomal abnormalities have been describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfce18cb537779797ebbbd01059bcd6c
https://doi.org/10.1158/0008-5472.c.6505839
https://doi.org/10.1158/0008-5472.c.6505839
Publikováno v:
Cell Reports, Vol 4, Iss 4, Pp 738-750 (2013)
Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disru
Externí odkaz:
https://doaj.org/article/0776b5a27039463f9b846c825f5e0864
Autor:
Sheila E. Francis, Adrienn Angyal, Robert C. Bauer, S. Kim Suvarna, T. Neil Dear, Jessica Johnston, Endre Kiss-Toth, Stephen E. Hamby, Zoltan Hegedus, Alison H. Goodall, Martin R Turner, Kajus Baidžajevas, Heather L. Wilson, Carol C. Shoulders, Daniel J. Rader
Publikováno v:
Science Advances
Trib1 controls atherosclerotic plaque macrophage function by up-regulating OLR1, promoting foam cell formation and atherosclerosis.
Macrophages drive atherosclerotic plaque progression and rupture; hence, attenuating their atherosclerosis-induci
Macrophages drive atherosclerotic plaque progression and rupture; hence, attenuating their atherosclerosis-induci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41411a0d6d096ec377014d0abccaf7f2
Autor:
Hannah K. Brown, Kimberley J. Reeves, Terence Neil Dear, Penelope D. Ottewell, Colby L. Eaton, Ning Wang, Freyja E. Docherty, Ingunn Holen, A. Fowles, Peter I. Croucher
Publikováno v:
Journal of Bone and Mineral Research. 29:2688-2696
It has been suggested that metastasis-initiating cells gain a foothold in bone by homing to a metastastatic microenvironment (or "niche"). Whereas the precise nature of this niche remains to be established, it is likely to contain bone cell populatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::433b7579e1130a8bdccbf17bcc77fe72
https://doi.org/10.1002/jbmr.2300
https://doi.org/10.1002/jbmr.2300
Autor:
Jan Bilton, Hyejeong R. Kim, Zhaojun Fu, Baptiste Rode, Jing Li, Paul Ajuh, Helen Imrie, Sarka Tumova, Nadira Yuldasheva, Katsuhiko Muraki, Richard S. Young, K. Raj Prasad, David J. Beech, Lesley A. Wilson, T. Neil Dear, Lynn McKeown, Justin F. X. Ainscough, Deborah Angela Louise Carter, Bing Hou, Paul C. Evans, Melanie J. Ludlow, Alicia Sedo, Richard M Cubbon, Adam J. Hyman, Marc A. Bailey, Yasser Majeed, Alexander F. Bruns, Mark T. Kearney
Publikováno v:
Nature. 515:279-282
The mechanisms by which physical forces regulate endothelial cells to determine the complexities of vascular structure and function are enigmatic. Studies of sensory neurons have suggested Piezo proteins as subunits of Ca(2+)-permeable non-selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c3957846c1da97f42a558152df57152
https://doi.org/10.1038/nature13701
https://doi.org/10.1038/nature13701
Autor:
Terence H. Rabbitts, Nicola J. Geisler, Hanif Ali, Juan C. Cigudosa, Kenneth A. MacLennan, Jennifer S. Chambers, Leah Khazin, T. Neil Dear, Tomoyuki Tanaka, Tim Brend
The discovery of chromosomal translocations in leukemia/lymphoma and sarcomas presaged a widespread discovery in epithelial tumors. With the advent of new-generation whole-genome sequencing, many consistent chromosomal abnormalities have been describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f97182788042c284b40b6e6167465b
https://ora.ox.ac.uk/objects/uuid:3e308e2b-d135-480b-8122-3d131d8cdc40
https://ora.ox.ac.uk/objects/uuid:3e308e2b-d135-480b-8122-3d131d8cdc40
Autor:
Dorota Szumska, Debbie Williams, Michael Cheeseman, Violetta Steeples, Narcis Fernandez-Fuentes, Sara Wells, T. Neil Dear, Zuzanne Lalanne, John M. Land, Christopher Towlson, Ivana Barbaric, Monica Neilan, Julian L. Griffin, D. P. Norris, Iain P. Hargreaves, Craig A. Lygate, Louise Docherty, Tertius Hough, Hugh Watkins, Vincenzo C. Leo, Stuart Townsend, Shoumo Bhattacharya, Paul Denny, Houman Ashrafian, Sarah Glyn-Jones
Publikováno v:
Ashrafian, H, Docherty, L, Leo, V, Towlson, C, Neilan, M, Steeples, V, Lygate, C A, Hough, T, Townsend, S, Williams, D, Wells, S, Norris, D, Glyn-Jones, S, Land, J, Barbaric, I, Lalanne, Z, Denny, P, Szumska, D, Bhattacharya, S, Griffin, J L, Hargreaves, I, Fernandez-Fuentes, N, Cheeseman, M, Watkins, H & Dear, T N 2010, ' A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy ', PLoS Genetics, vol. 6, no. 6, ARTN e1001000 . https://doi.org/10.1371/journal.pgen.1001000
PLoS Genetics, Vol 6, Iss 6, p e1001000 (2010)
PLoS Genetics
PLoS Genetics, Vol 6, Iss 6, p e1001000 (2010)
PLoS Genetics
Mutations in a number of genes have been linked to inherited dilated cardiomyopathy (DCM). However, such mutations account for only a small proportion of the clinical cases emphasising the need for alternative discovery approaches to uncovering novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ea473c430b5e9b0ff1b009a59f8c2d
https://doi.org/10.1371/journal.pgen.1001000
https://doi.org/10.1371/journal.pgen.1001000
Autor:
Jochen C. Meier, Terence Neil Dear, Richard Delorme, Pascal Legendre, Jing Bai, Coralie Fassier, Gudrun Nygren, Elsa Delaby, Marion Leboyer, Marion Pilorge, S. De Gois, Jamilé Hazan, H. Le Corronc, H. Cheval, A. Potey, Satoru Otani, Vincent Guinchat, Brigitte Assouline, Maya Topf, Sophie Gautron, Catalina Betancur, Bruno Giros, Françoise Devillard, Christopher Gillberg, Victoria M. James, Maria Råstam, Robert J. Harvey
Publikováno v:
Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2016, 21 (7), pp.936-945 ⟨10.1038/mp.2015.139⟩
Molecular Psychiatry, 2016, 21 (7), pp.936-945 ⟨10.1038/mp.2015.139⟩
Molecular Psychiatry, Nature Publishing Group, 2016, 21 (7), pp.936-945 ⟨10.1038/mp.2015.139⟩
Molecular Psychiatry, 2016, 21 (7), pp.936-945 ⟨10.1038/mp.2015.139⟩
International audience; Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized by marked genetic heterogeneity. Recent studies of rare structural and sequence variants have identified hundreds of loci involved in ASD, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d24e751cdb6d7e3469339518d2e7e13
https://www.hal.inserm.fr/inserm-01211157
https://www.hal.inserm.fr/inserm-01211157
Publikováno v:
Hum Mol Genet
Mitochondria are dynamic organelles that divide and fuse by remodeling an outer and inner membrane in response to developmental, physiological and stress stimuli. These events are coordinated by conserved dynamin-related GTPases. The dynamics of mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb6b7f1fbd079c95d4aeb34d1a91b31
https://hdl.handle.net/21.11116/0000-000B-83A4-7
https://hdl.handle.net/21.11116/0000-000B-83A4-7