Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Neil D. Detweiler"'
Autor:
Selina M. Garcia, Tracy R. Yellowhair, Neil D. Detweiler, Rosstin Ahmadian, Lindsay M. Herbert, Laura V. Gonzalez Bosc, Thomas C. Resta, Nikki L. Jernigan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in
Externí odkaz:
https://doaj.org/article/5b0acd1eae6c415191754f383d469cd3
Autor:
Nikki L Jernigan, Jay S Naik, Laura Weise-Cross, Neil D Detweiler, Lindsay M Herbert, Tracylyn R Yellowhair, Thomas C Resta
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180455 (2017)
Pulmonary arterial hypertension is associated with a decreased antioxidant capacity. However, neither the contribution of reactive oxygen species to pulmonary vasoconstrictor sensitivity, nor the therapeutic efficacy of antioxidant strategies in this
Externí odkaz:
https://doaj.org/article/1a2e75e75e8248a18fdc9866cb7f85e6
Autor:
Kenneth G. Vigil, Simin Yan, Benjimen R. Walker, Joshua R. Sheak, Lindsay M. Herbert, Neil D. Detweiler, Nikki L. Jernigan, Selina Garcia, Thomas C. Resta
Publikováno v:
J Appl Physiol (1985)
Acid-sensing ion channels (ASICs) are voltage-insensitive cation channels that contribute to cellular excitability. We previously reported that ASIC1 in pulmonary artery smooth muscle cells (PASMC) contribute to pulmonary vasoreactivity and vascular
Autor:
Kenneth G. Vigil, Nikki L. Jernigan, Lindsay M. Herbert, Neil D. Detweiler, Thomas C. Resta, Michael C. Bennett, Benjimen R. Walker, Simin Yan
Publikováno v:
The FASEB Journal. 32
Autor:
Thomas C. Resta, Eric R. Prossnitz, Nikki L. Jernigan, Helen J. Hathaway, Laura Weise Cross, Neil D. Detweiler, Jessica B. Snow, Logan Wolfel
Publikováno v:
The FASEB Journal. 32
Autor:
Lindsay M. Herbert, Jay S. Naik, Nikki L. Jernigan, Neil D. Detweiler, Laura Weise-Cross, Tracylyn R. Yellowhair, Thomas C. Resta
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180455 (2017)
PLoS ONE
PLoS ONE
Pulmonary arterial hypertension is associated with a decreased antioxidant capacity. However, neither the contribution of reactive oxygen species to pulmonary vasoconstrictor sensitivity, nor the therapeutic efficacy of antioxidant strategies in this
Autor:
Nancy J. Rusch, Li Song, Neil D. Detweiler, Sujay V. Kharade, Rachel Versluis, Richard C. Kurten, Samantha J. McClenahan, Sung W. Rhee
A loss of K+ efflux in pulmonary arterial smooth muscle cells (PASMCs) contributes to abnormal vasoconstriction and PASMC proliferation during pulmonary hypertension (PH). Activation of high-conductance Ca2+-activated (BK) channels represents a thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435af92178d9a18e1a805e5b15913ebb
https://europepmc.org/articles/PMC5210062/
https://europepmc.org/articles/PMC5210062/
Autor:
Dinesh K. Hirenallur-S., Jeaninne T. Leming, Neil D. Detweiler, John B. Gordon, Steven T. Haworth, Nancy J. Rusch
Publikováno v:
Pulmonary Circulation
The development of pulmonary arterial hypertension (PAH) in pediatric patients has been linked to the production of the arachidonic acid metabolite, thromboxane A(2) (TxA(2)). The present study evaluated the therapeutic effect of furegrelate sodium,
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192724 (2018)
PLoS ONE
PLoS ONE
Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown. We tested the hypothes
Publikováno v:
The FASEB Journal. 28
We reported an upregulation of an oxygen-insensitive splice variant of the high-conductance Ca2+-activated K+ (BK) channel in pulmonary arteries (PA) from rats with chronic hypoxia (CH)-induced pul...