Výsledky vyhledávání - "Neil C. Robson"

Akademický článek

A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen.

Autor: Rona Y Zhao, Nicole A Mifsud, Kun Xiao, Kok-Fei Chan, Sara Oveissi, Heather M Jackson, Nektaria Dimopoulos, Philippe Guillaume, Ashley J Knights, Tamara Lowen, Neil C Robson, Sarah E Russell, Emmanuel Scotet, Ian D Davis, Eugene Maraskovsky, Jonathan Cebon, Immanuel F Luescher, Weisan Chen

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44707 (2012)

NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8(+) T cell epitope, NY-ESO-1(88-96) (LEFYLAMPF) and

Externí odkaz: https://doaj.org/article/146e55fe334e4f2989434de0126990e4

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Presentation of tumour antigens by dendritic cells and challenges faced

Autor: Max Schnurr, Sabine Hoves, Eugene Maraskovsky, Neil C Robson

Publikováno v: Current Opinion in Immunology. 22:137-144

The use of dendritic cells (DCs) for the generation of anti-tumour immunity has been the focus of a vast array of scientific and clinical studies. The ability of DCs to present protein tumour antigens (T-Ags) to CD4(+) and CD8(+) T cells is pivotal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce5c9b8aa43061e0c27705f0090b7ec
https://doi.org/10.1016/j.coi.2010.01.002

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ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II

Autor: Neil C Robson, Eugene Maraskovsky, Max Schnurr, Hal Braley, Stefan Endres, Amanda Shin, Denise Airey, Jonathan Cebon, Martin Orban

Publikováno v: The Journal of Immunology. 182:1253-1259

Cancer vaccines aim to induce antitumor CTL responses, which require cross-presentation of tumor Ag to CTLs by dendritic cells (DCs). Adjuvants that facilitate cross-presentation of vaccine Ag are therefore key for inducing antitumor immunity. We pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c532714254f9923063ea2e09b72672
https://doi.org/10.4049/jimmunol.182.3.1253

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Directed evolution for improved secretion of cancer–testis antigen NY-ESO-1 from yeast

Autor: Eugene Maraskovsky, Gerd Ritter, Shanshan W. Howland, Lloyd Old, Neil C Robson, Andrea Piatesi, K. Dane Wittrup, Christoph Renner, Jonathan Cebon, James A. Rakestraw

Publikováno v: Protein Expression and Purification. 48:232-242

NY-ESO-1 is a highly immunogenic tumor antigen and a promising vaccine candidate in cancer immunotherapy. Access to purified protein both for vaccine formulations and for monitoring antigen-specific immune responses is vital to vaccine development. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34f44d307cf2ffd96e09bd90094bd94
https://doi.org/10.1016/j.pep.2006.01.026

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The role of antigen-presenting cells and interleukin-12 in the priming of antigen-specific CD4+ T cells by immune stimulating complexes

Autor: Neil C Robson, Anne M. Donachie, Helen Beacock-Sharp, Allan McI. Mowat

Publikováno v: Immunology. 110:95-104

Immune stimulating complexes (ISCOMs) containing the saponin adjuvant Quil A are vaccine adjuvants that promote a wide range of immune responses in vivo, including delayed-type hypersensitivity (DTH) and the secretion of both T helper 1 (Th1) and Th2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e580216b6144fae34c57b353412e9fd2
https://doi.org/10.1046/j.1365-2567.2003.01705.x

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Dendritic cell maturation enhances CD8+ T-cell responses to exogenous antigen via a proteasome-independent mechanism of major histocompatibility complex class I loading

Autor: Anne M. Donachie, Helen Beacock-Sharp, Allan McI. Mowat, Neil C Robson

Publikováno v: Immunology. 109:374-383

Immune stimulating complexes (ISCOMS) containing the saponin adjuvant Quil A are vaccine adjuvants that induce a wide range of immune responses in vivo, including strong class I major histocompatibility complex (MHC) -restricted cytotoxic T-lymphocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ef19e8339a9c8bdc124196da86ef2d
https://doi.org/10.1046/j.1365-2567.2003.01664.x

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A Novel HLA-B18 Restricted CD8+ T Cell Epitope Is Efficiently Cross-Presented by Dendritic Cells from Soluble Tumor Antigen

Autor: Tamara Lowen, Nicole A. Mifsud, Kun Xiao, Sara Oveissi, Jonathan Cebon, Eugene Maraskovsky, Heather Jackson, Kok-fei Chan, Immanuel F. Luescher, Ian D. Davis, Philippe Guillaume, Ashley Knights, Sarah E Russell, Rona Y Zhao, Weisan Chen, Nektaria Dimopoulos, Neil C Robson, Emmanuel Scotet

Publikováno v: Plos One, vol. 7, no. 9, pp. e44707
PLoS ONE, Vol 7, Iss 9, p e44707 (2012)
PLoS ONE

NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8+T cell epitope, NY-ESO-188–96 (LEFYLAMPF) and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74de3de0976e6474a4ee41e9d1647ab
https://serval.unil.ch/resource/serval:BIB_7E77F0F308BA.P001/REF.pdf

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