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pro vyhledávání: '"Neil C. Chada"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Cells in vivo live in a complex microenvironment composed of the extracellular matrix (ECM) and other cells. Growing evidence suggests that the mechanical interaction between the cells and their microenvironment is of critical importance to their beh
Externí odkaz:
https://doaj.org/article/8d3769f8991e4784b18555f6b29d0639
Publikováno v:
Biomolecules, Vol 8, Iss 3, p 48 (2018)
Retinoic acid (RA) is a bioactive lipid that has been shown to promote neural stem cell differentiation. However, the highly hydrophobic molecule needs to first solubilize and translocate across the cell membrane in order to exert a biological respon
Externí odkaz:
https://doaj.org/article/6ccf8fdfaca249ddbef06eea52e42291
Autor:
Matthew R. Zanotelli, Jian Zhang, Ismael Ortiz, Wenjun Wang, Neil C. Chada, Cynthia A. Reinhart-King
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(18)
Altered tissue mechanics and metabolism have gained significant attention as drivers of tumorigenesis, and mechanoresponsive metabolism has been implicated in migration and metastasis. However, heterogeneity in cell populations makes it difficult to
Publikováno v:
Biophysical Reviews and Letters. 15:51-82
The tumor microenvironment plays a critical role in tumorigenesis and metastasis. As tightly controlled extracellular matrix homeostasis is lost during tumor progression, a dysregulated extracellular matrix can significantly alter cellular phenotype