Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Neil Benson"'
Autor:
Andrzej M. Kierzek, Timothy P. Hickling, Isabel Figueroa, J. Cory Kalvass, Marjoleen Nijsen, Krithika Mohan, Geertruida M. Veldman, Akihiro Yamada, Hiroyuki Sayama, Sachiko Yokoo, Abhishek Gulati, Renu S. Dhanikula, Jochem Gokemeijer, Tarek A. Leil, Craig J. Thalhauser, Mario Giorgi, Maciej J. Swat, Vijayalakshmi Chelliah, Ben G. Small, Neil Benson, Michael Walker, Kapil Gadkar, Valerie Quarmby, Rong Deng, Andrea Ferrante, Gemma L. Dickinson, Jan‐Stefan Van Der Walt, Lian Zhou, Xiaoying Chen, Hannah M. Jones, Jatin Narula, Sophie Tourdot, Thierry Lavé, Benjamin Ribba, Piet H. van derGraaf
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 773-776 (2019)
Externí odkaz:
https://doaj.org/article/368f598c595b469b8b9deb6681ea6d5a
Autor:
Neil Benson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 3, Pp 135-137 (2019)
Externí odkaz:
https://doaj.org/article/369d8677be30447d8ff945330ca32845
Autor:
Andrea Ferrante, Lian Zhou, Marjoleen Nijsen, J. Cory Kalvass, Renu S Dhanikula, Gemma L. Dickinson, Piet H. van der Graaf, Isabel Figueroa, Kapil Gadkar, Andrzej M. Kierzek, Neil Benson, Akihiro Yamada, Michael Walker, Benjamin Ribba, Thierry Lavé, Sophie Tourdot, Jan-Stefan van der Walt, Abhishek Gulati, Hiroyuki Sayama, Jatin Narula, Valerie Quarmby, Vijayalakshmi Chelliah, Ben G Small, Xiaoying Chen, Rong Deng, Sachiko Yokoo, Maciej J. Swat, Craig J. Thalhauser, Krithika Mohan, Hannah M. Jones, Geertruida M. Veldman, Timothy P. Hickling, Jochem Gokemeijer, Mario Giorgi, Tarek A. Leil
Publikováno v:
CPT Pharmacometrics Syst Pharmacol
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 773-776 (2019)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 773-776 (2019)
CPT: Pharmacometrics & Systems Pharmacology
Immunogenicity is a major challenge in drug development and patient care. Currently, most efforts are dedicated to the elimination of the unwanted immune responses through T‐cell epitope prediction and protein engineering. However, because it is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1101d65d4d512bb2b5d4501d81dc7645
https://eprints.whiterose.ac.uk/153749/1/Kierzek_et_al-2019-CPT__Pharmacometrics_&_Systems_Pharmacology.pdf
https://eprints.whiterose.ac.uk/153749/1/Kierzek_et_al-2019-CPT__Pharmacometrics_&_Systems_Pharmacology.pdf
Publikováno v:
European Journal of Pharmaceutical Sciences. 109:S140-S148
A key element of the drug discovery process is target selection. Although the topic is subject to much discussion and experimental effort, there are no defined quantitative rules around optimal selection. Often 'rules of thumb', that have not been su
Autor:
Neil Benson
Publikováno v:
Handbook of Biomarkers and Precision Medicine ISBN: 9780429202872
Handbook of Biomarkers and Precision Medicine
Handbook of Biomarkers and Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667adf116e6ef6028cadabebfd85d271
https://doi.org/10.1201/9780429202872-6
https://doi.org/10.1201/9780429202872-6
Autor:
Sophie Postel-Vinay, Flavio Ewerton, Matthias Ocker, Neil Benson, Jean-Charles Soria, Martine Poelman, Karin H Herbschleb, Gary Wilkinson, Mark R. Middleton, Victoria K Woodcock, Annette O. Walter, Christophe Massard
Publikováno v:
European Journal of Cancer. 109
Background: Bromodomain and extraterminal motif (BET) protein inhibition is a promising cancer treatment strategy, notably for targeting MYC- or BRD4-driven diseases. A first-in-human study investigated the safety, pharmacokinetics, maximum tolerated
Autor:
Piet H. van der Graaf, Oleg Demin, Neil Benson, S.V. Vinogradova, Tatiana Karelina, Kirill Zhudenkov
Publikováno v:
Journal of Theoretical Biology. 382:91-98
Mathematical models have been widely used for understanding the dynamics of the hepatitis C virus (HCV). We propose a method to predict final clinical outcome for 24 HIV–HCV - coinfected patients with the help of a mathematical model based on the f
Autor:
Piet H. van der Graaf, Neil Benson
Publikováno v:
Future Medicinal Chemistry. 6:1731-1734
A recently developed system-pharmacological model for the dynamics of receptor tyrosine kinases is used to compare di erent targets for drug action: one aiming at binding endogenous ligand needed for phosphorylation and another binding re- ceptors at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c1c5d5298283fc9ce38d4b48bca285
https://doi.org/10.1016/j.na.2015.12.009
https://doi.org/10.1016/j.na.2015.12.009
Autor:
Carl Laxton, Nicholas Smith, Martin Howard, Gerwyn Bish, Duncan Hay, Mya C. Smith, James Hitchin, Tram T. Tran, David C. Pryde, Hannah M. Jones, Peter Jones, Nigel Horscroft, Gemma C. Parsons, Rachel Dixon, Frederick Calo, Katie J. W. Proctor, Fox David Nathan Abraham, Jonathan Duckworth, Neil Benson, Amy Thomas, Iain Gardner, Tanya Parkinson, Fiona M. Adam, Guiseppe Ciaramella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2389-2393
The synthesis and structure-activity relationships of a series of novel interferon inducers are described. Pharmacokinetic studies and efficacy assessment of a series of 8-oxo-3-deazapurine analogues led to the identification of compound 33, a potent