Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Neil Bence"'
Autor:
Yifeng Xia, Xiaodong Ji, In Sock Jang, Christine Surka, Christy Hsu, Kai Wang, Mark Rolfe, Neil Bence, Gang Lu
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 los
Externí odkaz:
https://doaj.org/article/4d8d29c70bdc4a77a7632fc27bcf2dfd
Autor:
Xingyue He, Jessica Riceberg, Sai M Pulukuri, Steve Grossman, Vaishali Shinde, Pooja Shah, James E Brownell, Larry Dick, John Newcomb, Neil Bence
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123882 (2015)
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates important cellular processes including chromosome structure, kinetochore function, chromosome segregation, nuclear and sub-nuclear organization, transcript
Externí odkaz:
https://doaj.org/article/13e1cfa28eb7421c9e7186a4338a176c
Autor:
Christy Hsu, In Sock Jang, Kai Wang, Gang Lu, Neil Bence, Christine Surka, Yifeng Xia, Mark Rolfe, Xiaodong Ji
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Communications Biology
Communications Biology
The multiplexed cancer cell line screening platform PRISM demonstrated its utility in testing hundreds of cell lines in a single run, possessing the potential to speed up anti-cancer drug discovery, validation and optimization. Here we described the
Autor:
Paul A. Barsanti, Joshua Taygerly, Kathleen Boyle, Kyle R. Simonetta, Stephanie L. Yung, Szerenke Kiss von Soly, Chris Padovani, Frank Kayser, Neil Bence, Anjanabha Saha, Stephen E. Basham, John Kuriyan, Mark Gallop, Thomas Cummins, Yan Lou, Michael Rape, Mario G. Cardozo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Simonetta, Kyle R; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E; Padovani, Chris; Lou, Yan; et al.(2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.. Nature communications, 10(1), 1402. doi: 10.1038/s41467-019-09358-9. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/26s7m3b9
Nature Communications
Nature communications, vol 10, iss 1
Simonetta, Kyle R; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E; Padovani, Chris; Lou, Yan; et al.(2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.. Nature communications, 10(1), 1402. doi: 10.1038/s41467-019-09358-9. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/26s7m3b9
Protein–protein interactions (PPIs) governing the recognition of substrates by E3 ubiquitin ligases are critical to cellular function. There is significant therapeutic potential in the development of small molecules that modulate these interactions
Autor:
Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles
Publikováno v:
Journal of medicinal chemistry. 64(5)
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first ste
Autor:
Christoph W. Zapf, May Tan, Mario G. Cardozo, Ge Peng, Jennifer Tung, Mcintosh Joel, Arthur T. Sands, Ryan Rountree, Zef Konst, Jordan Ye, Aileen Kelly, Jeffrey H. Wu, Luz Perez, Neil Bence, Timothy Ingallinera, Dahlia Weiss, Mark Noviski, Steve Basham, Austin Tenn-McClellan, Jenny McKinnell, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic, Daniel W. Robbins, Dane E Karr
Publikováno v:
Blood. 134:3805-3805
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor signaling and is involved in B cell development and function. BTK plays a crucial role in cell survival in B cell malignancies such as Chronic Lymphocytic Leukemia (CLL), and covale
Autor:
Arthur T. Sands, Hailey Harris, Sarah E. M. Herman, Neil Bence, Adrian Wiestner, Aileen Kelly, Sivasubramanian Baskar, May Tan, Timothy Ingallinera, Daniel W. Robbins, Deyi Zhang
Publikováno v:
Blood. 134:174-174
B-cell receptor (BCR) signaling plays an essential role in normal B-cell development and is a key driver of proliferation and survival of chronic lymphocytic leukemia (CLL) B cells. BCR signals through BTK to NF-ĸB. Targeted inhibition of BTK with i
Publikováno v:
Mutation Research/DNA Repair. 384:145-156
Exposure to alkylating agents results in the formation of a wide variety of DNA damage products. One of these, 3-methyladenine (3-mAde), is lethal if left unrepaired. The 3-methyladenine glycosylase (aMAG) gene of Arabidopsis thaliana is required for
Autor:
Xiaofeng Yang, Michael Milhollen, Neil Bence, Mark Manfredi, Huay-Keng Loke, Erik Koenig, James E. Brownell, Mike Sintchak, Michael P. Thomas, Usha Narayanan, Qing Xu, James M. Gavin, Jessica Riceberg, Alice McDonald, Joseph B. Bolen, Benjamin S. Amidon, Peter G. Smith, Sells Todd B, Tary Traore, Jingya Ma, Lawrence R. Dick
Publikováno v:
Cancer cell. 21(3)
SummaryMLN4924 is an investigational small-molecule inhibitor of NEDD8-activating enzyme (NAE) in clinical trials for the treatment of cancer. MLN4924 is a mechanism-based inhibitor, with enzyme inhibition occurring through the formation of a tight-b
Autor:
Nathan Hedin, Richard A. Klinghoffer, Neil Bence, Beryl A. Hatton, Stephen J. Blakemore, Mark Manfredi, Nathan Caffo, Marc Grenley, Marc Hyer
Publikováno v:
Cancer Research. 73:4153-4153
Presage technology enables simultaneous analysis of multiple cancer drug candidates, drug concentrations, and drug combinations within a single living tumor. The platform employs arrayed tumor microinjection technology that delivers multiple spatiall