Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Neil Beeharry"'
Autor:
Neil Beeharry, Sean Landrette, Sophia Gayle, Marylens Hernandez, Jeff E. Grotzke, Peter R. Young, Paul Beckett, Xuan Zhang, Bing Z. Carter, Michael Andreeff, Stephanie Halene, Tian Xu, Jonathan Rothberg, Henri Lichenstein
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3661-3673 (2019)
Abstract: Acute myeloid leukemias (AML) harboring a constitutively active internal tandem duplication (ITD) mutation in the FMS-like kinase tyrosine kinase (FLT3) receptor are associated with poor patient prognosis. Despite initial clinical responses
Externí odkaz:
https://doaj.org/article/10809012eaf34849adb24b33824a7b68
Autor:
Andrea Ghelli Luserna Di Rorà, Neil Beeharry, Enrica Imbrogno, Anna Ferrari, Valentina Robustelli, Simona Righi, Elena Sabattini, Maria Vittoria Verga Falzacappa, Chiara Ronchini, Nicoletta Testoni, Carmen Baldazzi, Cristina Papayannidis, Maria Chiara Abbenante, Giovanni Marconi, Stefania Paolini, Sarah Parisi, Chiara Sartor, Maria Chiara Fontana, Serena De Matteis, Ilaria Iacobucci, Pier Giuseppe Pelicci, Michele Cavo, Timothy J. Yen, Giovanni Martinelli
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-18 (2018)
Abstract Background Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases. Several studies in solid tumors identified high expression of
Externí odkaz:
https://doaj.org/article/8f069026414740328164d96468bffa2f
Autor:
Andrea Ghelli Luserna Di Rorà, Matteo Bocconcelli, Anna Ferrari, Carolina Terragna, Samantha Bruno, Enrica Imbrogno, Neil Beeharry, Valentina Robustelli, Martina Ghetti, Roberta Napolitano, Gabriella Chirumbolo, Giovanni Marconi, Cristina Papayannidis, Stefania Paolini, Chiara Sartor, Giorgia Simonetti, Timothy J. Yen, Giovanni Martinelli
Publikováno v:
Cancers, Vol 11, Iss 11, p 1654 (2019)
Introduction: Screening for synthetic lethality markers has demonstrated that the inhibition of the cell cycle checkpoint kinases WEE1 together with CHK1 drastically affects stability of the cell cycle and induces cell death in rapidly proliferating
Externí odkaz:
https://doaj.org/article/5f996cc5af8b47eb9c95c8c16b7f47e6
Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens.
Autor:
Oana Ursu, Sara J C Gosline, Neil Beeharry, Lauren Fink, Vikram Bhattacharjee, Shao-Shan Carol Huang, Yan Zhou, Tim Yen, Ernest Fraenkel
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185650 (2017)
Small molecule screens are widely used to prioritize pharmaceutical development. However, determining the pathways targeted by these molecules is challenging, since the compounds are often promiscuous. We present a network strategy that takes into ac
Externí odkaz:
https://doaj.org/article/c5dacd65383e474d8521872df90c9ffa
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40342 (2012)
Bendamustine (BDM) is an active chemotherapeutic agent approved in the U. S. for treating chronic lymphocytic leukemia and non-Hodgkin lymphoma. Its chemical structure suggests it may have alkylator and anti-metabolite activities; however the precise
Externí odkaz:
https://doaj.org/article/76c40c65dfec445bb0ad1f8599eb68bd
Autor:
Maureen E. Murphy, Donna L. George, Tim Yen, Roland L. Dunbrack, Jessie Villanueva, Meenhard Herlyn, Gao Zhang, Mark D. Andrake, Seth Hayik, Neil Beeharry, Julia I.-Ju Leu, Gregor M. Balaburski
PDF file - 130K, A) Chemical structure of biotinylated PES B) Chemical structure of PES and derivatives NSC85560, NSC166772 and NSC303578 (nomenclature is from the National Cancer Institute Drug Repository). C) Cell viability of H1299 and PANC1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de7b1efb4cbb6c7db23a51d94ef5d0a
https://doi.org/10.1158/1541-7786.22509972
https://doi.org/10.1158/1541-7786.22509972
Autor:
Maureen E. Murphy, Donna L. George, Tim Yen, Roland L. Dunbrack, Jessie Villanueva, Meenhard Herlyn, Gao Zhang, Mark D. Andrake, Seth Hayik, Neil Beeharry, Julia I.-Ju Leu, Gregor M. Balaburski
PDF file - 395K, A) Binding assays of H1299 cells transfected with HA-tagged full-length and truncated HSP70 encoding the amino acids (aa) shown, treated with 20 uM biotinylated PES (B-PES) and 20 uM PES-Cl (PES-Cl). Biotinylated PES complexes were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aba85d6b3700b8dbb389e243757e4bf
https://doi.org/10.1158/1541-7786.22509963
https://doi.org/10.1158/1541-7786.22509963
Autor:
Maureen E. Murphy, Donna L. George, Tim Yen, Roland L. Dunbrack, Jessie Villanueva, Meenhard Herlyn, Gao Zhang, Mark D. Andrake, Seth Hayik, Neil Beeharry, Julia I.-Ju Leu, Gregor M. Balaburski
PDF file - 45K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac330d2d0a57db3e6595a976eb7d578
https://doi.org/10.1158/1541-7786.22509960
https://doi.org/10.1158/1541-7786.22509960
Autor:
Maureen E. Murphy, Donna L. George, Tim Yen, Roland L. Dunbrack, Jessie Villanueva, Meenhard Herlyn, Gao Zhang, Mark D. Andrake, Seth Hayik, Neil Beeharry, Julia I.-Ju Leu, Gregor M. Balaburski
The stress-induced HSP70 is an ATP-dependent molecular chaperone that plays a key role in refolding misfolded proteins and promoting cell survival following stress. HSP70 is marginally expressed in nontransformed cells, but is greatly overexpressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5831e01dfb9f964d953582a0c6090e8
https://doi.org/10.1158/1541-7786.c.6539460
https://doi.org/10.1158/1541-7786.c.6539460
Autor:
Maureen E. Murphy, Donna L. George, Tim Yen, Roland L. Dunbrack, Jessie Villanueva, Meenhard Herlyn, Gao Zhang, Mark D. Andrake, Seth Hayik, Neil Beeharry, Julia I.-Ju Leu, Gregor M. Balaburski
PDF file - 280K, A) Chemical structures of PES and synthesized derivatives. P=pyrrolidine; CM= carboxymethyl; Cl=chloride. B) MTT cell viability analyses of H1299 and PANC1 cells after 48 hour treatment with 10 uM PES, PES-P, PES-PCM and PES-PCl. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334adae23d57fa2d3e4615c521390d4e
https://doi.org/10.1158/1541-7786.22509969.v1
https://doi.org/10.1158/1541-7786.22509969.v1