Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Neil B Ruderman"'
Autor:
Émilie Pepin, Anfal Al-Mass, Camille Attané, Kezhuo Zhang, Julien Lamontagne, Roxane Lussier, S R Murthy Madiraju, Erik Joly, Neil B Ruderman, Robert Sladek, Marc Prentki, Marie-Line Peyot
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153017 (2016)
Diet induced obese (DIO) mice can be stratified according to their weight gain in response to high fat diet as low responders (LDR) and high responders (HDR). This allows the study of β-cell failure and the transitions to prediabetes (LDR) and early
Externí odkaz:
https://doaj.org/article/a816a82e402c4a1b82063292ec35e8b2
Autor:
Amanda E Brandon, Jennifer Tid-Ang, Lauren E Wright, Ella Stuart, Eurwin Suryana, Nicholas Bentley, Nigel Turner, Gregory J Cooney, Neil B Ruderman, Edward W Kraegen
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121959 (2015)
SIRT1 is a NAD+-dependent deacetylase thought to regulate cellular metabolic pathways in response to alterations in nutrient flux. In the current study we investigated whether acute changes in SIRT1 expression affect markers of muscle mitochondrial c
Externí odkaz:
https://doaj.org/article/fe8e9fdd3cf54d85aa3beb4e30f56ed1
Autor:
Kimberly A Coughlan, Thomas W Balon, Rudy J Valentine, Robert Petrocelli, Vera Schultz, Amanda Brandon, Gregory J Cooney, Edward W Kraegen, Neil B Ruderman, Asish K Saha
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127388 (2015)
We have previously shown that incubation for 1h with excess glucose or leucine causes insulin resistance in rat extensor digitorum longus (EDL) muscle by inhibiting AMP-activated protein kinase (AMPK). To examine the events that precede and follow th
Externí odkaz:
https://doaj.org/article/77dc1e82d919441083a9ad124737ee02
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115341 (2015)
The aging process is perceived as resulting from a combination of intrinsic factors such as changes in intracellular signaling and extrinsic factors, most notably environmental stressors. In skin, the relationship between intrinsic changes and kerati
Externí odkaz:
https://doaj.org/article/5d12ad145c454a4a9f2181ddba1209e4
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97554 (2014)
Liraglutide is a glucagon-like peptide-1 (GLP-1) mimetic used for the treatment of Type 2 diabetes. Similar to the actions of endogenous GLP-1, liraglutide potentiates the post-prandial release of insulin, inhibits glucagon release and increases sati
Externí odkaz:
https://doaj.org/article/cfb633e8fc8e4d2d9bb85f4bbac16ef0
Autor:
Yasuo Ido, Albert Duranton, Fan Lan, Jose M Cacicedo, Tai C Chen, Lionel Breton, Neil B Ruderman
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35092 (2012)
We investigated the effects of AMPK on H(2)O(2)-induced premature senescence in primary human keratinocytes. Incubation with 50 µM H(2)O(2) for 2 h resulted in premature senescence with characteristic increases in senescence-associated ß-galactosid
Externí odkaz:
https://doaj.org/article/bbb3f39fdc9e4de9a24b993ab77d4366
Autor:
X. Julia Xu, Marie-Soleil Gauthier, Donald T. Hess, Caroline M. Apovian, Jose M. Cacicedo, Noyan Gokce, Melissa Farb, Rudy J. Valentine, Neil B. Ruderman
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 4, Pp 792-801 (2012)
We previously reported that adenosine monophosphate-activated protein kinase (AMPK) activity is lower in adipose tissue of morbidly obese individuals who are insulin resistant than in comparably obese people who are insulin sensitive. However, the nu
Externí odkaz:
https://doaj.org/article/eeafa9bcf3454cd9b2b19fbb35013336
Autor:
Rudy J. Valentine, Katherine Allen, Asish K. Saha, Kimberly A. Coughlan, Neil B. Ruderman, Fabliha N. Mahmood
Publikováno v:
Archives of Biochemistry and Biophysics. :49-57
AMP-activated protein kinase (AMPK) is an enzyme crucial in cellular metabolism found to be inhibited in many metabolic diseases including type 2 diabetes. Thiazolidinediones (TZDs) are a class of anti-diabetic drug known to activate AMPK through inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919244bb15ae13fb2792610f9d68ccb3
https://doi.org/10.1016/j.abb.2017.05.010
https://doi.org/10.1016/j.abb.2017.05.010
Autor:
Yossi Dagon, Barbara B. Kahn, Rudy J. Valentine, Bella S. Sudit, Asish K. Saha, Neil B. Ruderman, Katherine Allen, Kimberly A. Coughlan
Publikováno v:
Journal of Biological Chemistry. 291:5664-5675
AMP-activated protein kinase (AMPK) is an energy-sensing enzyme whose activity is inhibited in settings of insulin resistance. Exposure to a high glucose concentration has recently been shown to increase phosphorylation of AMPK at Ser(485/491) of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c459fca49ca1d7194ba3dca6c6868aa
https://doi.org/10.1074/jbc.m115.696849
https://doi.org/10.1074/jbc.m115.696849
Autor:
Asish K. Saha, Neil B. Ruderman, Donald T. Hess, X. Julia Xu, Brian Carmine, Caroline M. Apovian
Publikováno v:
Diabetes
Morbidly obese individuals are predisposed to a wide range of disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, fatty liver disease, and certain cancers. Remarkably, all of these disorders can be improved or prevented by R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c366c24e178985b4163baa9c52b7ab2
https://doi.org/10.2337/db14-1765
https://doi.org/10.2337/db14-1765