Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Neil Andrew Dunbar"'
Autor:
Jean-Yves Christophe Chiva, Peter Pyun, Andrew John Keats, Linos Lazarides, Karine G. Poullennec, Neil Andrew Dunbar, Brian E. Schultz, Mingzhe Ji, Gregory M. Watt, Karki Kapil Kumar, Ruby Cai, Carina E. Cannizzaro, Uli Schmitz, David Kenneth Dean, Yu-Jen Lee, Sangi Michael, Victoria Alexandra Steadman, Adam J. Schrier, Simon B. Pettit, Hans G. Fliri, Adrian John Highton, Todd C. Appleby, Carol Austin, Richard L. Mackman, Caroline A. Blakemore, Hui Hon Chung, Dustin Siegel, Gregory Chin, Bernard P. Murray, Hai Yang, Yang Tian, George Stepan, Jonathan Sanvoisin, Albert Liclican, Mish Michael R, David Sperandio, Rex Santos, Petr Jansa, Haolun Jin
Publikováno v:
Journal of Medicinal Chemistry. 61:9473-9499
Cyclophilins are a family of peptidyl-prolyl isomerases that are implicated in a wide range of diseases including hepatitis C. Our aim was to discover through total synthesis an orally bioavailable, non-immunosuppressive cyclophilin (Cyp) inhibitor w
Autor:
Dawn Buchanan, Joanna Passmore, Anders Haunsø, Matilda Bingham, Linsday Gibson, Margaret Huggett, Olaf Nimz, Richard Goodwin, Neil Andrew Dunbar, Susan Elizabeth Napier, Derek Angus, Richard Morphy, Andrea K. Houghton, Glenn Walker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:271-275
Hit compound 1, a selective noradrenaline re-uptake transporter (NET) inhibitor was optimised to build in potency at the serotonin re-uptake transporter (SERT) whilst maintaining selectivity against the dopamine re-uptake transporter (DAT). During th