Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Neil AJ Ryan"'
Autor:
Tristan M Snowsill, Helen Coelho, Nia G Morrish, Simon Briscoe, Kate Boddy, Tracy Smith, Emma J Crosbie, Neil AJ Ryan, Fiona Lalloo, Claire T Hulme
Publikováno v:
Health Technology Assessment, Vol 28, Iss 41 (2024)
Background Lynch syndrome is an inherited condition which leads to an increased risk of colorectal, endometrial and ovarian cancer. Risk-reducing surgery is generally recommended to manage the risk of gynaecological cancer once childbearing is comple
Externí odkaz:
https://doaj.org/article/9c92c775bf684eed9a9b8c11b626f0ee
Publikováno v:
Georgiou, D, Monje-Garcia, L, Miles, T, Monahan, K & Ryan, N AJ 2023, ' A Focused Clinical Review of Lynch Syndrome ', Cancer Management and Research, vol. 15, pp. 67-85 . https://doi.org/10.2147/CMAR.S283668
Lynch syndrome (LS) is an autosomal dominant condition that increases an individual's risk of a constellation of cancers. LS is defined when an individual has inherited pathogenic variants in the mismatch repair genes. Currently, most people with LS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1cd789c682f65de4d0212398c235b4
http://hdl.handle.net/10044/1/102640
http://hdl.handle.net/10044/1/102640
Autor:
Mark A Glaire, Neil AJ Ryan, Marieke E Ijsselsteijn, Katarzyna Kedzierska, Sofia Obolenski, Reem Ali, Emma J Crosbie, Tjalling Bosse, Noel FCC Miranda, David N Church
Publikováno v:
Glaire, M A, Ryan, N A, Ijsselsteijn, M E, Kedzierska, K, Obolenski, S, Ali, R, Crosbie, E, Bosse, T, De Miranda, N F & Church, D N 2022, ' Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape ', The Journal of pathology . https://doi.org/10.1002/path.5894
The Journal of Pathology, 257(3), 340-351. WILEY
The Journal of Pathology, 257(3), 340-351. WILEY
Defective DNA mismatch repair (dMMR) causes elevated tumour mutational burden (TMB) and microsatellite instability (MSI) in multiple cancer types. dMMR/MSI colorectal cancers (CRCs) have enhanced T-cell infiltrate and favourable outcome; however, thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a85aa336529f0da2168225838017b8
https://hdl.handle.net/1887/3505660
https://hdl.handle.net/1887/3505660