Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Neil A. J. Ryan"'
Autor:
Timothy S. Fitzsimmons, Niharika Singh, Thomas D. J. Walker, Claire Newton, Dafydd G. R. Evans, Emma J. Crosbie, Neil A. J. Ryan
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundImmune checkpoint inhibitors (ICPI) are a tumor agnostic treatment. However, trials of their use have been site specific. Here we summarize the trial data and explore the utility of programmed death-ligand 1 (PD-L1) expression as a biomarke
Externí odkaz:
https://doaj.org/article/e85e6a4434f447a39ab6c4448e66752b
Diagnostic accuracy of cytology for the detection of endometrial cancer in urine and vaginal samples
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Postmenopausal bleeding can be an indication of endometrial cancer. Here, the authors combine cytology of urine and vaginal samples from women with postmenopausal bleeding and demonstrate that they can accurately predict endometrial cancer with a sen
Externí odkaz:
https://doaj.org/article/b5bebe5f28504455b7f240bf8c2cfd28
Autor:
Neal C. Ramchander, Neil A. J. Ryan, Thomas D. J. Walker, Lauren Harries, James Bolton, Tjalling Bosse, D. G. Evans, Emma J. Crosbie
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Around 30% of endometrial cancers (EC) are mismatch repair (MMR) deficient, mostly as a consequence of mutations acquired during tumorigenesis, but a significant minority is caused by Lynch syndrome (LS). This inherited cancer predisposition syndrome
Externí odkaz:
https://doaj.org/article/feb8adc93b1e445eb2b31f037913d8d9
Autor:
Neil A. J. Ryan, Dominic Blake, Marcus Cabrera-Dandy, Mark A. Glaire, D. Gareth Evans, Emma J. Crosbie
Publikováno v:
Systematic Reviews, Vol 7, Iss 1, Pp 1-6 (2018)
Abstract Background Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer. The early diagnosis of Lynch syndrome enables colorectal s
Externí odkaz:
https://doaj.org/article/00952b47c829455182c56b630ba5a081
Autor:
Chloe E. Barr, Kelechi Njoku, Leo Hotchkies, Neil A. J. Ryan, Y. Louise Wan, David A. Davies, Salman Razvi, Emma J. Crosbie
Publikováno v:
Cancers, Vol 13, Iss 21, p 5444 (2021)
Endometrial cancer is the commonest gynaecological malignancy in developed countries, and women presenting with high risk or advanced disease have poor outcomes. Thyroid hormones play a key role in cellular metabolism and can influence cancer growth
Externí odkaz:
https://doaj.org/article/bd7b8a1842b044288ec3402154b7e7cc
Autor:
Neil A. J. Ryan, Thomas D. J. Walker, James Bolton, Natalja ter Haar, Tom Van Wezel, Mark A. Glaire, David N. Church, D. Gareth Evans, Tjalling Bosse, Emma J. Crosbie
Publikováno v:
Cancers, Vol 13, Iss 18, p 4538 (2021)
Background: Mismatch repair deficient (MMRd) tumours may arise from somatic events acquired during carcinogenesis or in the context of Lynch syndrome (LS), an inherited cancer predisposition condition caused by germline MMR pathogenic variants. Our a
Externí odkaz:
https://doaj.org/article/546241e5620b422dbcd9cb799cdc2212
Autor:
Neil A. J. Ryan, Niall J. Davison, Katherine Payne, Anne Cole, D. Gareth Evans, Emma J. Crosbie
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Lynch syndrome is the most common inherited cause of endometrial cancer. Identifying individuals affected by Lynch syndrome enables risk-reducing interventions including colorectal surveillance, and cascade testing of relatives.Methods: W
Externí odkaz:
https://doaj.org/article/8b1deb1ad9d047af9e4c62084663c7af
Autor:
Mev Dominguez-Valentin, Toni T. Seppälä, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H Sijmons, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Giulia Martina Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Kate Green, Fiona Lalloo, James Hill, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Hans-Georg Strauß, Johanna Tecklenburg, Elke Holinski-Feder, Verena Steinke-Lange, Jukka-Pekka Mecklin, John-Paul Plazzer, Marta Pineda, Matilde Navarro, Joan Brunet Vidal, Revital Kariv, Guy Rosner, Tamara Alejandra Piñero, María Laura Gonzalez, Pablo Kalfayan, Julian R. Sampson, Neil A. J. Ryan, D. Gareth Evans, Pål Møller, Emma J. Crosbie
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 7, p 2290 (2020)
Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the P
Externí odkaz:
https://doaj.org/article/364a64ae89914628912a34dbaf520af6
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 6, p 1664 (2020)
Lynch syndrome (LS) is a hereditary cancer syndrome responsible for 3% of all endometrial cancer and 5% in those aged under 70 years. It is unclear whether universal testing for LS in endometrial cancer patients would be cost-effective. The Mancheste
Externí odkaz:
https://doaj.org/article/149c7d51baab4510a035e21708aa2ef3
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 6, p 1842 (2020)
A barrier to Lynch syndrome testing is the need for prior genetic counselling, a resource demanding process for both patients and healthcare services. We explored the impact of gynaecologist led Lynch syndrome testing in women with endometrial cancer
Externí odkaz:
https://doaj.org/article/ce426553fe8d451885b6074a4404070d