Diagnostic accuracy of cytology for the detection of endometrial cancer in urine and vaginal samples

Autor: Helena O’Flynn, Neil A. J. Ryan, Nadira Narine, David Shelton, Durgesh Rana, Emma J. Crosbie

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

Postmenopausal bleeding can be an indication of endometrial cancer. Here, the authors combine cytology of urine and vaginal samples from women with postmenopausal bleeding and demonstrate that they can accurately predict endometrial cancer with a sen

Externí odkaz: https://doaj.org/article/b5bebe5f28504455b7f240bf8c2cfd28

The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol

Autor: Neil A. J. Ryan, Dominic Blake, Marcus Cabrera-Dandy, Mark A. Glaire, D. Gareth Evans, Emma J. Crosbie

Publikováno v: Systematic Reviews, Vol 7, Iss 1, Pp 1-6 (2018)

Abstract Background Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer. The early diagnosis of Lynch syndrome enables colorectal s

Externí odkaz: https://doaj.org/article/00952b47c829455182c56b630ba5a081

Weight Loss During Intrauterine Progestin Treatment for Obesity-associated Atypical Hyperplasia and Early-Stage Cancer of The Endometrium

Autor: Rhona J McVey, Y Louise Wan, Akheel A. Syed, Michelle L. MacKintosh, Chloe E Barr, Neil A J Ryan, James Bolton, Richard J Slade, Dina Awad, Abigail E. Derbyshire, Cheryl T. Fitzgerald, Basil J. Ammori, Emma J Crosbie

Publikováno v: Cancer Prevention Research. 14:1041-1050

Intrauterine progestin is a treatment option for women with atypical hyperplasia or low-risk endometrial cancer who wish to preserve their fertility, or whose poor surgical fitness precludes safe hysterectomy. We hypothesized that in such women with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a787bfa56743e7db94ea7e8f2c6733e6
https://doi.org/10.1158/1940-6207.capr-21-0229

Synchronous uterine and bladder cancers detected in urine and vaginal samples by cytology

Autor: Neil A J Ryan, Helena O'Flynn, Nadira Narine, Dina Awad, Durgesh Rana, David Shelton, Emma J Crosbie, Eleanor R Jones

Publikováno v: Narine, N, Rana, D, Shelton, D, Awad, D, O'Flynn, H, Jones, E R, Ryan, N & Crosbie, E 2022, ' Synchronous uterine and bladder cancers detected in urine and vaginal samples by cytology ', Diagnostic Cytopathology . https://doi.org/10.1002/dc.24906

Novel diagnostics for uterine cancer are urgently needed to reduce the burden of invasive testing for the majority of healthy women with postmenopausal bleeding. We have previously shown that uterine cancer cells can be detected by cytology in urine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969a3e471fb478e03fc48bf223d45e0c
https://pubmed.ncbi.nlm.nih.gov/34783454

Histological and somatic mutational profiles of mismatch repair deficient endometrial tumours of different aetiologies

Autor: Tjalling Bosse, Thomas D. J. Walker, D. Gareth Evans, James Bolton, Tom van Wezel, Natalja T. ter Haar, Neil A J Ryan, Mark A. Glaire, David N. Church, Emma J Crosbie

Publikováno v: Cancers, 13(18). MDPI
Cancers
Ryan, N A J, Walker, T D J, Bolton, J, Haar, N T, Wezel, T V, Glaire, M A, Church, D N, Evans, D G, Bosse, T & Crosbie, E J 2021, ' Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies ', Cancers . https://doi.org/10.3390/cancers13184538
Cancers, Vol 13, Iss 4538, p 4538 (2021)
Ryan, N A J, Walker, T D J, Bolton, J, Haar, N T, Wezel, T V, Glaire, M A, Church, D N, Evans, D G, Bosse, T & Crosbie, E J 2021, ' Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies ', Cancers, vol. 13, no. 18, 4538 . https://doi.org/10.3390/cancers13184538
Volume 13
Issue 18

Background: Mismatch repair deficient (MMRd) tumours may arise from somatic events acquired during carcinogenesis or in the context of Lynch syndrome (LS), an inherited cancer predisposition condition caused by germline MMR pathogenic variants. Our a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198b95d5a4a5b6489c7d610fb4fa01ac
http://hdl.handle.net/1887/3250658