Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Neil A. Hukriede"'
Autor:
Ailen S. Cervino, Mariano G. Collodel, Ivan A. Lopez, Carolina Roa, Daniel Hochbaum, Neil A. Hukriede, M. Cecilia Cirio
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The nephron, functional unit of the vertebrate kidney, is specialized in metabolic wastes excretion and body fluids osmoregulation. Given the high evolutionary conservation of gene expression and segmentation patterning between mammalian and
Externí odkaz:
https://doaj.org/article/089ae6f0fc5d4ab59f9a14008960313a
Autor:
Aneta Przepiorski, Thitinee Vanichapol, Eugenel B. Espiritu, Amanda E. Crunk, Emily Parasky, Michael D. McDaniels, Dave R. Emlet, Ryan Salisbury, Cassandra L. Happ, Lawrence A. Vernetti, Matthew L. MacDonald, John A. Kellum, Thomas R. Kleyman, Catherine J. Baty, Alan J. Davidson, Neil A. Hukriede
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Background Hemolysis occurs in many injury settings and can trigger disease processes. In the kidney, extracellular hemoglobin can induce damage via several mechanisms. These include oxidative stress, mitochondrial dysfunction, and inflammat
Externí odkaz:
https://doaj.org/article/ed6e39b445874502af0c45f7b56b6278
Autor:
Xiaoyan Wen, Shengnan Li, Alicia Frank, Xiukai Chen, David Emlet, Neil A. Hukriede, John A. Kellum
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Background Sepsis, a dysregulated host response to infection with results in organ dysfunction, has been a major challenge to the development of effective therapeutics. Sepsis-associated acute kidney injury (S-AKI) results in a 3–5-fold in
Externí odkaz:
https://doaj.org/article/f6f7455ff4824854b16695b93e510f3b
Autor:
Gerard J. Nau, Joseph Horzempa, Dawn O’Dee, Matthew J. Brown, Brian C. Russo, Ana Hernandez, Simon T. Dillon, Jing Cheng, Lawrence P. Kane, Subramaniam Sanker, Neil A. Hukriede
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 643-656 (2019)
Pathogens enhance their survival during infections by manipulating host defenses. Francisella tularensis evades innate immune responses, which we have found to be dependent on an understudied gene ybeX (FTL_0883/FTT_0615c). To understand the function
Externí odkaz:
https://doaj.org/article/53a0193c29d24e789078a350b2142165
Autor:
Veronika Sander, Aneta Przepiorski, Amanda E. Crunk, Neil A. Hukriede, Teresa M. Holm, Alan J. Davidson
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100150- (2020)
Summary: Kidney organoids represent a physiologically advanced model for studying the mechanisms of kidney development and disease. Here, we describe a simple two-step protocol for the differentiation of human pluripotent stem cells into kidney organ
Externí odkaz:
https://doaj.org/article/2781ad0fc39e463ebce730d990f53b97
Autor:
Lauren Brilli Skvarca, Hwa In Han, Eugenel B. Espiritu, Maria A. Missinato, Elizabeth R. Rochon, Michael D. McDaniels, Abha S. Bais, Beth L. Roman, Joshua S. Waxman, Simon C. Watkins, Alan J. Davidson, Michael Tsang, Neil A. Hukriede
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 4 (2019)
Acute kidney injury (AKI) is a serious disorder for which there are limited treatment options. Following injury, native nephrons display limited regenerative capabilities, relying on the dedifferentiation and proliferation of renal tubular epithelial
Externí odkaz:
https://doaj.org/article/e07c8956261544919ae06d1bac3c4d12
Autor:
Richard W. Naylor, Lauren Brilli Skvarca, Christine Thisse, Bernard Thisse, Neil A. Hukriede, Alan J. Davidson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
It is unclear how the dorsal-ventral (DV) and anterior-posterior (AP) axes established in the gastrula affect tissues. Here, the authors show that in zebrafish kidney development, with regard to non-axial mesoderm, the classic DV axis corresponds to
Externí odkaz:
https://doaj.org/article/6c5070ea131a42e6a2bce0a514006ddf
Autor:
Nicolas Montalbetti, Aneta J. Przepiorski, Shujie Shi, Shaohu Sheng, Catherine J. Baty, Joseph C. Maggiore, Marcelo D. Carattino, Thitinee Vanichapol, Alan J. Davidson, Neil A. Hukriede, Thomas R. Kleyman
Publikováno v:
American Journal of Physiology-Renal Physiology. 323:F479-F491
Kidney organoids derived from human or rodent pluripotent stem cells have glomerular structures and differentiated/polarized nephron segments. Although there is an increasing understanding of the patterns of expression of transcripts and proteins wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43c05793e2fb3fc5d3fba317145db1f
https://doi.org/10.1152/ajprenal.00365.2021
https://doi.org/10.1152/ajprenal.00365.2021
Autor:
Joseph C Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Evan Streeter, Anne Silva-Barbosa, Jonathan Franks, Joshua Hislop, Alex Hill, Haojia Wu, Katherine Pfister, Sara E Howden, Simon C Watkins, Melissa Little, Benjamin Humphreys, Alan Watson, Donna B Stolz, Samira Kiani, Alan J Davidson, Thomas J. Carroll, Ondine J. Cleaver, Sunder Sims-Lucas, Mo R Ebrahimkhani, Neil A Hukriede
Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation in a clinical setting thereby hinges on achieving robust vascularization of in vitro engineered organs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a832bb2fd956b83cba53f6fdf775582
https://doi.org/10.1101/2023.05.30.542848
https://doi.org/10.1101/2023.05.30.542848
Autor:
Andreas Vogt, Billy W. Day, Dennis P. Curran, Neil A. Hukriede, John S. Lazo, Celeste E. Reese, Raghavan Balachandran, Hikmat N. Daghestani, Wei Zhu, Daniel P. Camarco, Maria Jiménez, Laura L. Vollmer
The natural product (−)-dictyostatin is a microtubule-stabilizing agent that potently inhibits the growth of human cancer cells, including paclitaxel-resistant clones. Extensive structure–activity relationship studies have revealed several region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecdf80d5efb235382c6a7baaca49a0a2
https://doi.org/10.1158/1535-7163.c.6535479
https://doi.org/10.1158/1535-7163.c.6535479