Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Neil A. Farrow"'
Autor:
Steven J. Taylor, Asitha Abeywardane, Shuang Liang, Zhaoming Xiong, John R. Proudfoot, Bennett Sandy Farmer, Donghong A. Gao, Alexander Heim-Riether, Lana Louise Smith-Keenan, Ingo Muegge, Yang Yu, Qiang Zhang, Donald Souza, Mark Panzenbeck, Daniel Goldberg, Melissa Hill-Drzewi, Mariana Margarit, Brandon Collins, John Xiang Li, Ljiljana Zuvela-Jelaska, Jun Li, Neil A. Farrow
Publikováno v:
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
Externí odkaz:
https://doaj.org/article/28925716e0524cb7af79c7a4126b692b
Autor:
Joshua S. Alford, John W. Lampe, Dorothy Brach, Richard Chesworth, Kat Cosmopoulos, Kenneth W. Duncan, Sean T. Eckley, Jeffrey L. Kutok, Alejandra Raimondi, Thomas V. Riera, Brian Shook, Cuyue Tang, Jennifer Totman, Neil A. Farrow
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1137-1143
SETD2, a lysine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0923d93af3913acf097ff9afc7c6e1
https://doi.org/10.1021/acsmedchemlett.2c00167
https://doi.org/10.1021/acsmedchemlett.2c00167
Autor:
Thomas V. Riera, Lampe John W, Cuyue Tang, Kat Cosmopoulos, Alejandra Raimondi, Michael John Munchhof, Neil A. Farrow, Kenneth W. Duncan, Dorothy Brach, Vinny Motwani, Darren Martin Harvey, P. Ann Boriak-Sjodin, Sean T. Eckley, Jennifer Totman, Joshua S Alford, Megan Alene Cloonan Foley, Michael J Thomenius
Publikováno v:
ACS Medicinal Chemistry Letters
SET domain-containing protein 2 (SETD2), a histone methyltransferase, has been identified as a target of interest in certain hematological malignancies, including multiple myeloma. This account details the discovery of EPZ-719, a novel and potent SET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c70d3b49c7dd565ec207bc48d880872
https://pubmed.ncbi.nlm.nih.gov/34671445
https://pubmed.ncbi.nlm.nih.gov/34671445
Autor:
John Xiang Li, Steven John Taylor, Mariana Margarit, Jun Li, Yu Yang, Qiang Zhang, Ingo Muegge, Melissa Hill-Drzewi, Alexander Heim-Riether, Mark Panzenbeck, Asitha Abeywardane, Zhaoming Xiong, Daniel R. Goldberg, Bennett Sandy Farmer, Gao Donghong A, Ljiljana Zuvela-Jelaska, John R. Proudfoot, Shuang Liang, Donald Souza, Lana Louise Smith-Keenan, Neil A. Farrow, Brandon Collins
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochemical properties to qualify as tool compounds suitable for in vivo testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f527696acc72281bab3399c1433275
https://pubmed.ncbi.nlm.nih.gov/34337203
https://pubmed.ncbi.nlm.nih.gov/34337203
Autor:
Neil A. Farrow, Eugene R. Hickey, Eric T. Larson, Raj Ganesan, Debra L. Brennan, Rachel Kroe-Barrett
Publikováno v:
Protein Science : A Publication of the Protein Society
Cellular signaling via binding of the cytokines IL‐36α, β, and γ along with binding of the accessory protein IL‐36RAcP, to their cognate receptor IL‐36R is believed to play a major role in epithelial and immune cell‐mediated inflammation r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f96e4487f33a4e8a66e3fe51cac061f
https://pubmed.ncbi.nlm.nih.gov/32239732
https://pubmed.ncbi.nlm.nih.gov/32239732
Autor:
Selene Howe, Daniel T. Dransfield, Lampe John W, Kim Stickland, Neil A. Farrow, Dorothy Brach, Kenneth W. Duncan, Suzanne L. Jacques, Allison Drew, Lindsey W. Eichinger, Vinny Motwani, Alejandra Raimondi, Cuyue Tang, Chloe Pantano
Publikováno v:
Cancer Research. 80:2924-2924
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) is an ATP-dependent DNA helicase and a catalytic component of the SWI/SNF complex. SWI/SNF-mediated nucleosome remodeling is a critical regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::377456aad17e1af658735ede3fa64551
https://doi.org/10.1158/1538-7445.am2020-2924
https://doi.org/10.1158/1538-7445.am2020-2924
Autor:
Xiang Li, Robert Hughes, Charles Kennedy, Brian Nicholas Cook, Stanley Kugler, Ingo Muegge, Delphine Collin, John Wan, Marie Anderson, Mark E. Labadia, Donna Terenzio, Neil A. Farrow, Siqi Lin, Debra L. Brennan
Publikováno v:
Journal of Biological Chemistry. 292:11618-11630
The nuclear receptor retinoid acid receptor-related orphan receptor γt (RORγt) is a master regulator of the Th17/IL-17 pathway that plays crucial roles in the pathogenesis of autoimmunity. RORγt has recently emerged as a highly promising target fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd028be21b18235969de935bcc1a90d4
https://doi.org/10.1074/jbc.m117.789024
https://doi.org/10.1074/jbc.m117.789024
Autor:
Bhamini Vaidialingam, Michael Franti, Priyanka Gupta, Neil A. Farrow, Anil Kumar Padyana, David B. Hayes
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 72:160-164
Members of the TGF-β family of proteins are believed to play critical roles in cellular signaling processes such as those involved in muscle differentiation. The extent to which individual family members have been characterized and linked to biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30406ef1dc909ef7de92344196cc591
https://doi.org/10.1107/s2053230x16001588
https://doi.org/10.1107/s2053230x16001588
Autor:
Ming-Hong Hao, E. Michael August, Danielle M. Fowler, Jin Mi Kim, Neil A. Farrow, Stéphane De Lombaert, Peter Allen Nemoto, Hidenori Takahashi, Leslie Martin, Daniel R. Albaugh, Steven S. Pullen, Kevin Chungeng Qian, Ho Yin Lo, Melissa Hill-Drzewi, Richard D. Schneiderman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4533-4539
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P1 hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene P1 moiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df6a496eb118478cab46c6fde2569f9
https://doi.org/10.1016/j.bmcl.2011.05.126
https://doi.org/10.1016/j.bmcl.2011.05.126
Autor:
Kat Cosmopoulos, Kenneth W. Duncan, Lampe John W, J. Joshua Smith, Thomas V. Riera, Neil A. Farrow, Richard Chesworth, Lei Ci, Dorothy Brach, Michael J Thomenius, Jennifer Totman, Cuyue Tang
Publikováno v:
Blood. 132:3207-3207
t(4;14) chromosome translocations are found in 15% of newly diagnosed multiple myeloma (MM) cases and are associated with high risk. MM cells with t(4;14) over-express the histone methyltransferase (HMT), WHSC1/MMSET/NSD2, which leads to deregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b4a81f7fbd2ffa0247c25750a988d1
https://doi.org/10.1182/blood-2018-99-110803
https://doi.org/10.1182/blood-2018-99-110803