Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Neil A Zakai"'
Autor:
Mary Cushman, Peter W Callas, Kristine S Alexander, Virginia Wadley, Neil A Zakai, Steven D Lidofsky, Frederick W Unverzagt, Suzanne E Judd
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0282633 (2023)
Background & aimsNonalcoholic fatty liver disease (NAFLD) is prevalent and may affect cognitive function. We studied associations of NAFLD with risk of cognitive impairment. Secondarily we evaluated liver biomarkers (alanine aminotransferase (ALT), a
Externí odkaz:
https://doaj.org/article/e5c9dd564e6a41d7bab1ac82d5a0e12f
Autor:
A Parker Ruhl, Neal Jeffries, Yu Yang, Orlando M Gutierrez, Paul Muntner, Rakhi P Naik, Lydia H Pecker, Bryan T Mott, Neil A Zakai, Monika M Safford, Leslie A Lange, Cheryl A Winkler, Marguerite R Irvin, Mary Cushman, Hans C Ackerman
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271031 (2022)
BackgroundAlpha globin is expressed in the endothelial cells of human resistance arteries where it binds to endothelial nitric oxide synthase and limits release of the vasodilator nitric oxide. Genomic deletion of the alpha globin gene (HBA) is commo
Externí odkaz:
https://doaj.org/article/54bce871f0964ea682c530e0dfd43e9d
Autor:
Cesar Higgins Tejera, Jessica Minnier, Sergio Fazio, Monika M Safford, Lisandro D. Colantonio, Marguerite R Irvin, Virginia Howard, Neil A Zakai, Nathalie Pamir
Publikováno v:
American Journal of Preventive Cardiology, Vol 7, Iss , Pp 100198- (2021)
Objective: Black adults are less likely than White adults to present with adverse lipid profiles and more likely to present with low-grade inflammation. The impact of race on the association between atherogenic lipid profiles, inflammation, and coron
Externí odkaz:
https://doaj.org/article/e88e4a83231d474a8aa3d9c68d12bab1
Autor:
Colton Leavitt, Neil A Zakai, Paul Auer, Mary Cushman, Ethan M Lange, Emily B Levitan, Nels Olson, Timothy A Thornton, Russell P Tracy, James G Wilson, Leslie A Lange, Alex P Reiner, Laura M Raffield
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231013 (2020)
Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely une
Externí odkaz:
https://doaj.org/article/5e4f3bd994644621ba2daf027309147b
Autor:
Kristine S Alexander, Neil A Zakai, Steven D Lidofsky, Peter W Callas, Suzanne E Judd, Russell P Tracy, Mary Cushman
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194153 (2018)
Liver disease, particularly non-alcoholic fatty liver disease (NAFLD), is a risk factor for cardiovascular disease, but little is known about its relationship with ischemic stroke.In the Reasons for Geographic and Racial Differences in Stroke (REGARD
Externí odkaz:
https://doaj.org/article/2e329a2c333646c28763848994498eb3
Autor:
Bashira A Charles, Matthew M Hsieh, Adebowale A Adeyemo, Daniel Shriner, Edward Ramos, Kyung Chin, Kshitij Srivastava, Neil A Zakai, Mary Cushman, Leslie A McClure, Virginia Howard, Willy A Flegel, Charles N Rotimi, Griffin P Rodgers
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194400 (2018)
BACKGROUND:Benign ethnic neutropenia (BEN) is a hematologic condition associated with people of African ancestry and specific Middle Eastern ethnic groups. Prior genetic association studies in large population showed that rs2814778 in Duffy Antigen R
Externí odkaz:
https://doaj.org/article/80cad6f1e068435ba84865d5cd3cb9ea
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102513- (2024)
Background: Ascertaining accurately the exposure to antithrombotic medications for both research and quality initiatives has been challenging due to a multitude of reasons: aspirin, the most commonly used antithrombotic, is available over the counter
Externí odkaz:
https://doaj.org/article/cde543ee658b4b89969eb7955250c8d4
Autor:
Vijaya Kancherla, Joshua V Garn, Neil A Zakai, Rebecca S Williamson, Winn T Cashion, Oluwaseun Odewole, Suzanne E Judd, Godfrey P Oakley
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160802 (2016)
Metformin, an insulin-sensitizing drug, is a first line treatment for type 2 diabetes. Long-term use of metformin has been associated with subsequent reductions in vitamin B12 concentrations. The objective of our study was to determine whether metfor
Externí odkaz:
https://doaj.org/article/c39c2867023740dfa61a8060ab5df2f5
Autor:
Michael A Nalls, David J Couper, Toshiko Tanaka, Frank J A van Rooij, Ming-Huei Chen, Albert V Smith, Daniela Toniolo, Neil A Zakai, Qiong Yang, Andreas Greinacher, Andrew R Wood, Melissa Garcia, Paolo Gasparini, Yongmei Liu, Thomas Lumley, Aaron R Folsom, Alex P Reiner, Christian Gieger, Vasiliki Lagou, Janine F Felix, Henry Völzke, Natalia A Gouskova, Alessandro Biffi, Angela Döring, Uwe Völker, Sean Chong, Kerri L Wiggins, Augusto Rendon, Abbas Dehghan, Matt Moore, Kent Taylor, James G Wilson, Guillaume Lettre, Albert Hofman, Joshua C Bis, Nicola Pirastu, Caroline S Fox, Christa Meisinger, Jennifer Sambrook, Sampath Arepalli, Matthias Nauck, Holger Prokisch, Jonathan Stephens, Nicole L Glazer, L Adrienne Cupples, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Kazuhiko Yamamoto, Naoyuki Kamatani, Michael Stumvoll, Anke Tönjes, Inga Prokopenko, Thomas Illig, Kushang V Patel, Stephen F Garner, Brigitte Kuhnel, Massimo Mangino, Ben A Oostra, Swee Lay Thein, Josef Coresh, H-Erich Wichmann, Stephan Menzel, JingPing Lin, Giorgio Pistis, André G Uitterlinden, Tim D Spector, Alexander Teumer, Gudny Eiriksdottir, Vilmundur Gudnason, Stefania Bandinelli, Timothy M Frayling, Aravinda Chakravarti, Cornelia M van Duijn, David Melzer, Willem H Ouwehand, Daniel Levy, Eric Boerwinkle, Andrew B Singleton, Dena G Hernandez, Dan L Longo, Nicole Soranzo, Jacqueline C M Witteman, Bruce M Psaty, Luigi Ferrucci, Tamara B Harris, Christopher J O'Donnell, Santhi K Ganesh
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002113 (2011)
White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability
Externí odkaz:
https://doaj.org/article/4609dc82c7f6406db499ad223bf6fcca
Autor:
Yukinori Okada, Tomomitsu Hirota, Yoichiro Kamatani, Atsushi Takahashi, Hiroko Ohmiya, Natsuhiko Kumasaka, Koichiro Higasa, Yumi Yamaguchi-Kabata, Naoya Hosono, Michael A Nalls, Ming Huei Chen, Frank J A van Rooij, Albert V Smith, Toshiko Tanaka, David J Couper, Neil A Zakai, Luigi Ferrucci, Dan L Longo, Dena G Hernandez, Jacqueline C M Witteman, Tamara B Harris, Christopher J O'Donnell, Santhi K Ganesh, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Mayumi Tamari, Kazuhiko Yamamoto, Naoyuki Kamatani
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002067 (2011)
White blood cells (WBCs) mediate immune systems and consist of various subtypes with distinct roles. Elucidation of the mechanism that regulates the counts of the WBC subtypes would provide useful insights into both the etiology of the immune system
Externí odkaz:
https://doaj.org/article/728542748e714127a681a72c203cebe7