Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Neil A J Ryan"'
Autor:
Neil A J Ryan, Raymond McMahon, Simon Tobi, Tristan Snowsill, Shona Esquibel, Andrew J Wallace, Sancha Bunstone, Naomi Bowers, Ioana E Mosneag, Sarah J Kitson, Helena O'Flynn, Neal C Ramchander, Vanitha N Sivalingam, Ian M Frayling, James Bolton, Rhona J McVey, D Gareth Evans, Emma J Crosbie
Publikováno v:
PLoS Medicine, Vol 17, Iss 9, p e1003263 (2020)
BackgroundLynch syndrome (LS) predisposes to endometrial cancer (EC), colorectal cancer, and other cancers through inherited pathogenic variants affecting mismatch-repair (MMR) genes. Diagnosing LS in women with EC can reduce subsequent cancer mortal
Externí odkaz:
https://doaj.org/article/eceb739d88234f0eb12072b08be0941f
Autor:
Tristan M Snowsill, Neil A J Ryan, Emma J Crosbie, Ian M Frayling, D Gareth Evans, Chris J Hyde
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221419 (2019)
BackgroundLynch syndrome is a hereditary cancer syndrome caused by constitutional pathogenic variants in the DNA mismatch repair (MMR) system, leading to increased risk of colorectal, endometrial and other cancers. The study aimed to identify the inc
Externí odkaz:
https://doaj.org/article/8ed4495dd89347448259211aedb7a05f
Autor:
Timothy S. Fitzsimmons, Niharika Singh, Thomas D. J. Walker, Claire Newton, Dafydd G. R. Evans, Emma J. Crosbie, Neil A. J. Ryan
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundImmune checkpoint inhibitors (ICPI) are a tumor agnostic treatment. However, trials of their use have been site specific. Here we summarize the trial data and explore the utility of programmed death-ligand 1 (PD-L1) expression as a biomarke
Externí odkaz:
https://doaj.org/article/e85e6a4434f447a39ab6c4448e66752b
Autor:
Neal C. Ramchander, Neil A. J. Ryan, Thomas D. J. Walker, Lauren Harries, James Bolton, Tjalling Bosse, D. G. Evans, Emma J. Crosbie
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Around 30% of endometrial cancers (EC) are mismatch repair (MMR) deficient, mostly as a consequence of mutations acquired during tumorigenesis, but a significant minority is caused by Lynch syndrome (LS). This inherited cancer predisposition syndrome
Externí odkaz:
https://doaj.org/article/feb8adc93b1e445eb2b31f037913d8d9
Autor:
Neil A. J. Ryan, Dominic Blake, Marcus Cabrera-Dandy, Mark A. Glaire, D. Gareth Evans, Emma J. Crosbie
Publikováno v:
Systematic Reviews, Vol 7, Iss 1, Pp 1-6 (2018)
Abstract Background Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer. The early diagnosis of Lynch syndrome enables colorectal s
Externí odkaz:
https://doaj.org/article/00952b47c829455182c56b630ba5a081
Autor:
Neil A. J. Ryan, Niall J. Davison, Katherine Payne, Anne Cole, D. Gareth Evans, Emma J. Crosbie
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Lynch syndrome is the most common inherited cause of endometrial cancer. Identifying individuals affected by Lynch syndrome enables risk-reducing interventions including colorectal surveillance, and cascade testing of relatives.Methods: W
Externí odkaz:
https://doaj.org/article/8b1deb1ad9d047af9e4c62084663c7af
Autor:
Amit Atwal, Tristan Snowsill, Marcus Cabrera Dandy, Thomas Krum, Claire Newton, Dafydd Gareth Evans, Emma J. Crosbie, Neil A. J. Ryan
Publikováno v:
Atwal, A, Snowsill, T, Dandy, M C, Krum, T, Newton, C, Evans, D G, Crosbie, E J & Ryan, N A J 2022, ' The prevalence of mismatch repair deficiency in ovarian cancer: A systematic review and meta-analysis ', International Journal of Cancer, vol. 151, no. 9, pp. 1626-1639 . https://doi.org/10.1002/ijc.34165
Atwal, A, Snowsill, T, Dandy, M C, Krum, T, Newton, C, Evans, D G, Crosbie, E J & Ryan, N A J 2022, ' The prevalence of mismatch repair deficiency in ovarian cancer : A systematic review and meta-analysis ', International Journal of Cancer, vol. 151, no. 9, pp. 1626-1639 . https://doi.org/10.1002/ijc.34165
Atwal, A, Snowsill, T, Dandy, M C, Krum, T, Newton, C, Evans, D G, Crosbie, E J & Ryan, N A J 2022, ' The prevalence of mismatch repair deficiency in ovarian cancer : A systematic review and meta-analysis ', International Journal of Cancer, vol. 151, no. 9, pp. 1626-1639 . https://doi.org/10.1002/ijc.34165
Ovarian cancer (OC) is the least survivable gynecological malignancy and presents late. Five-year survival for OC is around 45% increasing the need for innovative treatments. Checkpoint inhibitors have shown significant clinical efficacy in mismatch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4482f2e498af8d53e3dcb45a79ff52
https://hdl.handle.net/20.500.11820/11815da0-ddbe-42e5-b900-3394ed7cfd65
https://hdl.handle.net/20.500.11820/11815da0-ddbe-42e5-b900-3394ed7cfd65
Autor:
Rhona J McVey, Y Louise Wan, Akheel A. Syed, Michelle L. MacKintosh, Chloe E Barr, Neil A J Ryan, James Bolton, Richard J Slade, Dina Awad, Abigail E. Derbyshire, Cheryl T. Fitzgerald, Basil J. Ammori, Emma J Crosbie
Publikováno v:
Cancer Prevention Research. 14:1041-1050
Intrauterine progestin is a treatment option for women with atypical hyperplasia or low-risk endometrial cancer who wish to preserve their fertility, or whose poor surgical fitness precludes safe hysterectomy. We hypothesized that in such women with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a787bfa56743e7db94ea7e8f2c6733e6
https://doi.org/10.1158/1940-6207.capr-21-0229
https://doi.org/10.1158/1940-6207.capr-21-0229
Autor:
Mourad W. Seif, Neil A J Ryan, Neal C Ramchander, Raymond Mcmahon, Emma J Crosbie, D. Gareth Evans
Publikováno v:
The Obstetrician & Gynaecologist
Ryan, N, McMahon, R, Ramchander, N, Seif, M W, Evans, D G & Crosbie, E 2020, ' Lynch syndrome for the gynaecologist ', The Obstetrician and Gynaecologist . https://doi.org/10.1111/tog.12706
Ryan, N, McMahon, R, Ramchander, N, Seif, M W, Evans, D G & Crosbie, E 2020, ' Lynch syndrome for the gynaecologist ', The Obstetrician and Gynaecologist . https://doi.org/10.1111/tog.12706
Key content Lynch syndrome is an autosomal dominant condition closely associated with colorectal, endometrial and ovarian cancer.Women with Lynch syndrome are at increased risk of both endometrial and ovarian cancer and should be offered personalised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d4ba0c87677a1406c6d71f1a7d36d5
https://doi.org/10.1111/tog.12706
https://doi.org/10.1111/tog.12706
Autor:
Neil A J Ryan, Helena O'Flynn, Nadira Narine, Dina Awad, Durgesh Rana, David Shelton, Emma J Crosbie, Eleanor R Jones
Publikováno v:
Narine, N, Rana, D, Shelton, D, Awad, D, O'Flynn, H, Jones, E R, Ryan, N & Crosbie, E 2022, ' Synchronous uterine and bladder cancers detected in urine and vaginal samples by cytology ', Diagnostic Cytopathology . https://doi.org/10.1002/dc.24906
Novel diagnostics for uterine cancer are urgently needed to reduce the burden of invasive testing for the majority of healthy women with postmenopausal bleeding. We have previously shown that uterine cancer cells can be detected by cytology in urine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969a3e471fb478e03fc48bf223d45e0c
https://pubmed.ncbi.nlm.nih.gov/34783454
https://pubmed.ncbi.nlm.nih.gov/34783454