Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Neil Brockdorff"'
Autor:
Joseph S. Bowness, Tatyana B. Nesterova, Guifeng Wei, Lisa Rodermund, Mafalda Almeida, Heather Coker, Emma J. Carter, Artun Kadaster, Neil Brockdorff
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110830- (2022)
Summary: X chromosome inactivation (XCI) is mediated by the non-coding RNA Xist, which directs chromatin modification and gene silencing in cis. The RNA binding protein SPEN and associated corepressors have a central role in Xist-mediated gene silenc
Externí odkaz:
https://doaj.org/article/cbb4ebeca8874aee9b97248ef77766d9
Autor:
Tatyana B. Nesterova, Guifeng Wei, Heather Coker, Greta Pintacuda, Joseph S. Bowness, Tianyi Zhang, Mafalda Almeida, Bianca Bloechl, Benoit Moindrot, Emma J. Carter, Ines Alvarez Rodrigo, Qi Pan, Ying Bi, Chun-Xiao Song, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Xist RNA is the master regulator of X chromosome inactivation. Here the authors describe a systematic analysis of Xist-mediated allelic silencing in mouse ESC models and define the contribution of different pathways that regulate gene silencing.
Externí odkaz:
https://doaj.org/article/1099fcaec9864035a2a87b2701f1ba55
Autor:
Michal R. Gdula, Tatyana B. Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M. Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The inactive X chromosome (Xi) has an atypical structure, with global loss of TADs, A/B compartments and formation of mega-domains. Here the authors show that the non-canonical SMC family protein, SmcHD1, important for developmental gene silencing on
Externí odkaz:
https://doaj.org/article/9651dc44fd574c31817692a66b9637db
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101741- (2020)
Summary: Transcriptional fidelity depends on accurate promoter selection and initiation from the correct sites. In yeast, H3K36me3-mediated recruitment of the Rpd3S HDAC complex to gene bodies suppresses spurious transcription initiation. Here we des
Externí odkaz:
https://doaj.org/article/a018d1b1e063427d8727a4e6c17a474f
Autor:
Heather Coker, Guifeng Wei, Benoit Moindrot, Shabaz Mohammed, Tatyana Nesterova, Neil Brockdorff
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background: X chromosome inactivation in mammals is regulated by the non-coding (nc) RNA, Xist, which represses the chromosome from which it is transcribed. High levels of the N6-methyladenosine (m6A) RNA modification occur within Xist exon I, close
Externí odkaz:
https://doaj.org/article/b298b9adf43348348402ac34948230ba
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Autor:
Tianyi Zhang, Guifeng Wei, Christopher J. Millard, Roman Fischer, Rebecca Konietzny, Benedikt M. Kessler, John W. R. Schwabe, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transcription regulation requires recruitment of different epigenetic regulators to the chromatin. Here the authors provide evidence that an H3K36me3 reader PWWP2A forms a variant NuRD complex and plays a role in regulating transcription and histone
Externí odkaz:
https://doaj.org/article/5054f4fdda3244658206c728b04b321a
Autor:
Neil Brockdorff
Publikováno v:
Open Biology, Vol 9, Iss 12 (2019)
The non-coding RNA Xist regulates the process of X chromosome inactivation, in which one of the two X chromosomes present in cells of early female mammalian embryos is selectively and coordinately shut down. Remarkably Xist RNA functions in cis, affe
Externí odkaz:
https://doaj.org/article/b92e267e91c94ef99ed243d2fa40aa79
Autor:
Sarah Cooper, Anne Grijzenhout, Elizabeth Underwood, Katia Ancelin, Tianyi Zhang, Tatyana B. Nesterova, Burcu Anil-Kirmizitas, Andrew Bassett, Susanne M. Kooistra, Karl Agger, Kristian Helin, Edith Heard, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental regulation of the genome in multicellular organisms. Here the authors describe how the PRC2 cofactor Jarid2 mediates the recruitment of the PRC2 complex to chromatin
Externí odkaz:
https://doaj.org/article/b92aed92ccad489c830eec2852858b92
Autor:
Irene Cantone, Hakan Bagci, Dirk Dormann, Gopuraja Dharmalingam, Tatyana Nesterova, Neil Brockdorff, Claire Rougeulle, Celine Vallot, Edith Heard, Ronan Chaligne, Matthias Merkenschlager, Amanda G. Fisher
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Reactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that
Externí odkaz:
https://doaj.org/article/4e0f58511c414c589feb938c38b79712
Autor:
Bryony Graham, Antoine Marcais, Gopuraja Dharmalingam, Thomas Carroll, Chryssa Kanellopoulou, Johannes Graumann, Tatyana B. Nesterova, Anna Bermange, Pijus Brazauskas, Barbara Xella, Skirmantas Kriaucionis, Douglas R. Higgs, Neil Brockdorff, Matthias Mann, Amanda G. Fisher, Matthias Merkenschlager
Publikováno v:
Stem Cell Reports, Vol 6, Iss 5, Pp 635-642 (2016)
Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediated repressive (H3K27me3) histone modifications. This bivalent state is thought to be important for trans
Externí odkaz:
https://doaj.org/article/a6b3d9828f3543e685cd94c0e184dd85