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Impact of antithrombin III and enoxaparin dosage adjustment on prophylactic anti-Xa concentrations in trauma patients at high risk for venous thromboembolism: a randomized pilot trial

Autor: Megan Webb, Devin Wakefield, Carolyn Philpott, Krishna Athota, Bryce H R Robinson, Molly E. Droege, Christopher A. Droege, Dennis J. Hanseman, Joel Elterman, Eric W. Mueller, Dina Gomaa, Joseph Richard Dowd, Neil Ernst

Publikováno v: Journal of Thrombosis and Thrombolysis. 52:1117-1128

The impact of antithrombin III activity (AT-III) on prophylactic enoxaparin anti-factor Xa concentration (anti-Xa) is unknown in high-risk trauma patients. So too is the optimal anti-Xa-adjusted enoxaparin dosage. This prospective, randomized, pilot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36889cf1e87a68156d70579b72eb42a
https://doi.org/10.1007/s11239-021-02478-4

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Admission thrombelastography does not guide dose adjustment of enoxaparin in trauma patients

Autor: Christopher A. Droege, Craig Furnish, Molly E. Droege, Michael D. Goodman, Hannah V. Hayes, Neil Ernst

Publikováno v: Surgery Open Science, Vol 2, Iss 4, Pp 41-44 (2020)
Surgery Open Science

Background Enoxaparin is used as chemoprophylaxis to reduce incidence of venous thromboembolism and its complications following trauma. Serum anti-Xa monitoring is used to assess efficacy but requires several doses to be administered. Thrombelastogra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8c6f2cb0b747ce5c62ac30936b84bf
http://www.sciencedirect.com/science/article/pii/S2589845020300099

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Assessment of Detectable Serum Tobramycin Concentrations in Patients Receiving Inhaled Tobramycin for Ventilator-Associated Pneumonia

Autor: Betty J. Tsuei, Eric W. Mueller, Madeline Foertsch, Neil Ernst, Andrew E Globke, Christopher A. Droege, Paige Bradshaw, Dina Gomaa

Publikováno v: Respiratory care.

BACKGROUND: Inhaled tobramycin can be used for empiric or definitive therapy of ventilator-associated pneumonia (VAP) in mechanically ventilated patients. This is believed to minimize systemic exposure and potential adverse drug toxicities including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e69d3084d3e928c8f8dc2b7696781f
https://pubmed.ncbi.nlm.nih.gov/34815325

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Clinical Experience, Characteristics, and Performance of an Acetaminophen Absorption Test in Critically Ill Patients

Autor: Molly E. Droege, Eric W. Mueller, Daniel R Mosher, Aaron M Swomley, Abigail G Rhoades, Christopher A. Droege, Neil Ernst

Publikováno v: American journal of therapeutics.

BACKGROUND Altered drug and nutrient absorption presents a unique challenge in critically ill patients. Performing an acetaminophen absorption test (AAT) has been used as a marker for gastric motility and upper small bowel absorption; thus, it may pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213cafd6bbfa17e0f8bd119b7aca18e6
https://pubmed.ncbi.nlm.nih.gov/34387562

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Cefepime Population Pharmacokinetics and Target Attainment in Critically Ill Patients on Continuous Renal Replacement Therapy

Autor: Joshua D Courter, Carolyn Philpott, Charles A. Peloquin, Molly E. Droege, Mohammad H. Al-Shaer, Eric W. Mueller, Daniel P. Healy, Neil Ernst, Christopher A. Droege

Publikováno v: Antimicrob Agents Chemother

Sepsis causes half of acute kidney injuries in the intensive care unit (ICU). ICU patients may need continuous renal replacement therapy (CRRT), which will affect their antimicrobial exposure. We aimed to build a cefepime population pharmacokinetic (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afd8c00884dec25f768a9561c4752e5
https://europepmc.org/articles/PMC8316051/

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Impact of Weight on Anti-Xa Attainment in High-Risk Trauma Patients on Enoxaparin Chemoprophylaxis

Autor: Christopher A. Droege, Molly E. Droege, Neil Ernst, Eric W. Mueller, Kaley Marie Deichstetter, Carolyn Philpott, Julie Elizabeth Farrar, Amy T. Makley

Publikováno v: The Journal of surgical research. 264

Serum anti-factor Xa (anti-Xa) concentration may guide low molecular weight heparin chemoprophylaxis in trauma patients. Higher total body weight (TBW) is a risk factor for subprophylactic anti-Xa and venous thromboembolism (VTE). The purpose of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e2fec407b9d7b2c6fcf8c2d6bb5268
https://pubmed.ncbi.nlm.nih.gov/33848842

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