Coupled climate-carbon simulations of the Penultimate Deglaciation and Last Interglacial in the PLASIM-GENIE model

Autor: Tim Cutler, Philip Holden, Pallavi Anand, Neil Edwards

Theoretical understanding of paleoclimate change such as deglaciations comes primarily from time slice simulations in state-of-the-art atmosphere-ocean general circulation models, where multimillennial transient simulations would be too computational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ebffd66ef60c465773824b5facb4124
https://doi.org/10.5194/egusphere-egu23-8172

Beyond the Barrier: Communication in the Root through the Endodermis

Autor: Lina Duan, José R. Dinneny, Charlotte Trontin, Neil Edwards Robbins

Publikováno v: PLANT PHYSIOLOGY. 166:551-559

The root endodermis is characterized by the Casparian strip and by the suberin lamellae, two hydrophobic barriers that restrict the free diffusion of molecules between the inner cell layers of the root and the outer environment. The presence of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36ae78f5e2637c0a2778a55b2a5dfe63
https://doi.org/10.1104/pp.114.244871

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Autor: Alberto C.C. Frasch, Michael H. Charlton, Paul N. Mortenson, Richard A. Bryce, Horacio Botti, Mark L. Brewer, Pedro M. Alzari, Alejandro Buschiazzo, João Neres, Kenneth T. Douglas, Laura Ratier, Philip Neil Edwards

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2009, 19 (3), pp.589-596. ⟨10.1016/j.bmcl.2008.12.065⟩
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (3), pp.589-596. ⟨10.1016/j.bmcl.2008.12.065⟩

International audience; trans-Sialidase from Trypanosoma cruzi (TcTS) has emerged as a potential drug target for treatment of Chagas disease. Here, we report the results of virtual screening for the discovery of novel TcTS inhibitors, which targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d3df2ee80c2f17123994ec9e40de52
https://doi.org/10.1016/j.bmcl.2008.12.065

Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Recruitment and assessment methods

Autor: Muktar H, Aliyu, Monica E, Calkins, Charlie L, Swanson, Paul D, Lyons, Robert M, Savage, Roberta, May, Howard, Wiener, Stephen, McLeod-Bryant, Bernie, Devlin, Vishwajit L, Nimgaonkar, J Daniel, Ragland, Raquel E, Gur, Ruben C, Gur, L Dianne, Bradford, Neil, Edwards, Joseph, Kwentus, Joseph P, McEvoy, Alberto B, Santos, Stephen, McCleod-Bryant, Clifton, Tennison, Rodney C P, Go, Trina B, Allen

Publikováno v: Schizophrenia Research. 87:32-44

The Project among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) is a multi-site, NIMH-funded study that seeks to identify genetic polymorphisms that confer susceptibility to schizophrenia among African-Americans by linkage mapping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1c75d1c581febaf924a0b99212df74
https://doi.org/10.1016/j.schres.2006.06.027

Synthesis of (±)-Anatoxin-a and Analogues

Autor: Neil Edwards, L. Ravi Sumoreeah, Nicholas P. Camp, Philip J. Parsons

Publikováno v: Tetrahedron. 56:309-315

A new and highly efficient synthesis of the potent nicotinic acetylcholine receptor agonist, anatoxin-a and its analogues is described, which uses a s-lactam ring opening-transannular cyclisation sequence to set up the bridged bicyclic framework of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e77036863ba8e5aefa24c7b8b8c1e0c8
https://doi.org/10.1016/s0040-4020(99)00909-6