Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Neil, E Fleshner"'
Autor:
Jethro C C Kwong, MD, Adree Khondker, BHSc, Eric Meng, BSc, Nicholas Taylor, BSc, Cynthia Kuk, MSc, Nathan Perlis, MD, Girish S Kulkarni, ProfMD, Robert J Hamilton, MD, Neil E Fleshner, ProfMD, Antonio Finelli, ProfMD, Theodorus H van der Kwast, ProfMD, Amna Ali, BSc, Munir Jamal, MD, Frank Papanikolaou, MD, Thomas Short, MD, John R Srigley, ProfMD, Valentin Colinet, MD, Alexandre Peltier, ProfMD, Romain Diamand, MD, Yolene Lefebvre, MD, Qusay Mandoorah, MD, Rafael Sanchez-Salas, MD, Petr Macek, MD, Xavier Cathelineau, ProfMD, Martin Eklund, ProfPhD, Alistair E W Johnson, DPhil, Andrew Feifer, MD, Alexandre R Zlotta, ProfMD
Publikováno v:
The Lancet: Digital Health, Vol 5, Iss 7, Pp e435-e445 (2023)
Summary: Background: Accurate prediction of side-specific extraprostatic extension (ssEPE) is essential for performing nerve-sparing surgery to mitigate treatment-related side-effects such as impotence and incontinence in patients with localised pros
Externí odkaz:
https://doaj.org/article/9e48ab8efa664112a1f3da359fa83dba
Autor:
Neil E. Fleshner, Shabbir M. H. Alibhai, Kim A. Connelly, Ilidio Martins, Bernhard J. Eigl, Himu Lukka, Armen Aprikian
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Orally administrated agents play a key role in the management of prostate cancer, providing a convenient and cost-effective treatment option for patients. However, they are also associated with adherence issues which can compromise therap
Externí odkaz:
https://doaj.org/article/e142286d478b4810b1800c8de4573e50
Autor:
Esmail M. Al‐Ezzi, Husam A. Alqaisi, Marco A. J. Iafolla, Lisa Wang, Srikala S. Sridhar, Adrian G. Sacher, Nazanin Fallah‐Rad, Di M. Jiang, Geoffrey A. Watson, Charles N. Catton, Padraig R. Warde, Rob J. Hamilton, Neil E. Fleshner, Alexandre R. Zlotta, Aaron R. Hansen
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 5775-5782 (2021)
Abstract Background In men with metastatic castration‐resistant prostate cancer (mCRPC) with primarily bone metastases, radium‐223 (223Ra) improves overall survival (OS). However, the selection of 223Ra is not guided by specific validated clinico
Externí odkaz:
https://doaj.org/article/da392819a41c4b0387329a1e9a5afd5b
Autor:
Madonna R. Peter, Misha Bilenky, Alastair Davies, Ruth Isserlin, Gary D. Bader, Neil E. Fleshner, Martin Hirst, Amina Zoubeidi, Bharati Bapat
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Androgens are a major driver of prostate cancer (PCa) and continue to be a critical treatment target for advanced disease, which includes castration therapy and antiandrogens. However, resistance to these therapies leading to metastatic cast
Externí odkaz:
https://doaj.org/article/8a0d4c3f1dab4fb8aab66b888d10d9ef
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, i
Externí odkaz:
https://doaj.org/article/659563073c8047df8fbe62528b353b71
Autor:
Yu Jiang, Travis J. Meyers, Adaeze A. Emeka, Lauren Folgosa Cooley, Phillip R. Cooper, Nicola Lancki, Irene Helenowski, Linda Kachuri, Daniel W. Lin, Janet L. Stanford, Lisa F. Newcomb, Suzanne Kolb, Antonio Finelli, Neil E. Fleshner, Maria Komisarenko, James A. Eastham, Behfar Ehdaie, Nicole Benfante, Christopher J. Logothetis, Justin R. Gregg, Cherie A. Perez, Sergio Garza, Jeri Kim, Leonard S. Marks, Merdie Delfin, Danielle Barsa, Danny Vesprini, Laurence H. Klotz, Andrew Loblaw, Alexandre Mamedov, S. Larry Goldenberg, Celestia S. Higano, Maria Spillane, Eugenia Wu, H. Ballentine Carter, Christian P. Pavlovich, Mufaddal Mamawala, Tricia Landis, Peter R. Carroll, June M. Chan, Matthew R. Cooperberg, Janet E. Cowan, Todd M. Morgan, Javed Siddiqui, Rabia Martin, Eric A. Klein, Karen Brittain, Paige Gotwald, Daniel A. Barocas, Jeremiah R. Dallmer, Jennifer B. Gordetsky, Pam Steele, Shilajit D. Kundu, Jazmine Stockdale, Monique J. Roobol, Lionne D.F. Venderbos, Martin G. Sanda, Rebecca Arnold, Dattatraya Patil, Christopher P. Evans, Marc A. Dall’Era, Anjali Vij, Anthony J. Costello, Ken Chow, Niall M. Corcoran, Soroush Rais-Bahrami, Courtney Phares, Douglas S. Scherr, Thomas Flynn, R. Jeffrey Karnes, Michael Koch, Courtney Rose Dhondt, Joel B. Nelson, Dawn McBride, Michael S. Cookson, Kelly L. Stratton, Stephen Farriester, Erin Hemken, Walter M. Stadler, Tuula Pera, Deimante Banionyte, Fernando J. Bianco, Jr., Isabel H. Lopez, Stacy Loeb, Samir S. Taneja, Nataliya Byrne, Christopher L. Amling, Ann Martinez, Luc Boileau, Franklin D. Gaylis, Jacqueline Petkewicz, Nicholas Kirwen, Brian T. Helfand, Jianfeng Xu, Denise M. Scholtens, William J. Catalona, John S. Witte
Publikováno v:
HGG Advances, Vol 3, Iss 1, Pp 100070- (2022)
Summary: Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for PC, many men on AS eventually convert to active
Externí odkaz:
https://doaj.org/article/dd671a3166f5492e9f3db2429cd59265
Autor:
Madonna R. Peter, Fang Zhao, Renu Jeyapala, Shivani Kamdar, Wei Xu, Cynthia Hawkins, Andrew J. Evans, Neil E. Fleshner, Antonio Finelli, Bharati Bapat
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Renal cell carcinomas (RCC) are usually asymptomatic until late stages, posing several challenges for early detection of malignant disease. Non-invasive liquid biopsy biomarkers are emerging as an important diagnostic tool which could aid with routin
Externí odkaz:
https://doaj.org/article/08d6e032ca5f4a4db67891b77eddf343
Autor:
Alexandre R Zlotta, Leslie K Ballas, Andrzej Niemierko, Katherine Lajkosz, Cynthia Kuk, Gus Miranda, Michael Drumm, Andrea Mari, Ethan Thio, Neil E Fleshner, Girish S Kulkarni, Michael A S Jewett, Robert G Bristow, Charles Catton, Alejandro Berlin, Srikala S Sridhar, Anne Schuckman, Adam S Feldman, Matthew Wszolek, Douglas M Dahl, Richard J Lee, Philip J Saylor, M Dror Michaelson, David T Miyamoto, Anthony Zietman, William Shipley, Peter Chung, Siamak Daneshmand, Jason A Efstathiou
Publikováno v:
The Lancet Oncology. 24:669-681
Autor:
Joseph Longo, Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Mehdi Masoomian, Dixon T.S. Woon, Yuzhuo Wang, Eric X. Chen, Robert J. Hamilton, Joan M. Sweet, Theodorus H. van der Kwast, Neil E. Fleshner, Linda Z. Penn
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 119-130 (2019)
Objective: The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that statin
Externí odkaz:
https://doaj.org/article/f03d8eaff63e4e4990bc23cc62eb3734
Autor:
Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner, Bharati Bapat
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-19 (2019)
Abstract Background Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifically targeted by androg
Externí odkaz:
https://doaj.org/article/e6d4dc82c3a047528c0b7b4c702f08f0