Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nehmé El-Hachem"'
Autor:
Athar Khalil, Rachel Tanos, Nehmé El-Hachem, Mazen Kurban, Patrice Bouvagnet, Fadi Bitar, Georges Nemer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Congenital heart disease is the leading cause of death in the first year of life. Mutations only in few genes have been linked to some cases of CHD. Thalidomide was used by pregnant women for morning sickness but was removed from the market
Externí odkaz:
https://doaj.org/article/159fba6c65b64a8ab565eb39390cea36
Autor:
Jean Pierre Bikorimana, Nehme El-Hachem, Jamilah Abusarah, Marina Pereira Gonçalves, Roudy Farah, Gabrielle A. Mandl, Sebastien Talbot, Simon Beaudoin, Daniela Stanga, Sebastien Plouffe, Moutih Rafei
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background The Accum® platform was initially designed to accumulate biomedicines in target cells by inducing endosomal-to-cytosol escape. Interestingly however, the use of unconjugated Accum® was observed to trigger cell death in a variety
Externí odkaz:
https://doaj.org/article/7d2f9cdb541d4c5a89829e139a5119e2
Autor:
Marina Pereira Gonçalves, Roudy Farah, Jean-Pierre Bikorimana, Jamilah Abusarah, Nehme EL-Hachem, Wael Saad, Sebastien Talbot, Daniela Stanga, Simon Beaudoin, Sebastien Plouffe, Moutih Rafei
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109248- (2024)
Summary: Mesenchymal stromal cells (MSCs) have been modified via genetic or pharmacological engineering into potent antigen-presenting cells-like capable of priming responding CD8 T cells. In this study, our screening of a variant library of Accum mo
Externí odkaz:
https://doaj.org/article/e7f19ff8e92643ef933a5d7182a252ff
Autor:
Natasha Salame, Jean-Pierre Bikorimana, Nehme El-Hachem, Wael Saad, Mazen Kurdi, Jing Zhao, Nicoletta Eliopoulos, Riam Shammaa, Moutih Rafei
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background Mesenchymal stromal cells (MSCs) have been extensively used in the clinic due to their exquisite tissue repair capacity. However, they also hold promise in the field of cellular vaccination as they can behave as conditional antige
Externí odkaz:
https://doaj.org/article/fffee480623141a1968e76cc81908d9e
Autor:
Jean-Pierre Bikorimana, Nehme El-Hachem, Jamilah Abusarah, Nicoletta Eliopoulos, Sebastien Talbot, Riam Shammaa, Moutih Rafei
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105537- (2022)
Summary: Immunoproteasome-reprogrammed mesenchymal stromal cells (IRMs) can surpass dendritic cells at eliciting tumor-specific immunity. However, the current IRM vaccination regimen remains clinically unsuitable due to the relatively high dose of IR
Externí odkaz:
https://doaj.org/article/ca5732deff804308b5e2a158b4707052
Autor:
Natasha Salame, Katharine Fooks, Nehme El-Hachem, Jean-Pierre Bikorimana, François E. Mercier, Moutih Rafei
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Multi-omic approaches offer an unprecedented overview of the development, plasticity, and resistance of cancer. However, the translation from anti-cancer compounds identified in vitro to clinically active drugs have a notoriously low success rate. He
Externí odkaz:
https://doaj.org/article/48f3ff363b204134be5ee8b737670d67
Autor:
Abeer J. Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A. El-Achkar, Sandra E. Ghayad, Oula K. Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem, Eva Hamade, Aida Habib
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-18 (2019)
Abstract Introduction New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages. Methods The synthesis of the designed molecules started from easily accessible and versa
Externí odkaz:
https://doaj.org/article/84a342bf0b0e458f804a0b73c9bae9a6
Autor:
Fatemeh Mardani, Wael Saad, Nehme El-Hachem, Jean-Pierre Bikorimana, Mazen Kurdi, Riam Shammaa, Sebastien Talbot, Moutih Rafei
Publikováno v:
Cells, Vol 11, Iss 11, p 1816 (2022)
Mesenchymal stromal cells (MSCs) are commonly known for their immune-suppressive abilities. However, our group provided evidence that it is possible to convert MSCs into potent antigen presenting cells (APCs) using either genetic engineering or pharm
Externí odkaz:
https://doaj.org/article/6de7ed82c2a94f1f992e47fd6cd2cf50
Autor:
Jean-Pierre Bikorimana, Nehme El-Hachem, Abed El-Hakim El-Kadiry, Jamilah Abusarah, Natasha Salame, Riam Shammaa, Moutih Rafei
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Proteasomes are complex macromolecular structures existing in various forms to regulate a myriad of cellular processes. Besides degrading unwanted or misfolded proteins (proteostasis), distinct immune functions were ascribed for the immunoproteasome
Externí odkaz:
https://doaj.org/article/f4d828782fb14de99c62027afc06ac14
Autor:
Nehme El-Hachem, Edward Eid, Georges Nemer, Ghassan Dbaibo, Ossama Abbas, Nelly Rubeiz, Salah Zeineldine, Ghassan M. Matar, Jean-Pierre Bikorimana, Riam Shammaa, Benjamin Haibe-Kains, Mazen Kurban, Moutih Rafei
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101697- (2020)
Summary: The beginning of the 21st century has been marked by three distinct waves of zoonotic coronavirus outbreaks into the human population. The COVID-19 (coronavirus disease 2019) pandemic is caused by severe acute respiratory syndrome coronaviru
Externí odkaz:
https://doaj.org/article/dd115cc6c1074b86bc6aa8ed197296e1