Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nehmé, Saksouk"'
Autor:
Sébastien Calvet, Séphora Sallis, Nehmé Saksouk, Cosette Rebouissou, Catherine Teyssier, Annick Lesne, Florence Cammas, Thierry Forné
Publikováno v:
Cells, Vol 11, Iss 15, p 2392 (2022)
About half of the mammalian genome is constituted of repeated elements, among which endogenous retroviruses (ERVs) are known to influence gene expression and cancer development. The HP1 (Heterochromatin Protein 1) proteins are known to be essential f
Externí odkaz:
https://doaj.org/article/20bc96c941dd4f52aee07a8ac7ba44be
Autor:
Marine Pratlong, Eric Fabbrizio, Lakdhar Khellaf, Nelly Pirot, Amélie Sarrazin, Damien Grégoire, Yannick Perez, Shefqet Hajdari, Jean-Yohan Noël, Eric Julien, Nehmé Saksouk, Aliki Zavoriti, Florence Cammas, Céline Graber, Célia Barrachina
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2020, 39 (13), pp.2676-2691. ⟨10.1038/s41388-020-1177-8⟩
Oncogene, Nature Publishing Group, 2020, 39 (13), pp.2676-2691. ⟨10.1038/s41388-020-1177-8⟩
International audience; Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin associated proteins HP1 are dispensable for hepatocytes survival but are essential within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261f982476fcd05a475d58373edb93fb
https://doi.org/10.1038/s41388-020-1177-8
https://doi.org/10.1038/s41388-020-1177-8
Autor:
Nehmé, Saksouk, Shefqet, Hajdari, Yannick, Perez, Marine, Pratlong, Célia, Barrachina, Céline, Graber, Damien, Grégoire, Aliki, Zavoriti, Amélie, Sarrazin, Nelly, Pirot, Jean-Yohan, Noël, Lakhdar, Khellaf, Eric, Fabbrizio, Eric, Julien, Florence M, Cammas
Publikováno v:
Oncogene. 39(13)
Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin-associated proteins HP1 are dispensable for hepatocytes survival but are essential within hepatocytes to prevent l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d590e9afe6a5505ad43994bd91171c4
https://pubmed.ncbi.nlm.nih.gov/32020053
https://pubmed.ncbi.nlm.nih.gov/32020053
Autor:
Leonie I. Kroeze, Michiel Vermeulen, Jérôme Déjardin, Arie B. Brinkman, Guido van Mierlo, Michelle Huth, Laura De Clerck, René A.M. Dirks, Dieter Deforce, Nehmé Saksouk, Hendrik Marks, Joop H. Jansen, Christoph Bock, Matthias Farlik, Maarten Dhaenens, Sander Willems, Susan L. Kloet
Publikováno v:
Cell Stem Cell, 24(1), 123-+. CELL PRESS
Cell Stem Cell, 24, 1, pp. 123-137, e1-e8
Cell Stem Cell
Cell Stem Cell, 24, 123-137, e1-e8
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 24 (1), pp.123-137.e8. ⟨10.1016/j.stem.2018.10.017⟩
Cell Stem Cell, 24(1), 123-137.e8
Cell Stem Cell 24 (2019) 1
Cell Stem Cell, 24, 1, pp. 123-137, e1-e8
Cell Stem Cell
Cell Stem Cell, 24, 123-137, e1-e8
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 24 (1), pp.123-137.e8. ⟨10.1016/j.stem.2018.10.017⟩
Cell Stem Cell, 24(1), 123-137.e8
Cell Stem Cell 24 (2019) 1
International audience; The pluripotent ground state is defined as a basal state free of epigenetic restrictions, which influence lineage specification. While naive embryonic stem cells (ESCs) can be maintained in a hypomethylated state with open chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56696ad11be86f27996d784776cfee6b
http://hdl.handle.net/1887/122267
http://hdl.handle.net/1887/122267
Autor:
Nehmé Saksouk, Raymund J. Wellinger, Axel Imhof, Mathilde Gauchier, Reini F. Luco, Satoru Ide, Sandrine Sauzet, Serge Urbach, Sophie Kan, Jérôme Déjardin, Amandine Barral, Erin Bonnell, Teresa K. Barth, Eneritz Agirre
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2019, 5 (5), pp.eaav3673. ⟨10.1126/sciadv.aav3673⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2019, 5 (5), pp.eaav3673. ⟨10.1126/sciadv.aav3673⟩
Atypical heterochromatin forms on telomeres and correlates with ALT activities.
Alternative lengthening of telomeres, or ALT, is a recombination-based process that maintains telomeres to render some cancer cells immortal. The prevailing view is
Alternative lengthening of telomeres, or ALT, is a recombination-based process that maintains telomeres to render some cancer cells immortal. The prevailing view is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7dd25b516bf5621893b51f1166b388b
Autor:
Jean-Yohan Noël, Aliki Zavoriti, Amélie Sarrazin, Shefqet Hajdari, Céline Graber, Eric Julien, Eric Fabbrizio, Célia Barrachina, Nelly Pirot, Nehmé Saksouk, Lakhdar Khellaf, Marine Pratlong, Florence Cammas
Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin associated proteins HP1 are dispensable for cell survival but are essential within hepatocytes to prevent liver tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853c5a4cb59991f773a9c94266371e52
https://doi.org/10.1101/441279
https://doi.org/10.1101/441279
Publikováno v:
Methods in Molecular Biology ISBN: 9781493967452
The biological functions of given genomic regions are ruled by the local chromatin composition. The Proteomics of Isolated Chromatin segments approach (PICh) is a powerful and unbiased method to analyze the composition of chosen chromatin segments, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3836bd4a53a68b1298149e74418ea0e
https://doi.org/10.1007/978-1-4939-6747-6_3
https://doi.org/10.1007/978-1-4939-6747-6_3
Autor:
Nehmé Saksouk, Song Tan, Marie-Eve Lalonde, Brianna J. Klein, Jacques Côté, Tatiana G. Kutateladze, Xiang-Jiao Yang, Nikita Avvakumov, Michael J. Holliday, Eric Paquet, Kezhi Yan, Karen C. Glass, France-Hélène Joncas, Qiong Tong
Publikováno v:
Genes & Development. 27:2009-2024
Histone acetyltransferases (HATs) assemble into multisubunit complexes in order to target distinct lysine residues on nucleosomal histones. Here, we characterize native HAT complexes assembled by the BRPF family of scaffold proteins. Their plant home
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a02eabb539a20f0a9f5f4eeb25bf73
https://doi.org/10.1101/gad.223396.113
https://doi.org/10.1101/gad.223396.113
Autor:
Steeve Provencher, Eric Dumas de la Roque, Roxane Paulin, Mark A. Sussman, Jolyane Meloche, Nehmé Saksouk, Vincent Mainguy, Sébastien Bonnet, Jacques Côté, Audrey Courboulin
Publikováno v:
Circulation. 123:1205-1215
Background— Pulmonary artery hypertension (PAH) is a proliferative disorder associated with enhanced pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. The sustainability of this phenotype required the activation of a prosu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b5790054f4c388dd8f03b53393fc97
https://doi.org/10.1161/circulationaha.110.963314
https://doi.org/10.1161/circulationaha.110.963314
Autor:
Sébastien Bonnet, Audrey Courboulin, Roxane Paulin, Steeve Provencher, Eric Paquet, Nehmé Saksouk, Jolyane Meloche, Martin J. Simard, Tanya Perreault, Jacques Côté, Nellie J. Giguère, Sabrina Biardel
Publikováno v:
The Journal of Experimental Medicine
Reduced miR-204 expression facilitates the excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells characteristic of human pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is characterized b
Pulmonary arterial hypertension (PAH) is characterized b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d89734d6aa1a54330ed4b200449ddb
https://doi.org/10.1084/jem.20101812
https://doi.org/10.1084/jem.20101812