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Autor:
Carla J. Pantoja, Haiou Li, Justin Rodante, Andrew Keel, Alexander V. Sorokin, Axel Svedbom, Heather L. Teague, Mona Stahle, Nehal N. Mehta, Martin P. Playford
Publikováno v:
JEADV Clinical Practice, Vol 3, Iss 1, Pp 150-159 (2024)
Abstract Background Beta‐defensins (BDs) are antimicrobial peptides secreted upon epithelial injury. Both chemotactic and antimicrobial properties of BDs function as initial steps in host defence and prime the adaptive immune system in the body. Ps
Externí odkaz:
https://doaj.org/article/cc901c78712444d58bb0d6e7760d1035
Autor:
Amit K. Dey
Publikováno v:
European Heart Journal. 39:1050-1053
Autor:
Sundus S. Lateef, Grace A. Ward, Haiou Li, Carla Pantoja, Elizabeth Florida, Christin G. Hong, Justin Rodante, Andrew Keel, Marcus Y. Chen, Alexander V. Sorokin, Martin P. Playford, Nehal N. Mehta
Publikováno v:
JID Innovations, Vol 4, Iss 1, Pp 100243- (2024)
Psoriasis (PSO) is a chronic and systemic inflammatory autoimmune disease associated with atherosclerosis and myocardial infarction. Given that atherosclerosis is both inflammation and immune driven, we sought to expand on known immune and inflammato
Externí odkaz:
https://doaj.org/article/6713067a693e4efba90af977c2e31aec
Autor:
Elizabeth M. Florida, Haiou Li, Christin G. Hong, Emily L. Ongstad, Ranjitha Gaddipati, Sadichha Sitaula, Vijayalakshmi Varma, Philip M. Parel, Ross O'Hagan, Marcus Y. Chen, Heather L. Teague, Martin P. Playford, Sotirios K. Karathanasis, Anna Collén, Nehal N. Mehta, Alan T. Remaley, Alexander V. Sorokin
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 22 (2023)
Background Psoriasis is a chronic inflammatory condition associated with coronary artery disease risk. Uptake of oxidized low‐density lipoprotein by the lectin‐like low‐density lipoprotein receptor‐1 triggers release of the soluble extracellu
Externí odkaz:
https://doaj.org/article/5bcf70e705264ff1be33e6aca04ba7d0
Autor:
Alexander V. Sorokin, Nidhi Patel, Haiou Li, Christin G. Hong, Maureen Sampson, Ross O’Hagan, Elizabeth M. Florida, Heather L. Teague, Martin P. Playford, Marcus Y. Chen, Nehal N. Mehta, Alan T. Remaley
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-10 (2023)
Abstract Background Psoriasis (PSO) is a skin disorder with systemic inflammation and high coronary artery disease risk. A distinct lipid phenotype occurs in psoriasis, which is characterized by high plasma triglycerides (TGs) with typically normal o
Externí odkaz:
https://doaj.org/article/4fe565bf0bf24da79e4cf187c12c8fad
Autor:
Ross O'Hagan, Li-Yueh Hsu, Haiou Li, Christin G. Hong, Philip M. Parel, Alexander R. Berg, Grigory A. Manyak, Vy Bui, Nidhi H. Patel, Elizabeth M. Florida, Heather L. Teague, Martin P. Playford, Wunan Zhou, Damini Dey, Marcus Y. Chen, Nehal N. Mehta, Alexander V. Sorokin
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20732- (2023)
Background: s: Psoriasis is a disease of systemic inflammation associated with increased cardiometabolic risk. Epicardial adipose tissue (EAT) and thoracic adipose tissue (TAT) are contributing factors for atherosclerosis and cardiac dysfunction. We
Externí odkaz:
https://doaj.org/article/2b273f98f9a240d791ba2c2586c68bf6
Autor:
Masaki Sato, Edward B. Neufeld, Martin P. Playford, Yu Lei, Alexander V. Sorokin, Angel M. Aponte, Lita A. Freeman, Scott M. Gordon, Amit K. Dey, Kianoush Jeiran, Masato Hamasaki, Maureen L. Sampson, Robert D. Shamburek, Jingrong Tang, Marcus Y. Chen, Kazuhiko Kotani, Josephine L.C. Anderson, Robin P.F. Dullaart, Nehal N. Mehta, Uwe J.F. Tietge, Alan T. Remaley
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
BACKGROUND Cellular cholesterol efflux capacity (CEC) is a better predictor of cardiovascular disease (CVD) events than HDL-cholesterol (HDL-C) but is not suitable as a routine clinical assay.METHODS We developed an HDL-specific phospholipid efflux (
Externí odkaz:
https://doaj.org/article/39566e9a46204437a84f2a721f256ea3
Autor:
Leticia Fernandez-Friera, Jorge Solis, Joel M Gelfand, Carlota Abbad-Jaime de Aragón, Emilio Berna-Rico, María Asunción Ballester-Martinez, Pedro Jaén, Nehal N Mehta, Álvaro González-Cantero, María G Barderas
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Life expectancy of patients with psoriasis is reduced by 4–5 years due to cardiovascular disease with an increased risk of myocardial infarction at an earlier age compared with the general population. This increased risk is independent
Externí odkaz:
https://doaj.org/article/5b02c8156c504e24a8d19be98785b887
Autor:
Saaket Agrawal, Marcus D. R. Klarqvist, Nathaniel Diamant, Takara L. Stanley, Patrick T. Ellinor, Nehal N. Mehta, Anthony Philippakis, Kenney Ng, Melina Claussnitzer, Steven K. Grinspoon, Puneet Batra, Amit V. Khera
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Different location of adipose tissue may have different consequences to cardiometabolic risk. Here the authors report that deep learning enabled accurate prediction of specific adipose tissue volumes, and that after adjustment for BMI, visceral adipo
Externí odkaz:
https://doaj.org/article/d7844d42ac8a4868b82bf39c7f4b10d7