Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nehal J, Patel"'
Autor:
Drew M. Nassal, Rebecca Shaheen, Nehal J. Patel, Jane Yu, Nick Leahy, Dimitra Bibidakis, Narasimham L. Parinandi, Thomas J. Hund
Publikováno v:
Cells, Vol 12, Iss 5, p 748 (2023)
Cardiac fibroblasts (CFs) maintain the fibrous extracellular matrix (ECM) that supports proper cardiac function. Cardiac injury induces a transition in the activity of CFs to promote cardiac fibrosis. CFs play a critical role in sensing local injury
Externí odkaz:
https://doaj.org/article/a29e01bbb1b5463981044fe26df50d80
Autor:
Drew M, Nassal, Nehal J, Patel, Sathya D, Unudurthi, Rebecca, Shaheen, Jane, Yu, Peter J, Mohler, Thomas J, Hund
Publikováno v:
The Journal of Biological Chemistry
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::489fe6d1e0962abf301fa87dc4345e10
https://pubmed.ncbi.nlm.nih.gov/34153319
https://pubmed.ncbi.nlm.nih.gov/34153319
Publikováno v:
Expert Opin Ther Targets
Introduction: Cardiac fibrosis contributes to the development of cardiovascular disease (CVD) and arrhythmia. Cardiac fibroblasts (CFs) are collagen-producing cells that regulate extracellular matrix (ECM) homeostasis. A complex signaling network has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cfede265ed21365696b5f4b4287e05
Autor:
Amara Greer-Short, Thomas J. Hund, Peter J. Mohler, Drew M. Nassal, Tony Satroplus, Taylor Howard, Nehal J. Patel
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 315:H794-H801
The mechanisms underlying Ca2+/calmodulin-dependent protein kinase II (CaMKII)-induced arrhythmias in ischemia-reperfusion (I/R) are not fully understood. We tested the hypothesis that CaMKII increases late Na+current ( INa,L) via phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17218bdd540d8ef19457cf809ce9977a
https://doi.org/10.1152/ajpheart.00197.2018
https://doi.org/10.1152/ajpheart.00197.2018
Publikováno v:
Expert Review of Cardiovascular Therapy. 16:59-65
INTRODUCTION In the heart, pathways that transduce extracellular environmental cues (e.g. mechanical force, inflammatory stress) into electrical and/or chemical signals at the cellular level are critical for the organ-level response to chronic biomec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2130074d8c00c72689486ff451deba
https://doi.org/10.1080/14779072.2018.1418664
https://doi.org/10.1080/14779072.2018.1418664
Autor:
Drew M. Nassal, Peter J. Mohler, Jane Yu, Sathya D. Unudurthi, Thomas J. Hund, Rebecca Shaheen, Nehal J. Patel
Publikováno v:
Journal of Biological Chemistry. 297:100893
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890dae6527adba4bc2f316cf93d966fe
https://doi.org/10.1016/j.jbc.2021.100893
https://doi.org/10.1016/j.jbc.2021.100893
Autor:
Drew M. Nassal, Curtis G. Pierson, Shyam S. Bansal, Evelyn Thomas, Nehal J. Patel, Peter J. Mohler, Thomas J. Hund, Jane Yu, Sathya D. Unudurthi
Publikováno v:
Life Sci
Aims Heart failure (HF) is characterized by compromised cardiac structure and function. Previous work has identified a link between upregulation of pro-inflammatory cytokines and HF. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99865505b7757083d2a645eb6c117c2c
https://pubmed.ncbi.nlm.nih.gov/32070706
https://pubmed.ncbi.nlm.nih.gov/32070706
Autor:
Benjamin W Scandling, Drew M. Nassal, Sathya D. Unudurthi, Daniel Gratz, Xianyao Xu, Federica Accornero, Thomas J. Hund, Keith J. Gooch, Peter J. Mohler, Amara Greer-Short, Anuradha Kalyanasundaram, Vadim V. Fedorov, Nehal J. Patel
Publikováno v:
JCI Insight. 4
Increased fibrosis is a characteristic remodeling response to biomechanical and neurohumoral stress and a determinant of cardiac mechanical and electrical dysfunction in disease. Stress-induced activation of cardiac fibroblasts (CFs) is a critical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223a42f2ff8021ccc70ec3d0e41b7f3
https://doi.org/10.1172/jci.insight.131046
https://doi.org/10.1172/jci.insight.131046
Autor:
Nehal J. Patel, Evelyn Thomas, Thomas J. Hund, Alexander J. Winkle, Sathyadev Unudurthi, Daniel Gratz
Publikováno v:
Circulation Research. 125
Heart failure (HF) is a complex disease characterized by compromised cardiac structure and function. Previous work has identified a link between upregulation of pro-inflammatory cytokines, and HF. There is a critical need to gain better understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1850b94a5d0e9927fa0af8cbf43bd5d2
https://doi.org/10.1161/res.125.suppl_1.229
https://doi.org/10.1161/res.125.suppl_1.229
Autor:
Benjamin W Scandling, Nehal J. Patel, Drew M. Nassal, Amara Greer-Short, Thomas J. Hund, Sathya D. Unudurthi, Xianyao Xu, Keith J. Gooch, Peter J. Mohler
Publikováno v:
Circulation Research. 125
Increased fibrosis is associated with cardiac dysfunction and arrhythmias. Activation of quiescent cardiac fibroblasts (CFs) occurs in response to injury although the underlying mechanistic pathways remain unclear. The cytoskeletal protein β IV -spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c186aa07d7ec693fbca29aa6d453b7
https://doi.org/10.1161/res.125.suppl_1.844
https://doi.org/10.1161/res.125.suppl_1.844