Výsledky vyhledávání - "Nehal A. Hamdy"

Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives

Autor: Hatem A. Abdel-Aziz, Amira M. Gamal-Eldeen, Enas A. El-Hussieny, Issa M. I. Fakhr, Nehal A. Hamdy

Publikováno v: European Journal of Medicinal Chemistry. 77:323-333

2-Acetyl tetralin ( 1 ) reacted with N , N -dimethylformamide dimethylacetal (DMF-DMA) to afford the enaminone 3 . The reaction of 3 with piperidine and morpholine afforded the trans enaminone 5a , b , respectively. Compound 3 was treated with primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c154c00873eaf4ec770ad70dd2987f8
https://doi.org/10.1016/j.ejmech.2014.03.021

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Enaminone as Building Blocks in Organic Chemistry: A Novel Route to Polyfunctionally 2-Substituted 5,6,7,8-Tetrahydronaphthalenes and Their Antiviral Evaluation

Autor: Nehal A. Hamdy, Waled M. El-Senousy, Issa M. I. Fakhr

Publikováno v: Journal of Heterocyclic Chemistry. 50:337-343

The enaminone 2 reacts with different reagents to afford anilino, aroylpyridine, 1,3,5-tri-tetrahydronaphthoyl-benzene, pyridine, 2,3,6-trisubstituted pyridines, pyrazole, pyrido[1,2-a]benzimidazole, and hydrazone derivatives 4, 6, 8, 9, 11, 13, 15,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3556982b6ee06f6817aa0040026b7e4
https://doi.org/10.1002/jhet.1080

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Synthesis and Anti-proliferative Activity of Substituted-Anilinoquinazolines and Its Relation to EGFR Inhibition

Autor: Nehal A. Hamdy, Moustafa E. El-Araby, M. Hassan, Khaled A.M. Abouzid, K. A. Saleh, D. A. A El Ella

Publikováno v: Arzneimittelforschung. 62:360-366

4-Anilinoquinazoline is a privileged scaffold in developing small molecule inhibitors of tyrosine kinases (TK) especially epidermal growth factor receptor (EGFR). 2 series belonging to 3'-substituted-4-anilinoquinazoline scaffold were synthesized and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb408c0ffff992cf571de0ee52b5dcf6
https://doi.org/10.1055/s-0032-1312601

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Synthesis of New 2-Substituted 6-Bromo-3-methylthiazolo[3,2-a]- benzimidazole Derivatives and their Biological Activities

Autor: Hatem A. Abdel-Aziz, Amira M. Gamal-Eldeen, Nehal A. Hamdy, Issa M. I. Fakhr

Publikováno v: Zeitschrift für Naturforschung C. 66:7-16

1-(6-Bromo-3-methyl-1,3-thiazolo[3,2-a]benzimidazol-2-yl)ethanone (2) was prepared by bromination at ambient temperature of 1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)ethanone (1). The structure of 2 was determined by single-crystal X-ray diffractio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c08f7c650d642d2b63ba03bc5d9bfde5
https://doi.org/10.1515/znc-2011-1-202

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Synthesis of some new azole, pyrimidine, pyran, and benzo/naphtho[b]furan derivatives incorporating thiazolo[3,2-a]benzimidazole moiety

Autor: Nehal A. Hamdy, Ahmad M. Farag, Issa M. I. Fakhr, Kamal M. Dawood, Hatem A. Abdel-Aziz

Publikováno v: Journal of Heterocyclic Chemistry. 48:355-360

Reaction of E-3-(N,N-dimethylamino)-1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)prop-2-en-1-one (1) with some N-nucleophiles, such as anilines 2a, 2b, 2c, 4-amino-N-pyridin-2-yl-benzenesulfonamide (4a), 4-amino-N-pyrimidin-2-yl-benzenesulfonamide (4b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aeba0c84425d53fa77b9b076b5a93480
https://doi.org/10.1002/jhet.584

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Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8-tetrahydronaphthalene derivatives

Autor: Nehal A. Hamdy, Issa M. I. Fakhr, Hatem A. Abdel-Aziz, Amira M. Gamal-Eldeen

Publikováno v: European Journal of Medicinal Chemistry. 45:463-470

The treatment of 2-bromo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone (1) with pyridine, 2-methylpyridine or 4-methylpyridine afforded their corresponding pyridinum bromides 3a–c. The latter salts reacted with activated acetylene to give the cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaf1371e3ee16d61e535593f30e7a0c
https://doi.org/10.1016/j.ejmech.2009.10.027

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Mast cell, a new player in type 2 diabetes

Autor: Nagwa A Mohamed, Nehal A. Hamdy, Randa Salam

Publikováno v: Kasr Al Ainy Medical Journal. 24:59

Background Mast cells plays critical role in inflammatory diseases, including cardiovascular and metabolic diseases and their associated complications. These cells exert their physiological and pathological activities by releasing granules containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c04b5c2c949c45cabc558933fca53c2
https://doi.org/10.4103/kamj.kamj_18_18

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Synthesis of some novel pyrazolo[1,5-a]pyrimidine, 1,2,4-triazolo[1,5-a]pyrimidine, pyrido[2,3-d]pyrimidine, pyrazolo[5,1-c]-1,2,4-triazine and 1,2,4-triazolo[5,1-c]-1,2,4-triazine derivatives incorporating a thiazolo[3,2-a]benzimidazole moiety

Autor: Nehal A. Hamdy, Hatem A. Abdel-Aziz, Ahmad M. Farag, Issa M. I. Fakhr

Publikováno v: Journal of Heterocyclic Chemistry. 45:1033-1037

E-3-(N,N-Dimethylamino)-1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)prop-2-en-1-one (2) was synthesized by the reaction of 1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)ethanone (1) with dimethylformamide-dimethylacetal. The reaction of 2 with 5-amino-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::967628ad9294966cf8012eead9cfe3a2
https://doi.org/10.1002/jhet.5570450413

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