Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Nehad M. Alajez"'
Autor:
Ramesh Elango, Vishnubalaji Radhakrishnan, Sameera Rashid, Reem Al-Sarraf, Mohammed Akhtar, Khalid Ouararhni, Nehad M. Alajez
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Long noncoding RNAs (lncRNAs) play a critical role in breast cancer pathogenesis, including Triple-Negative Breast Cancer (TNBC) subtype. Identifying the lncRNA expression patterns across different breast cancer subtypes could provide valuab
Externí odkaz:
https://doaj.org/article/5ff5530ce2fc49e1b266232186aa3615
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background The mRNA subcellular localization bears substantial impact in the regulation of gene expression, cellular migration, and adaptation. However, the methods employed for experimental determination of this localization are arduous, ti
Externí odkaz:
https://doaj.org/article/aeb2c47b1d954f1887b8bc2c49058bcf
Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells
Autor:
Dalia Ali, Meshail Okla, Sarah Abuelreich, Radhakrishnan Vishnubalaji, Nicholas Ditzel, Rimi Hamam, Justyna M. Kowal, Ahmed Sayed, Abdullah Aldahmash, Nehad M. Alajez, Moustapha Kassem
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionOsteoporosis is a systemic age-related disease characterized by reduced bone mass and microstructure deterioration, leading to increased risk of bone fragility fractures. Osteoporosis is a worldwide major health care problem and there is
Externí odkaz:
https://doaj.org/article/b9b971464f264e33a46e8edff43f2946
Autor:
Hibah Shaath, Radhakrishnan Vishnubalaji, Ramesh Elango, Dinesh Velayutham, Puthen Veettil Jithesh, Nehad M. Alajez
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic disease and recurrence remains a major clinical challenge. In the era of pr
Externí odkaz:
https://doaj.org/article/5dbea8f2b1d44a91b4733211bcec21d0
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Our recent studies have demonstrated the crucial involvement of FOXA2 in the development of human pancreas. Reduction of FOXA2 expression during the differentiation of induced pluripotent stem cells (iPSCs) into pancreatic islets
Externí odkaz:
https://doaj.org/article/1c67c65a3a854c079aca85b1e4c6d83a
Autor:
Ramesh Elango, Sameera Rashid, Radhakrishnan Vishnubalaji, Reem Al-Sarraf, Mohammed Akhtar, Khalid Ouararhni, Julie Decock, Omar M. E. Albagha, Nehad M. Alajez
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Previous studies have suggested that breast cancer (BC) from the Middle East and North Africa (MENA) is presented at younger age with advanced tumor stage, indicating underlying biological differences. Given the scant transcriptomic data on
Externí odkaz:
https://doaj.org/article/46de994f3f8943249fb29316d5144ad2
Autor:
Hanan Ehtewish, Areej Mesleh, Georgios Ponirakis, Katie Lennard, Hanadi Al Hamad, Mani Chandran, Aijaz Parray, Houari Abdesselem, Patrick Wijten, Julie Decock, Nehad M. Alajez, Marwan Ramadan, Shafi Khan, Raheem Ayadathil, Ahmed Own, Ahmed Elsotouhy, Omar Albagha, Abdelilah Arredouani, Jonathan M. Blackburn, Rayaz A. Malik, Omar M. A. El-Agnaf
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundDementia is a debilitating neurological disease affecting millions of people worldwide. The exact mechanisms underlying the initiation and progression of the disease remain to be fully defined. There is an increasing body of evidence for th
Externí odkaz:
https://doaj.org/article/3746ee9d6b8e49e9aa02d27f759e883b
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Subcellular localization of messenger RNA (mRNAs) plays a pivotal role in the regulation of gene expression, cell migration as well as in cellular adaptation. Experiment techniques for pinpointing the subcellular localization of m
Externí odkaz:
https://doaj.org/article/2722d7586de34d64b60740d8b844c9b2
Autor:
Neyla S. Al-Akl, Olfa Khalifa, Georgios Ponirakis, Aijaz Parray, Marwan Ramadan, Shafi Khan, Mani Chandran, Raheem Ayadathil, Ahmed Elsotouhy, Ahmed Own, Hanadi Al Hamad, Julie Decock, Nehad M. Alajez, Omar Albagha, Rayaz A. Malik, Omar M. A. El-Agnaf, Abdelilah Arredouani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2247 (2024)
Diabetes is recognized as a risk factor for cognitive decline, but the underlying mechanisms remain elusive. We aimed to identify the metabolic pathways altered in diabetes-associated cognitive decline (DACD) using untargeted metabolomics. We conduct
Externí odkaz:
https://doaj.org/article/d364ac213a12411c9ee9d278c2c39960
Autor:
Areej Mesleh, Hanan Ehtewish, Katie Lennard, Houari B. Abdesselem, Fouad Al-Shaban, Julie Decock, Nehad M. Alajez, Abdelilah Arredouani, Mohamed M. Emara, Omar Albagha, Lawrence W. Stanton, Sara A. Abdulla, Jonathan M. Blackburnand, Omar M. A. El-Agnaf
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionAutism spectrum disorder (ASD) is a neurodevelopmental condition characterized by defects in two core domains, social/communication skills and restricted/repetitive behaviors or interests. There is no approved biomarker for ASD diagnosis,
Externí odkaz:
https://doaj.org/article/65e4406e67b549829aa37557b1ed0528