Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Neha V. Kalmankar"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Aggregation of β-amyloid (Aβ) peptide is one of the hallmarks of Alzheimer’s disease (AD) which results in chronic and progressive neurodegeneration of the brain. A recent study by our group have shown the ability of cyclic disulfide-rich peptide
Externí odkaz:
https://doaj.org/article/deb412d2c9304a518229e14d1ac66b86
Publikováno v:
Chemistry – An Asian Journal. 16:2920-2931
Cyclotides, a class of macrocyclic plant peptides, characterized by a cyclic backbone and three inter-locking disulfide bonds, may be divided into two major structural subfamilies, Möbius and Bracelet, based on the presence or absence of a specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f0eff1adca3c533f25b785791e42c9
https://doi.org/10.1002/asia.202100585
https://doi.org/10.1002/asia.202100585
Publikováno v:
Journal of Medicinal Chemistry. 64:7422-7433
Neurotoxic aggregation of β-amyloid (Aβ) peptides is a hallmark of Alzheimer's disease and increased reactive oxygen species (ROS) is an associated process. In the present study, we report the neuroprotective effects of disulfide-rich, circular pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a9c60434e6052d0d1fa610e467883e
https://doi.org/10.1021/acs.jmedchem.1c00033
https://doi.org/10.1021/acs.jmedchem.1c00033
Autor:
Neha V Kalmankar, Murugavel Pavalam, Sowmya Indrakumar, Narayanaswamy Srinivasan, Ramanathan Sowdhamini
Publikováno v:
Database. 2022
Disulphide bonds are stabilizing crosslinks in proteins and serve to enhance their thermal stability. In proteins that are small and rich in disulphide bonds, they could be the major determining factor for the choice of conformational state since the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc31f529aa06ea6454a3d29b5153b454
https://doi.org/10.1093/database/baac005
https://doi.org/10.1093/database/baac005
Publikováno v:
Journal of medicinal chemistry. 64(11)
Neurotoxic aggregation of β-amyloid (Aβ) peptides is a hallmark of Alzheimer's disease and increased reactive oxygen species (ROS) is an associated process. In the present study, we report the neuroprotective effects of disulfide-rich, circular pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a903658e7cfc9b4c2a2d00b2cb55bc4
https://pubmed.ncbi.nlm.nih.gov/34048659
https://pubmed.ncbi.nlm.nih.gov/34048659
Neurotoxic aggregation of β-amyloid (Aβ) peptide is a hallmark of Alzheimer’s disease and increased reactive oxygen species (ROS) is known to be associated with this. Here, we report neuroprotective effects of disulfide-rich, circular peptides fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70478ffd19b929507ea0946ae47a82ad
https://doi.org/10.1101/2021.02.07.430179
https://doi.org/10.1101/2021.02.07.430179
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Clitoria ternatea a perennial climber of the Fabaceae family, is well known for its agricultural and medical applications. It is also currently the only known member of the Fabaceae family that produces abundant amounts of the ultra-stable macrocycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fe51ba891cf30f3fca90b201a1b8dd
http://europepmc.org/articles/PMC7391643
http://europepmc.org/articles/PMC7391643
Publikováno v:
Chemistry – An Asian Journal. 16:2752-2752
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914cc9f8f7700f61204b4118df0ccb8e
https://doi.org/10.1002/asia.202101050
https://doi.org/10.1002/asia.202101050
Autor:
Patnam R. Krishnaswamy, N. Yellappa Gowda, J. Krishnappa, D. Vaigundan, Neha V. Kalmankar, A. V. M. Kutty
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2014 (2014)
BioMed Research International, Vol 2014 (2014)
Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis is invoked from a bioinformatics analysis. Structural consequences of this mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad05eb567ac2f85fadd8a27f0a1c2261
https://doi.org/10.1155/2014/706827
https://doi.org/10.1155/2014/706827
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 82:1101-1112
The Ramachandran map clearly delineates the regions of accessible conformational (phi-) space for amino acid residues in proteins. Experimental distributions of phi, values in high-resolution protein structures, reveal sparsely populated zones within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32c28e740e9290ac251d9627cef78a4
https://doi.org/10.1002/prot.24384
https://doi.org/10.1002/prot.24384