Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Neha U. Patel"'
Autor:
Cyril H. Benes, Anthony C. Faber, Michelle Kelliher, Jeffrey A. Engelman, Kathryn Rizzo, Steven Grant, Jorge Almenara, Mathew J. Garnett, Ultan McDermott, Jessica Boisvert, Neha U. Patel, Justine Roderick, Max Greenberg, Joseph McClanaghan, August Williams, Xunqin Yin, Carlotta Costa, AHyun Choi, Anahita Dastur
Materials & Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b14822c5acd6fb07c51fdf79be930e6
https://doi.org/10.1158/1078-0432.22473366.v1
https://doi.org/10.1158/1078-0432.22473366.v1
Autor:
Anthony C. Faber, Jeffrey A. Engelman, Hiromichi Ebi, Bradley Bernstein, Lecia V. Sequist, Mikhail Dozmorov, Shirley M. Taylor, Sinem E. Sahingur, Zofia Piotrowska, Brad E. Windle, Tara J. Nulton, Maria Gomez-Caraballo, Hannah L. Archibald, Shawn Gillepsie, Angel Garcia, Elizabeth L. Lockerman, Neha U. Patel, Mark T. Hughes, Daniel A.R. Heisey, Yotam Drier, Hillary E. Mulvey, Haichuan Hu, Mark A. Hicks, Konstantinos V. Floros, Jungoh Ham, Hidenori Kitai, Aaron N. Hata, Timothy L. Lochmann, Matthew J. Niederst, Kyung-A Song
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdf55fda2d52240554b29e627d0a09c
https://doi.org/10.1158/1078-0432.22462238
https://doi.org/10.1158/1078-0432.22462238
Autor:
Cyril H. Benes, Anthony C. Faber, Michelle Kelliher, Jeffrey A. Engelman, Kathryn Rizzo, Steven Grant, Jorge Almenara, Mathew J. Garnett, Ultan McDermott, Jessica Boisvert, Neha U. Patel, Justine Roderick, Max Greenberg, Joseph McClanaghan, August Williams, Xunqin Yin, Carlotta Costa, AHyun Choi, Anahita Dastur
Purpose:Effective targeted therapies are lacking for refractory and relapsed T-cell acute lymphoblastic leukemia (T-ALL). Suppression of the NOTCH pathway using gamma-secretase inhibitors (GSI) is toxic and clinically not effective. The goal of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15477f6b40651ca7df1e85c44af1b8a4
https://doi.org/10.1158/1078-0432.c.6528492
https://doi.org/10.1158/1078-0432.c.6528492
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Sup. Table 2. Top 3 functional pathways from ingenuity pathways analysis (IPA) in DTC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74674081412f56da2d0227724443a2d
https://doi.org/10.1158/1078-0432.22470600
https://doi.org/10.1158/1078-0432.22470600
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Sup. Table 1. Genes analyzed by RNA-seq with >1 absolute Log2 fold change between PC9 parental and PC9-DTC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09052a4823e04b6fb850ead8281b89c6
https://doi.org/10.1158/1078-0432.22470603
https://doi.org/10.1158/1078-0432.22470603
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Purpose: EGFR inhibitors (EGFRi) are effective against EGFR-mutant lung cancers. The efficacy of these drugs, however, is mitigated by the outgrowth of resistant cells, most often driven by a secondary acquired mutation in EGFR, T790M. We recently de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c5caf81f01177aab3f3a1c79bfff3b
https://doi.org/10.1158/1078-0432.c.6527628.v1
https://doi.org/10.1158/1078-0432.c.6527628.v1
Autor:
Anthony C. Faber, Jeffrey A. Engelman, Hiromichi Ebi, Bradley Bernstein, Lecia V. Sequist, Mikhail Dozmorov, Shirley M. Taylor, Sinem E. Sahingur, Zofia Piotrowska, Brad E. Windle, Tara J. Nulton, Maria Gomez-Caraballo, Hannah L. Archibald, Shawn Gillepsie, Angel Garcia, Elizabeth L. Lockerman, Neha U. Patel, Mark T. Hughes, Daniel A.R. Heisey, Yotam Drier, Hillary E. Mulvey, Haichuan Hu, Mark A. Hicks, Konstantinos V. Floros, Jungoh Ham, Hidenori Kitai, Aaron N. Hata, Timothy L. Lochmann, Matthew J. Niederst, Kyung-A Song
ZEB1 binding sites found in 1975R2 cells compared to 1975 parental cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a27042f9ca1b22d872df72208f56c4
https://doi.org/10.1158/1078-0432.22462241
https://doi.org/10.1158/1078-0432.22462241
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Sup. Table 3. Fold change of FBX7 from RNA-seq analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165d7225c899c59064ea70a7f27b6742
https://doi.org/10.1158/1078-0432.22470597
https://doi.org/10.1158/1078-0432.22470597
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Figure S1. DTCs upregulate TORC1-mediated MCL-1 translation. Figure S2. High-content cell imaging assay. Figure S3. Genetic inhibition of MCL-1 is sufficient to induce apoptosis following EGFR inhibitor treatment. Figure S4. EGFR mutant tumors (PC9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0f590fae8b05bba56e528b2e7a6d98
https://doi.org/10.1158/1078-0432.22470609
https://doi.org/10.1158/1078-0432.22470609
Autor:
Anthony C. Faber, Hiromichi Ebi, Yasushi Yatabe, Sosipatros Boikos, Aaron N. Hata, Andrew J. Souers, Joel D. Leverson, Hisashi Harada, Jennifer E. Koblinski, Yuko Oya, Brad E. Windle, Colin M. Coon, Krista M. Powell, Bin Hu, Jungoh Ham, Neha U. Patel, Yoshiko Murakami, Timothy L. Lochmann, Sheeba Jacob, Crystal Turner, Yasuyuki Hosono, Kyung-A Song
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ee09d5522026d6ed46bed2a10efa32
https://doi.org/10.1158/1078-0432.22470606.v1
https://doi.org/10.1158/1078-0432.22470606.v1