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pro vyhledávání: '"Neha K. Prasad"'
Publikováno v:
Antimicrobial agents and chemotherapy. 66(5)
The World Health Organization (WHO) has warned that our current arsenal of antibiotics is not innovative enough to face impending infectious diseases, especially those caused by multidrug-resistant Gram-negative pathogens. Although the current precli
Autor:
Mark R. Looney, Shuyan Chen, Michelle Yu, Amy Lyden, Jiuxin Qu, Emily D. Crawford, Jason M. Peters, Melanie R. Silvis, Neha K. Prasad, Oren S. Rosenberg
Pathogens express a set of proteins required for establishing and maintaining an infection, termed virulence life-style genes (VLGs). Due to their outsized importance in pathogenesis, VLG products are attractive targets for the next generation of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491a6de0249f41c0b039f930cbc5c8f0
Publikováno v:
Nature chemical biology. 13(7)
Nonribosomal peptide synthetases (NRPSs) are multidomain modular biosynthetic assembly lines that polymerize amino acids into a myriad of biologically active nonribosomal peptides (NRPs). NRPS thioesterase (TE) domains employ diverse release strategi