Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Neguembor MV"'
Autor:
Cristina Godio, Alexandros Xynos, Gunnar Schotta, Maria Victoria Neguembor, Mariaelena Pistoni, Davide Gabellini, Roberta Caccia, Davide Corona, Sergia Bortolanza, Maria Cristina Onorati
Publikováno v:
Journal of Molecular Cell Biology
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant myopathy with a strong epigenetic component. It is associated with deletion of a macrosatellite repeat leading to over-expression of the nearby genes. Among them, we focused on FS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5e12784fa907d087635638caee810c
https://pubmed.ncbi.nlm.nih.gov/23720823
https://pubmed.ncbi.nlm.nih.gov/23720823
Autor:
Pardo-Lorente N; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Gkanogiannis A; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Cozzuto L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Gañez Zapater A; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Espinar L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Ghose R; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Severino J; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., García-López L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Aydin RG; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Martin L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Neguembor MV; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Darai E; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain., Cosma MP; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Batlle-Morera L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Ponomarenko J; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Sdelci S; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain. sara.sdelci@crg.eu.; Universitat Pompeu Fabra (UPF), Barcelona, Spain. sara.sdelci@crg.eu.
Publikováno v:
Nature communications [Nat Commun] 2024 Nov 12; Vol. 15 (1), pp. 9529. Date of Electronic Publication: 2024 Nov 12.
Autor:
Garate X; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Gómez-García PA; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Merino MF; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Angles MC; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Zhu C; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Castells-García A; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Yuexiu district, 510080 Guangzhou, China., Ed-Daoui I; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Yuexiu district, 510080 Guangzhou, China., Martin L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Ochiai H; Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, 739-0046, Japan., Neguembor MV; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Cosma MP; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Yuexiu district, 510080 Guangzhou, China.; ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Publikováno v:
Nucleic acids research [Nucleic Acids Res] 2024 Aug 12; Vol. 52 (14), pp. 8146-8164.
Autor:
Kant A; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA., Guo Z; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, 19104, USA., Vinayak V; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA., Neguembor MV; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003, Barcelona, Spain., Li WS; Department of Applied Physics, Northwestern University, Evanston, IL, 60208, USA.; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, 60202, USA., Agrawal V; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, 60202, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Pujadas E; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, 60202, USA., Almassalha L; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, 60202, USA.; Department of Gastroenterology and Hepatology, Northwestern Memorial Hospital, Chicago, IL, 60611, USA., Backman V; Center for Physical Genomics and Engineering, Northwestern University, Evanston, IL, 60202, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA., Lakadamyali M; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Cosma MP; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003, Barcelona, Spain.; ICREA, Barcelona, 08010, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain., Shenoy VB; Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, 19104, USA. vshenoy@seas.upenn.edu.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. vshenoy@seas.upenn.edu.; Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, 19104, USA. vshenoy@seas.upenn.edu.
Publikováno v:
Nature communications [Nat Commun] 2024 May 21; Vol. 15 (1), pp. 4338. Date of Electronic Publication: 2024 May 21.
Autor:
Nakagawa S; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Carnevali D; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Tan X; Department of Systems Biology, Columbia University, New York, NY, USA., Alvarez MJ; Department of Systems Biology, Columbia University, New York, NY, USA; DarwinHealth Inc, New York, NY, USA., Parfitt DE; Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Di Vicino U; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Arumugam K; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Shin W; Department of Systems Biology, Columbia University, New York, NY, USA., Aranda S; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Normanno D; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain; Institute of Human Genetics, CNRS, Montpellier, France., Sebastian-Perez R; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Cannatá C; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Cortes P; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Neguembor MV; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Shen MM; Department of Systems Biology, Columbia University, New York, NY, USA; Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Califano A; Department of Systems Biology, Columbia University, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA; Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Biomedical Informatics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Chan Zuckerberg Biohub New York, New York, NY, USA. Electronic address: ac2248@cumc.columbia.edu., Cosma MP; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain; ICREA, Pg.Lluis Companys 23, 08010 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Yuexiu District, Guangzhou 510080, China. Electronic address: pia.cosma@crg.es.
Publikováno v:
Stem cell reports [Stem Cell Reports] 2024 May 14; Vol. 19 (5), pp. 689-709. Date of Electronic Publication: 2024 May 02.
Autor:
Ramírez-Cuéllar J; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Ferrari R; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain.; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy., Sanz RT; Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas (IBMB-CSIC), C/ Baldiri Reixac, 4-8, 08028, Barcelona, Spain., Valverde-Santiago M; Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas (IBMB-CSIC), C/ Baldiri Reixac, 4-8, 08028, Barcelona, Spain., García-García J; Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas (IBMB-CSIC), C/ Baldiri Reixac, 4-8, 08028, Barcelona, Spain., Nacht AS; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain., Castillo D; CNAG-CRG, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Baldiri Reixac 4, Barcelona, 08028, Spain., Le Dily F; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain., Neguembor MV; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain., Malatesta M; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy., Bonnin S; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain., Marti-Renom MA; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CNAG-CRG, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Baldiri Reixac 4, Barcelona, 08028, Spain.; ICREA, Barcelona, Spain., Beato M; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Vicent GP; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST) Barcelona, Barcelona, Spain. gvmbmc@ibmb.csic.es.; Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Científicas (IBMB-CSIC), C/ Baldiri Reixac, 4-8, 08028, Barcelona, Spain. gvmbmc@ibmb.csic.es.
Publikováno v:
The EMBO journal [EMBO J] 2024 May; Vol. 43 (9), pp. 1770-1798. Date of Electronic Publication: 2024 Apr 02.
Autor:
Carnevali D; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Zhong L; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., González-Almela E; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Viana C; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Rotkevich M; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Wang A; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Franco-Barranco D; Department of Computer Science and Artificial Intelligence, University of the Basque Country (UPV/EHU), Paseo Manuel Lardizabal 1, San Sebastian, Spain.; Donostia International Physics Center (DIPC), San Sebastian, Spain., Gonzalez-Marfil A; Department of Computer Science and Artificial Intelligence, University of the Basque Country (UPV/EHU), Paseo Manuel Lardizabal 1, San Sebastian, Spain.; Donostia International Physics Center (DIPC), San Sebastian, Spain., Neguembor MV; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Castells-Garcia A; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China., Arganda-Carreras I; Department of Computer Science and Artificial Intelligence, University of the Basque Country (UPV/EHU), Paseo Manuel Lardizabal 1, San Sebastian, Spain.; Donostia International Physics Center (DIPC), San Sebastian, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.; Biofisika Institute, Barrio Sarrena s/n, Leioa, Spain., Cosma MP; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.; ICREA, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Publikováno v:
Nature machine intelligence [Nat Mach Intell] 2024; Vol. 6 (9), pp. 1021-1033. Date of Electronic Publication: 2024 Aug 27.
Autor:
Christou-Kent M; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Cuartero S; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain; Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain., Garcia-Cabau C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain., Ruehle J; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Naderi J; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany., Erber J; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Neguembor MV; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Plana-Carmona M; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Alcoverro-Bertran M; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain., De Andres-Aguayo L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Klonizakis A; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain., Julià-Vilella E; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain., Lynch C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Altos Labs, Cambridge Institute of Science, Cambridge CB21 6GP, UK., Serrano M; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Altos Labs, Cambridge Institute of Science, Cambridge CB21 6GP, UK., Hnisz D; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany., Salvatella X; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain., Graf T; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain. Electronic address: thomas.graf@crg.eu., Stik G; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain. Electronic address: gstik@carrerasresearch.org.
Publikováno v:
Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112897. Date of Electronic Publication: 2023 Jul 29.
Autor:
Cosma MP; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Yuexiu District, 510080 Guangzhou, China; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Dr Aiguader 88, 08003 Barcelona, Spain; ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain. Electronic address: pia.cosma@crg.es., Neguembor MV; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain. Electronic address: victoire.neguembor@crg.es.
Publikováno v:
Cell reports [Cell Rep] 2023 Apr 25; Vol. 42 (4), pp. 112361. Date of Electronic Publication: 2023 Apr 13.
Autor:
Porter H; Research Department of Cancer Biology, Cancer Institute, University College London, London, United Kingdom., Li Y; Research Department of Cancer Biology, Cancer Institute, University College London, London, United Kingdom., Neguembor MV; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain., Beltran M; Regulatory Genomics Group, Cancer Institute, University College London, London, United Kingdom., Varsally W; Research Department of Cancer Biology, Cancer Institute, University College London, London, United Kingdom., Martin L; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain., Cornejo MT; Regulatory Genomics Group, Cancer Institute, University College London, London, United Kingdom., Pezić D; Research Department of Cancer Biology, Cancer Institute, University College London, London, United Kingdom., Bhamra A; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, United Kingdom., Surinova S; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, United Kingdom., Jenner RG; Regulatory Genomics Group, Cancer Institute, University College London, London, United Kingdom., Cosma MP; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Hadjur S; Research Department of Cancer Biology, Cancer Institute, University College London, London, United Kingdom.
Publikováno v:
ELife [Elife] 2023 Apr 03; Vol. 12. Date of Electronic Publication: 2023 Apr 03.