Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Autor: William J. Young, Jeffrey Haessler, Jan-Walter Benjamins, Linda Repetto, Jie Yao, Aaron Isaacs, Andrew R. Harper, Julia Ramirez, Sophie Garnier, Stefan van Duijvenboden, Antoine R. Baldassari, Maria Pina Concas, ThuyVy Duong, Luisa Foco, Jonas L. Isaksen, Hao Mei, Raymond Noordam, Casia Nursyifa, Anne Richmond, Meddly L. Santolalla, Colleen M. Sitlani, Negin Soroush, Sébastien Thériault, Stella Trompet, Stefanie Aeschbacher, Fariba Ahmadizar, Alvaro Alonso, Jennifer A. Brody, Archie Campbell, Adolfo Correa, Dawood Darbar, Antonio De Luca, Jean-François Deleuze, Christina Ellervik, Christian Fuchsberger, Anuj Goel, Christopher Grace, Xiuqing Guo, Torben Hansen, Susan R. Heckbert, Rebecca D. Jackson, Jan A. Kors, Maria Fernanda Lima-Costa, Allan Linneberg, Peter W. Macfarlane, Alanna C. Morrison, Pau Navarro, David J. Porteous, Peter P. Pramstaller, Alexander P. Reiner, Lorenz Risch, Ulrich Schotten, Xia Shen, Gianfranco Sinagra, Elsayed Z. Soliman, Monika Stoll, Eduardo Tarazona-Santos, Andrew Tinker, Katerina Trajanoska, Eric Villard, Helen R. Warren, Eric A. Whitsel, Kerri L. Wiggins, Dan E. Arking, Christy L. Avery, David Conen, Giorgia Girotto, Niels Grarup, Caroline Hayward, J.Wouter Jukema, Dennis O. Mook-Kanamori, Morten Salling Olesen, Sandosh Padmanabhan, Bruce M. Psaty, Cristian Pattaro, Antonio Luiz P. Ribeiro, Jerome I. Rotter, Bruno H. Stricker, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, James G. Wilson, Michele Orini, Philippe Charron, Hugh Watkins, Charles Kooperberg, Henry J. Lin, James F. Wilson, Jørgen K. Kanters, Nona Sotoodehnia, Borbala Mifsud, Pier D. Lambiase, Larisa G. Tereshchenko, Patricia B. Munroe

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

The spatial and frontal QRS-T angles are electrocardiographic (ECG) predictors for arrhythmia. This work used genetic analyses to identify associated loci and pathways, and explore their relationships with other ECG traits and cardiovascular disease.

Externí odkaz: https://doaj.org/article/dafca92a55c441c48a99162ccb2f3205

QTc-interval prolongation and increased risk of sudden cardiac death associated with hydroxychloroquine

Autor: Maryam Kavousi, Negin Soroush, Jan A. Kors, M. Arfan Ikram, Fariba Ahmadizar, Bruno H. Stricker

Publikováno v: European Journal of Preventive Cardiology, 28(17), 1875-1882. SAGE Publications Ltd
European Journal of Preventive Cardiology

Aims: Hydroxychloroquine and chloroquine ([hydroxy]chloroquine) are drugs used to treat malaria and rheumatological disorders and were recently suggested as beneficial for prevention and treatment of patients with coronavirus disease 2019 (COVID-19)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f262b1995a83a998ae2517f5fb922efc
https://doi.org/10.1093/eurjpc/zwaa118

Association between digoxin use and sudden cardiac death in individuals with the rs10494366 variant of the NOS1AP gene

Autor: Negin Soroush, Fariba Ahmadizar, B. H. Stricker, M.N. Van den Berg, F Shokri, Albert-Jan L.H.J. Aarnoudse

Publikováno v: European Heart Journal. 41

Background Digoxin is one of the oldest cardiovascular medications still used to treat heart failure and atrial fibrillation. Due to its narrow therapeutic window, it is associated with life threatening intoxication and arrhythmias, and with QTc-shor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::634654d560b471ae549acb0c58e6591c
https://doi.org/10.1093/ehjci/ehaa946.3394

Vitamin D receptor gene FokI variant in diabetic foot ulcer and its relation with oxidative stress

Autor: Armita Kakavand Hamidi, Mania Radfar, Mahsa M. Amoli, Negin Soroush, Farideh Razi, Ensieh Nasli Esfahani, Mohammad Abdollahi, Mostafa Qorbani

Publikováno v: Gene. 599

Purpose The patient's suffering and financial costs affiliated with Diabetic Foot Ulcer (DFU), as one of the most important complications of diabetes, are highly undesirable and this highlights the importance of preventive medicine about this disorde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f05062f5d10f6abaf0897573c0d3916
https://pubmed.ncbi.nlm.nih.gov/27836663