Trans-nasal brain delivery of anti-TB drugs by methyl-β-cyclodextrin microparticles show efficient mycobacterial clearance from central nervous system

Autor: Jadhav, Krishna ^a, Jhilta, Agrim ^a, Singh, Raghuraj ^{a, d}, Sharma, Shweta ^b, Negi, Swarnima ^a, Ahirwar, Kailash ^c, Shukla, Rahul ^c, Singh, Amit Kumar ^{b, d, 1, ∗∗}, Verma, Rahul Kumar ^{a, d, ⁎, 1}

Publikováno v: In Journal of Controlled Release 10 February 2025 378:671-686

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Trans-nasal brain delivery of anti-TB drugs by methyl-β-cyclodextrin microparticles show efficient mycobacterial clearance from central nervous system.

Autor: Jadhav K; Pharmaceutical Nanotechnology Lab, Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab 140306, India., Jhilta A; Pharmaceutical Nanotechnology Lab, Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab 140306, India., Singh R; Pharmaceutical Nanotechnology Lab, Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab 140306, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India., Sharma S; Experimental Animal Facility, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, India., Negi S; Pharmaceutical Nanotechnology Lab, Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab 140306, India., Ahirwar K; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Bijnor-Sisendi Road, Lucknow, UP 226002, India., Shukla R; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Bijnor-Sisendi Road, Lucknow, UP 226002, India., Singh AK; Experimental Animal Facility, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282004, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India., Verma RK; Pharmaceutical Nanotechnology Lab, Institute of Nano Science and Technology (INST), Sector-81, Mohali, Punjab 140306, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India. Electronic address: rahulverma@inst.ac.in.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Dec 15. Date of Electronic Publication: 2024 Dec 15.