EMA Recommendation for the Pediatric Indications of Plerixafor (Mozobil) to Enhance Mobilization of Hematopoietic Stem Cells for Collection and Subsequent Autologous Transplantation in Children with Lymphoma or Malignant Solid Tumors

Autor: Irene Papadouli, Filip Josephson, Sabine Straus, Geanne Thole, Paula van Hennik, Pieter J Glerum, Sahra Ali, Dominik Karres, Carla Herberts, Negar Babae, Ralf Herold, Francesco Pignatti

Publikováno v: Oncologist

On March 28, 2019, the Committee for Medicinal Products for Human Use adopted a positive opinion recommending the marketing authorization for the medicinal product plerixafor. The marketing authorization holder for this medicinal product is Genzyme E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172ef25d819186c8d1650023d181d35c
https://doi.org/10.1634/theoncologist.2019-0898

Anginex lipoplexes for delivery of anti-angiogenic siRNA

Autor: Judy R. van Beijnum, Raymond M. Schiffelers, Paula I. van Noort, Arjan W. Griffioen, Afrouz Yousefi, Negar Babae, Roel Q.J. Schaapveld, Enrico Mastrobattista, Gert Storm, Meriem Bourajjaj

Publikováno v: International journal of pharmaceutics, 472(1-2), 175-184. Elsevier
Yousefi, A, Bourajjaj, M, Babae, N, van Noort, P I, Schaapveld, R Q J, van Beijnum, J R, Griffioen, A W, Storm, G, Schiffelers, R M & Mastrobattista, E 2014, ' Anginex lipoplexes for delivery of anti-angiogenic siRNA ', International journal of pharmaceutics, vol. 472, no. 1-2, pp. 175-184 . https://doi.org/10.1016/j.ijpharm.2014.06.028

Angiogenesis is one of the hallmarks of cancer which renders it an attractive target for therapy of malignancies. Tumor growth suppression can be achieved by inhibiting angiogenesis since it would deprive tumor cells of oxygen and vital nutrients. Ac

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https://research.vumc.nl/en/publications/2f3f1abb-c6c5-483c-a1ef-aaec7b9d25da

Abstract 1112: Identification of microRNA-based therapeutic candidates using a unique lentiviral microRNA overexpression library

Autor: Paula I. van Noort, Negar Babae, Jos B. Poell, Meriem Bourajjaj, Suzana Vidic, Judy R. van Beijnum, Rick J. van Haastert, Iman Schultz, Thijs de Gunt, Onno van Hooij, Gerald W. Verhaegh, Willemijn M. Gommans, Francesco Cerisoli, Mark Verheul, Raymond M. Schiffelers, Arjan W. Griffioen, Jack A. Schalken, Eugene Berezikov, Edwin Cuppen, Roel QJ Schaapveld, Gregoire P. Prevost

Publikováno v: Cancer Research. 72:1112-1112

microRNA (miRNA) genes transcribed by RNA polymerase II generate small noncoding miRNAs of 18 to 24 nucleotides after maturation process. The mature miRNAs and their associated isomirs specifically bind to different mRNA transcripts, resulting in dow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68d541876cd121ed78b947f634925e91
https://doi.org/10.1158/1538-7445.am2012-1112

Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma

Autor: Maaike van Berkel, Francesco Cerisoli, Raymond M. Schiffelers, Paula I. van Noort, Mark Verheul, Judy R. van Beijnum, Yijia Liu, Rick Jan van Haastert, Gert Storm, Martin C. Woodle, Grégoire Pierre André Prevost, Roel Q.J. Schaapveld, Enrico Mastrobattista, Ebel H. E. Pieters, Arjan W. Griffioen, Puthupparampil V. Scaria, Meriem Bourajjaj, Afrouz Yousefi, Eugene Berezikov, Negar Babae, Edwin Cuppen

Publikováno v: Scopus-Elsevier
Oncotarget, 5(16), 6687-700. Impact Journals
Oncotarget, 5(16), 6687. Impact Journals
Babae, N, Bourajjaj, M, Liu, Y, van Beijnum, J R, Cerisoli, F, Scaria, P V, Verheul, M, van Berkel, M P A, Pieters, E H E, van Haastert, R J, Yousefi, A, Mastrobattista, E, Storm, G, Berezikov, E, Cuppen, E, Woodle, M, Schaapveld, R Q J, Prevost, G P, Griffioen, A W, van Noort, P I & Schiffelers, R M 2014, ' Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma ', Oncotarget, vol. 5, no. 16, pp. 6687-6700 . https://doi.org/10.18632/oncotarget.2235
Oncotarget, 5(16), 6687-6700. Impact Journals
Oncotarget

Tumor-angiogenesis is the multi-factorial process of sprouting of endothelial cells (EC) into micro-vessels to provide tumor cells with nutrients and oxygen. To explore miRNAs as therapeutic angiogenesis-inhibitors, we performed a functional screen t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c255cfa43fb16310d4f1f95a0380ba4
http://www.scopus.com/inward/record.url?eid=2-s2.0-84907069647&partnerID=MN8TOARS