Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

Autor: Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero, Manoocher Soleimani

Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-21 (2020)

Abstract Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads to severe cerebellar d

Externí odkaz: https://doaj.org/article/e46b17a9098241a499821fe366620d0f

A dynamic balance between neuronal death and clearance after acute brain injury

Autor: Trevor Balena, Kyle Lillis, Negah Rahmati, Fatemeh Bahari, Volodymyr Dzhala, Eugene Berdichevsky, Kevin Staley

Publikováno v: bioRxiv

After acute brain injury, neuronal apoptosis may overwhelm the capacity for microglial phagocytosis, creating a queue of dying neurons awaiting clearance. The size of this queue should be equally sensitive to changes in neuronal death and the rate of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa5d8b25e053b1db8cb549f149707b7
https://doi.org/10.1101/2023.02.14.528332

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

Autor: Nupur Dasgupta, Kamyar Zahedi, Sharon Barone, Diana M. Lindquist, Robert A. Casero, John L. Cleveland, Steve Davidson, Matthew Dunworth, Negah Rahmati, Manoocher Soleimani, Tracy Murray Stewart, Marybeth Brooks, Roger D. Smith, Christine E. Fuller, Christina Destefano-Shields

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-21 (2020)

Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads to severe cerebellar damage and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3af0385456e70c1ee1e5c851f931fb5
http://europepmc.org/articles/PMC7559641

Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels

Autor: Saša Peter, Chris I. De Zeeuw, Negah Rahmati, Freek E. Hoebeek

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience [E], 12. Frontiers Research Foundation
Frontiers in Cellular Neuroscience, 12:101. Frontiers Media SA
Frontiers in Cellular Neuroscience, 12:101. Frontiers Media S.A.
Frontiers in Cellular Neuroscience

The intraneuronal ionic composition is an important determinant of brain functioning. There is growing evidence that aberrant homeostasis of the intracellular concentration of Cl- ([Cl-]i) evokes, in addition to that of Na+ and Ca2+, robust impairmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b2c088953cc20fc85dd0e727f39159
http://journal.frontiersin.org/article/10.3389/fncel.2018.00101/full

SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination

Autor: Chris I. De Zeeuw, Manoocher Soleimani, Martijn Schonewille, María Fernanda Vinueza Veloz, Sharon Barone, Jie Xu, Freek E. Hoebeek, Negah Rahmati, Nahuel Rodolfo Ben Hamida

Publikováno v: eNeuro, 3(3):e0028-16.2016. Society for Neuroscience

Chloride homeostasis determines the impact of inhibitory synaptic transmission and thereby mediates the excitability of neurons. Even though cerebellar Purkinje cells (PCs) receive a pronounced inhibitory GABAergic input from stellate and basket cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3626102837ff8647dbea3e5b7dfaa0
https://doi.org/10.1523/eneuro.0028-16.2016