TINC - a method to dissect transcriptional complexes at single locus resolution - reveals novel Nanog regulators in mouse embryonic stem cells

Autor: Knaupp, AS, Mohenska, M, Larcombe, MR, Ford, E, Lim, SM, Wong, K, Chen, J, Firas, J, Huang, C, Liu, X, Nguyen, T, Sun, YBY, Holmes, ML, Tripathi, P, Rossello, FJ, Schröder, J, Nefzger, CM, Das, PP, Haigh, JJ, Lister, R, Schittenhelm, RB, Polo, JM

Cellular identity is ultimately controlled by transcription factors (TFs), which bind to specific regulatory elements (REs) within the genome to regulate gene expression and cell fate changes. While recent advances in genome-wide epigenetic profiling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b0762af213a00bbc68f1781594c046
https://doi.org/10.1101/2020.04.03.023200

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening.

Autor: Patrick R; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Naval-Sanchez M; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Deshpande N; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia; WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Huang Y; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Zhang J; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Chen X; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Yang Y; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Tiwari K; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Esmaeili M; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Tran M; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Mohamed AR; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Wang B; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Xia D; Genome Innovation Hub, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Ma J; Genome Innovation Hub, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Bayliss J; Department of Anatomy and Physiology, Faculty of Medicine Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia., Wong K; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Hun ML; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Sun X; Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organization, Melbourne, VIC, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia., Cao B; Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organization, Melbourne, VIC, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia., Cottle DL; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Catterall T; St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia., Barzilai-Tutsch H; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia; Institut NeuroMyoGène, University Claude Bernard Lyon 1, 69008 Lyon, France., Troskie RL; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Chen Z; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Wise AF; Department of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Saini S; Department of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Soe YM; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Kumari S; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Sweet MJ; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia., Thomas HE; St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia., Smyth IM; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Fletcher AL; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Knoblich K; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Watt MJ; Department of Anatomy and Physiology, Faculty of Medicine Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia., Alhomrani M; Department of Clinical Laboratories Sciences, Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia; Research Centre for Health Sciences, Taif University, Taif, Saudi Arabia., Alsanie W; Department of Clinical Laboratories Sciences, Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia; Research Centre for Health Sciences, Taif University, Taif, Saudi Arabia., Quinn KM; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia., Merson TD; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia; National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA., Chidgey AP; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Ricardo SD; Department of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Yu D; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia; Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Jardé T; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Surgery, Cabrini Monash University, Malvern, VIC 3144, Australia., Cheetham SW; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Marcelle C; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia; Institut NeuroMyoGène, University Claude Bernard Lyon 1, 69008 Lyon, France., Nilsson SK; Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organization, Melbourne, VIC, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia., Nguyen Q; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia; School of Biomedical Sciences, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., White MD; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia; School of Biomedical Sciences, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Nefzger CM; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia. Electronic address: c.nefzger@imb.uq.edu.au.

Publikováno v: Cell metabolism [Cell Metab] 2024 Aug 06; Vol. 36 (8), pp. 1858-1881.e23. Date of Electronic Publication: 2024 Jul 02.

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm.

Autor: Wu Z; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Shen S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Mizikovsky D; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Cao Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Naval-Sanchez M; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Tan SZ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Alvarez YD; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Sun Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Chen X; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Zhao Q; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Kim D; Children's Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia., Yang P; Children's Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia., Hill TA; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Jones A; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Fairlie DP; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia., Pébay A; Department of Anatomy and Physiology, The University of Melbourne, Parkville, VIC 3010, Australia; Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3010, Australia., Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia., Tam PPL; Children's Medical Research Institute, The University of Sydney, Westmead, NSW 2145, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia., White MD; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Nefzger CM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, Brisbane, QLD 4067, Australia., Palpant NJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: n.palpant@uq.edu.au.

Publikováno v: Developmental cell [Dev Cell] 2024 Mar 25; Vol. 59 (6), pp. 705-722.e8. Date of Electronic Publication: 2024 Feb 13.

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release.

Autor: Labzin LI; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia., Chew KY; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia., Eschke K; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Wang X; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, QLD 4072, Australia., Esposito T; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, QLD 4072, Australia., Stocks CJ; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, QLD 4072, Australia., Rae J; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia., Patrick R; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Mostafavi H; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Hill B; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Yordanov TE; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Holley CL; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, QLD 4072, Australia., Emming S; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, QLD 4072, Australia., Fritzlar S; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Mordant FL; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Steinfort DP; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Respiratory Medicine, Royal Melbourne Hospital, Parkville, VIC 3052, Australia., Subbarao K; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.; WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Nefzger CM; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Lagendijk AK; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Gordon EJ; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia., Parton RG; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD 4072, Australia., Short KR; Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia.; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia., Londrigan SL; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Schroder K; Institute for Molecular Bioscience (IMB), University of Queensland, Brisbane, QLD 4072, Australia.; IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, QLD 4072, Australia.; Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia.; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.

Publikováno v: Science signaling [Sci Signal] 2023 Apr 25; Vol. 16 (782), pp. eabq1366. Date of Electronic Publication: 2023 Apr 25.

Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells.

Autor: Gerdes P; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia., Lim SM; Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Melbourne, VIC, 3800, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, 3800, Australia., Ewing AD; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia., Larcombe MR; Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Melbourne, VIC, 3800, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, 3800, Australia., Chan D; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia., Sanchez-Luque FJ; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia.; GENYO. Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research, PTS, Granada, 18016, Spain., Walker L; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia., Carleton AL; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia., James C; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia., Knaupp AS; Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Melbourne, VIC, 3800, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, 3800, Australia., Carreira PE; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia., Nefzger CM; Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC, 3800, Australia.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Melbourne, VIC, 3800, Australia.; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, 3800, Australia., Lister R; Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, WA, 6009, Australia.; Harry Perkins Institute of Medical Research, Perth, WA, 6009, Australia., Richardson SR; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia. sandra.richardson@mater.uq.edu.au., Polo JM; Department of Anatomy & Developmental Biology, Monash University, Melbourne, VIC, 3800, Australia. jose.polo@monash.edu.; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Melbourne, VIC, 3800, Australia. jose.polo@monash.edu.; Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, 3800, Australia. jose.polo@monash.edu.; Adelaide Centre for Epigenetics and The South Australian Immunogenomics Cancer Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia. jose.polo@monash.edu., Faulkner GJ; Mater Research Institute - University of Queensland, TRI Building, Woolloongabba, QLD, 4102, Australia. faulknergj@gmail.com.; Queensland Brain Institute, University of Queensland, Brisbane, QLD, 4072, Australia. faulknergj@gmail.com.

Publikováno v: Nature communications [Nat Commun] 2022 Dec 03; Vol. 13 (1), pp. 7470. Date of Electronic Publication: 2022 Dec 03.