MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo

Autor: Lorenzo Dagna, Richard A. Spritz, Ying Jin, Brent E. Palmer, Henry A. Erlich, Melinda Rastrou, Giulio Cavalli, Daniel Yorgov, Isak W. Tengesdal, Stephanie A. Santorico, Cherie Holcomb, Charles A. Dinarello, C. Preston Neff, Masahiro Hayashi

Publikováno v: Proceedings of the National Academy of Sciences USA, 113, 1363-8
Proceedings of the National Academy of Sciences USA, 113, 5, pp. 1363-8

Item does not contain fulltext Genetic risk for autoimmunity in HLA genes is most often attributed to structural specificity resulting in presentation of self-antigens. Autoimmune vitiligo is strongly associated with the MHC class II region. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6246746bcc2a545c4aa580d1f49147b
http://hdl.handle.net/2066/170910

Differential effects of antiretroviral treatment on immunity and gut microbiome composition in people living with HIV in rural versus urban Zimbabwe.

Autor: Burkhart Colorado AS; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Lazzaro A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185, Rome, Italy., Neff CP; Department Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Nusbacher N; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Boyd K; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, England., Fiorillo S; Department Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Martin C; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Siebert JC; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Campbell TB; Department Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Borok M; Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Palmer BE; Department Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. BRENT.PALMER@CUANSCHUTZ.EDU., Lozupone C; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Catherine.lozupone@cuanschutz.edu.

Publikováno v: Microbiome [Microbiome] 2024 Feb 03; Vol. 12 (1), pp. 18. Date of Electronic Publication: 2024 Feb 03.

Antiretroviral treatment is less effective at reducing gut microbiome-associated inflammation and T cell activation in people living with HIV in rural versus urban Zimbabwe.

Autor: Lazzaro A; Sapienza University of Rome., Colorado ASB; University of Colorado Anschutz Medical Campus., Neff CP; University of Colorado Anschutz Medical Campus., Nusbacher N; University of Colorado Anschutz Medical Campus., Boyd K; London School of Hygiene & Tropical Medicine., Fiorillo S; University of Colorado Anschutz Medical Campus., Martin C; University of Colorado Anschutz Medical Campus., Siebert J; University of Colorado Anschutz Medical Campus., Campbell T; University of Colorado Anschutz Medical Campus., Borok M; University of Zimbabwe., Palmer B; University of Colorado Anschutz Medical Campus., Lozupone C; University of Colorado Anschutz Medical Campus.

Publikováno v: Research square [Res Sq] 2023 Aug 31. Date of Electronic Publication: 2023 Aug 31.

Nucleocapsid protein binding DNA aptamers for detection of SARS-COV-2.

Autor: Neff CP; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Cikara M; Precision Medicine Architects, LLC, PO Box 148, Wellington, CO 80549, United States., Geiss BJ; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA., Thomas Caltagirone G; Aptagen, LLC, 250 North Main Street, Jacobus, PA 17407, USA., Liao A; Aptagen, LLC, 250 North Main Street, Jacobus, PA 17407, USA., Atif SM; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Macdonald B; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Schaden R; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Publikováno v: Current research in biotechnology [Curr Res Biotechnol] 2023; Vol. 5, pp. 100132. Date of Electronic Publication: 2023 May 27.

SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2.

Autor: Littlefield KM; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Watson RO; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Schneider JM; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Neff CP; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Yamada E; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Zhang M; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Campbell TB; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Falta MT; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Jolley SE; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Fontenot AP; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Palmer BE; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2022 May 26; Vol. 18 (5), pp. e1010359. Date of Electronic Publication: 2022 May 26 (Print Publication: 2022).