Zobrazeno 1 - 10 of 338 pro vyhledávání: '"Neeves J"'
1
Akademický článek
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition.
Autor: Ziff OJ; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK; National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, WC1N 3BG London, UK. Electronic address: o.ziff@ucl.ac.uk., Harley J; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK; Institute of Molecular and Cell Biology, A(∗)STAR Research Entities, Singapore 138673, Singapore., Wang Y; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK., Neeves J; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK., Tyzack G; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK., Ibrahim F; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK., Skehel M; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK., Chakrabarti AM; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK., Kelly G; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK., Patani R; The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, WC1N 3BG London, UK; National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, WC1N 3BG London, UK. Electronic address: rickie.patani@ucl.ac.uk.
Publikováno v: Neuron [Neuron] 2023 Oct 04; Vol. 111 (19), pp. 3011-3027.e7. Date of Electronic Publication: 2023 Jul 21.
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2
Akademický článek
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.
Autor: Ziff OJ; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. o.ziff@ucl.ac.uk.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK. o.ziff@ucl.ac.uk.; National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, WC1N 3BG, UK. o.ziff@ucl.ac.uk., Neeves J; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Mitchell J; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Tyzack G; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Martinez-Ruiz C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Luisier R; Genomics and Health Informatics Group, Idiap Research Institute, Martigny, Switzerland., Chakrabarti AM; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Litchfield K; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Boulton SJ; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Kelly G; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Humphrey J; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Patani R; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. rickie.patani@ucl.ac.uk.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK. rickie.patani@ucl.ac.uk.; National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, WC1N 3BG, UK. rickie.patani@ucl.ac.uk.
Publikováno v: Nature communications [Nat Commun] 2023 Apr 20; Vol. 14 (1), pp. 2176. Date of Electronic Publication: 2023 Apr 20.
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3
Akademický článek
Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis.
Autor: Petrić Howe M; The Francis Crick Institute, London NW1 1AT, United Kingdom.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3AR, United Kingdom., Crerar H; The Francis Crick Institute, London NW1 1AT, United Kingdom.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3AR, United Kingdom., Neeves J; The Francis Crick Institute, London NW1 1AT, United Kingdom.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3AR, United Kingdom., Harley J; The Francis Crick Institute, London NW1 1AT, United Kingdom.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3AR, United Kingdom., Tyzack GE; The Francis Crick Institute, London NW1 1AT, United Kingdom.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3AR, United Kingdom., Klein P; The Francis Crick Institute, London NW1 1AT, United Kingdom.; Research Department of Structural and Molecular Biology, University College London, London WC1E 6XA, United Kingdom., Ramos A; Research Department of Structural and Molecular Biology, University College London, London WC1E 6XA, United Kingdom., Patani R; The Francis Crick Institute, London NW1 1AT, United Kingdom.; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3AR, United Kingdom., Luisier R; Idiap Research Institute, Genomics and Health Informatics, CH-1920 Martigny, Switzerland.; SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Publikováno v: Genome research [Genome Res] 2022 Oct; Vol. 32 (10), pp. 1808-1825. Date of Electronic Publication: 2022 Sep 30.
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4
Akademický článek
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis.
Autor: Tyzack GE; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Neeves J; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Crerar H; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Klein P; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Ziff O; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Taha DM; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.; Zoology Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt., Luisier R; Genomics and Health Informatics Group, Idiap Research Institute, CH - 1920 Martigny, Switzerland., Luscombe NM; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; UCL Genetics Institute, University College London, London, WC1E 6BT, UK.; Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan., Patani R; Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Publikováno v: Brain : a journal of neurology [Brain] 2021 Aug 17; Vol. 144 (7), pp. 1985-1993.
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5
Akademický článek
Reactive astrocytes in ALS display diminished intron retention.
Autor: Ziff OJ; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.; National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, WC1N 3BG, UK., Taha DM; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.; Department of Zoology, Faculty of Science, Alexandria University, Alexandria 21511, Egypt., Crerar H; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Clarke BE; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Chakrabarti AM; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, UK., Kelly G; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Neeves J; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Tyzack GE; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK., Luscombe NM; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, UK.; Okinawa Institute of Science & Technology Graduate University, Okinawa 904-0495, Japan., Patani R; The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.; National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, WC1N 3BG, UK.
Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Apr 06; Vol. 49 (6), pp. 3168-3184.
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6
Akademický článek
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB.
Autor: Clarke, Benjamin E.1,2 (AUTHOR) ben.clarke@crick.ac.uk, Ziff, Oliver J.1,2,3 (AUTHOR) oliver.ziff@crick.ac.uk, Tyzack, Giulia1,2 (AUTHOR), Howe, Marija Petrić1,2 (AUTHOR), Wang, Yiran1,2 (AUTHOR), Klein, Pierre1,2 (AUTHOR), Smith, Claudia A.4 (AUTHOR), Hall, Cameron A.4 (AUTHOR), Helmy, Adel4 (AUTHOR), Howell, Michael2 (AUTHOR), Kelly, Gavin2 (AUTHOR), Patani, Rickie1,2,3 (AUTHOR) rickie.patani@ucl.ac.uk
Publikováno v: Molecular Neurodegeneration. 11/26/2024, Vol. 19 Issue 1, p1-24. 24p.
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7
Akademický článek
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8
Akademický článek
Understanding Amyotrophic Lateral Sclerosis: Pathophysiology, Diagnosis, and Therapeutic Advances.
Autor: Rizea, Radu Eugen1,2 (AUTHOR) radu.rizea@umfcd.ro, Corlatescu, Antonio-Daniel1 (AUTHOR) antonio.corlatescu0920@stud.umfcd.ro, Costin, Horia Petre1 (AUTHOR) horia-petre.costin0720@stud.umfcd.ro, Dumitru, Adrian1,3,4 (AUTHOR) prof.avciurea@gmail.com, Ciurea, Alexandru Vlad1,5 (AUTHOR)
Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9966. 21p.
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9
Akademický článek
Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders.
Autor: Kisby, Glen E.1 (AUTHOR) gkisby@westernu.edu, Wilson III, David M.2 (AUTHOR) david.wilson@uhasslet.be, Spencer, Peter S.3 (AUTHOR) gkisby@westernu.edu
Publikováno v: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 13, p7221. 21p.
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10
Akademický článek
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.
Autor: Tyzack GE; The Francis Crick Institute, 1 Midland Road, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Luisier R; The Francis Crick Institute, 1 Midland Road, London, UK., Taha DM; The Francis Crick Institute, 1 Midland Road, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Neeves J; The Francis Crick Institute, 1 Midland Road, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Modic M; The Francis Crick Institute, 1 Midland Road, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Mitchell JS; The Francis Crick Institute, 1 Midland Road, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Meyer I; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Greensmith L; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Newcombe J; NeuroResource, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Ule J; The Francis Crick Institute, 1 Midland Road, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK., Luscombe NM; The Francis Crick Institute, 1 Midland Road, London, UK.; UCL Genetics Institute, University College London, Gower Street, London, UK.; Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan., Patani R; The Francis Crick Institute, 1 Midland Road, London, UK.; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Publikováno v: Brain : a journal of neurology [Brain] 2019 Sep 01; Vol. 142 (9), pp. 2572-2580.
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