Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Neeti Ananthaswamy"'
Autor:
Jingen Zhu, Himanshu Batra, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Xiaorong Wu, Wenzheng Guo, Andrei Fokine, Venigalla B. Rao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications. Here, we describe an assembly-line approach to build AVVs by engineering the well
Externí odkaz:
https://doaj.org/article/f876df16271b41faa46a7605e13a1ee3
Autor:
Jingen Zhu, Swati Jain, Jian Sha, Himanshu Batra, Neeti Ananthaswamy, Paul B. Kilgore, Emily K. Hendrix, Yashoda M. Hosakote, Xiaorong Wu, Juan P. Olano, Adeyemi Kayode, Cristi L. Galindo, Simran Banga, Aleksandra Drelich, Vivian Tat, Chien-Te K. Tseng, Ashok K. Chopra, Venigalla B. Rao
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The U.S. Food and Drug Administration-authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in preventing COVID-19, but they do not induce efficient mucosal immunity or prevent vira
Externí odkaz:
https://doaj.org/article/bce3c0d8931d4e4fb22673c9a20b9eda
Autor:
Neeti Ananthaswamy, Qianglin Fang, Wadad AlSalmi, Swati Jain, Zhenguo Chen, Thomas Klose, Yingyuan Sun, Yue Liu, Marthandan Mahalingam, Subhash Chand, Sodsai Tovanabutra, Merlin L. Robb, Michael G. Rossmann, Venigalla B. Rao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Here, the authors present the structure of the HIV envelope (Env) protein from a transmitted founder virus and show that, while the overall structure of the Env trimer is similar to other closed trimers, the fusion peptide is buried in the hydrophobi
Externí odkaz:
https://doaj.org/article/c550b5e3e0bf452baf0fa1bf3de54854
Autor:
Nick Keller, Douglas E. Smith, Venigalla B. Rao, Stephen C. Harvey, Youbin Mo, Neeti Ananthaswamy, Damian delToro
Publikováno v:
Nucleic Acids Research
Many viruses employ ATP-powered motors during assembly to translocate DNA into procapsid shells. Previous reports raise the question if motor function is modulated by substrate DNA sequence: (i) the phage T4 motor exhibits large translocation rate fl
Publikováno v:
Vaccine Design ISBN: 9781071618837
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6495565cd7d3c2e4d746216f07959e63
https://doi.org/10.1007/978-1-0716-1884-4_10
https://doi.org/10.1007/978-1-0716-1884-4_10
Autor:
Jingen Zhu, Douglass A. Lewry, Sunil A. David, Chien Te K. Tseng, Himanshu Batra, Swati Jain, Venigalla B. Rao, Wei Chun Tang, Michael L. Richards, Aleksandra Drelich, Jian Sha, Paul B. Kilgore, Neeti Ananthaswamy, Ashok K. Chopra
Publikováno v:
bioRxiv
A “universal” vaccine design platform that can rapidly generate multiplex vaccine candidates is critically needed to control future pandemics. Here, using SARS-CoV-2 pandemic virus as a model, we have developed such a platform by CRISPR engineeri
Autor:
Neeti Ananthaswamy, Camille Lange, Haitao Hu, Himanshu Batra, Venigalla B. Rao, Mary F. Kearney, Frank Maldarelli, Jingen Zhu, Marthandan Mahalingam, Pan Tao, Chaojie Zhong, Swati Jain
The latent HIV-1 reservoir containing stably integrated and transcriptionally silent proviruses in CD4+ T cells is a major barrier for virus eradication. Targeted reactivation of the latent reservoir remains a major challenge in establishing a path f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a19fa7ff829aaf4f4683f2d3ebd36e7
https://doi.org/10.1101/2021.07.20.453091
https://doi.org/10.1101/2021.07.20.453091
Autor:
Neeti Ananthaswamy, Marthandan Mahalingam, Christopher Hamlin, Guofen Gao, Dalia Flores, Venigalla B. Rao, Wadad Alsalmi
Publikováno v:
The Journal of Biological Chemistry
Background: HIV-1 envelope trimer is a candidate for designing an effective HIV vaccine. Results: gp140 attached to Strep-tag through a long linker is used to purify HIV trimers. Cleaved, uncleaved, and fully and partially glycosylated trimers are ch
Autor:
Merlin L. Robb, Victor Padilla-Sanchez, Neeti Ananthaswamy, Subhash Chand, Venigalla B. Rao, Guofen Gao, Emily L. Messina, Wadad Alsalmi, Gherman Uritskiy, Mangala Rao, Kristina K. Peachman, Marthandan Mahalingam
Publikováno v:
Virology. 508
The α4s7 integrin present on host cells recognizes the V1V2 domain of the HIV-1 envelope protein. This interaction might be involved in virus transmission. Administration of α4s7-specific antibodies inhibit acquisition of SIV in a macaque challenge
Autor:
Neeti Ananthaswamy, Ildiko M. Kovach, John Golin, Christopher Furman, Nidhi Arya, Bridget Kulesh, Jitender Mehla, Suresh V. Ambudkar
Publikováno v:
Journal of Biological Chemistry. 288:30420-30431
Pdr5 is the founding member of a large subfamily of evolutionarily distinct, clinically important fungal ABC transporters containing a characteristic, deviant ATP-binding site with altered Walker A, Walker B, Signature (C-loop), and Q-loop residues.