Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Neethan A. Lobo"'
Autor:
Shaheen S. Sikandar, Angera H. Kuo, Tomer Kalisky, Shang Cai, Maider Zabala, Robert W. Hsieh, Neethan A. Lobo, Ferenc A. Scheeren, Sopheak Sim, Dalong Qian, Frederick M. Dirbas, George Somlo, Stephen R. Quake, Michael F. Clarke
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tu
Externí odkaz:
https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c
Autor:
Anjan Bharadwaj, Feiqiao Brian Yu, Robert W. Hsieh, Gunsagar S. Gulati, Aaron M. Newman, Dalong Qian, Ferenc A. Scheeren, Shang Cai, Frederick M. Dirbas, Daniel J. Wesche, Mark J. Berger, Francisco Ilagan, Michael F. Clarke, Angera H. Kuo, Maider Zabala, Neethan A. Lobo, Shaheen S. Sikandar, Anoop Manjunath
Publikováno v:
Science
Science, 367(6476), 405-+. AMER ASSOC ADVANCEMENT SCIENCE
Science, 367(6476), 405-+. AMER ASSOC ADVANCEMENT SCIENCE
Single-cell RNA-sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and direction of differentiation without prior knowledge has remained challenging. Here we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec50de330c26eb0f3f81a6f23c728afe
https://europepmc.org/articles/PMC7694873/
https://europepmc.org/articles/PMC7694873/
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-8 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Recent studies in murine mammary tissue have identified functionally distinct cell populations that may be isolated by surface phenotype or lineage tracing. Previous groups have shown that CD24medCD49fhigh cells enriched for long-lived mam
Autor:
Maider Zabala, Linus Li, Angera H. Kuo, Sopheak Sim, Luuk S. Heitink, Jane Antony, Michael F. Clarke, Gunsagar S. Gulati, Kassandra Sanchez, Dalong Qian, Aaron M. Newman, Maddalena Adorno, Natesh Parashurama, Jessica Lam, George Somlo, Tomer Kalisky, Neethan A. Lobo, Shaheen S. Sikandar, Stephen R. Quake, Frederick M. Dirbas
Publikováno v:
Cell Stem Cell. 27:284-299.e8
SMAD pathways govern epithelial proliferation, and transforming growth factor β (TGF-β and BMP signaling through SMAD members has distinct effects on mammary development and homeostasis. Here, we show that LEFTY1, a secreted inhibitor of NODAL/SMAD
Autor:
Neethan A. Lobo, Sopheak Sim, Tomer Kalisky, Shang Cai, George Somlo, Dalong Qian, Angera H. Kuo, Shaheen S. Sikandar, Michael F. Clarke, Stephen R. Quake, Ferenc A. Scheeren, Frederick M. Dirbas, Maider Zabala, Robert W. Hsieh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, 8
Nature Communications
Nature Communications, 8
Nature Communications
Previous studies have proposed that epithelial to mesenchymal transition (EMT) in breast cancer cells regulates metastasis, stem cell properties and chemo-resistance; most studies were based on in vitro culture of cell lines and mouse transgenic canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbb5f5f9e413746df11c19c8a5a0b72
https://hdl.handle.net/1887/95636
https://hdl.handle.net/1887/95636
Autor:
Andrew McGeehan, Joselyn R. Del Rosario, Young K. Chen, Lihong Shi, James M. Veal, Michael S. Weiss, David J. Hosfield, Alessandro Cuomo, Neethan A. Lobo, Jennifer Matuszkiewicz, Shih Chu Kao, Jeffrey A. Stafford, Tiziana Bonaldi, Michael Brennan Wallace, Natalie Y. Yuen, Ryan Stansfield, Shawn M. O'Connell, Chon Lai, Toufike Kanouni
Publikováno v:
ACS medicinal chemistry letters. 8(8)
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The mo
Cancer cells within tumors differ in phenotype, genetic and epigenetic modifications and functions. In an increasing number of tumors, a proliferative hierarchy has been defined where a subpopulation of cells possesses self-renewal potential, similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c556046fdf7da8f621497e3df0b31b1
https://doi.org/10.1016/b978-0-12-803892-5.00002-4
https://doi.org/10.1016/b978-0-12-803892-5.00002-4
Autor:
Lauren Agro, Shideng Bao, Chi-Hsuan Chang, Keith Syson Chan, Samuel H. Cheshier, Avijeet S. Chopra, Anastasia Chumakova, Michael F. Clarke, Salvatore Condello, Leanne R. Donahue, Rogelio Esparza, Fang Fang, Christine Fillmore Brainson, Austin Gurney, Andrew Haller, Jennifer Haynes, Diane Heiser, Joy Q. He, Masahiro Hitomi, Timothy Hoey, Jason K. Hseih, Gregor Hutter, Awad Jarrar, Carla F. Kim, Molly Kozminsky, Antonina V. Kurtova, Justin D. Lathia, Cherry Leung, Evelyne Lima-Fernandes, Huiping Liu, Xia Liu, Neethan A. Lobo, Daniela Matei, Siddhartha S. Mitra, Hyeongsun Moon, Sunitha Nagrath, Kenneth P. Nephew, Catherine A. O’Brien, Claudia Petritsch, Akshita Puri, Dalong Qian, Sumaiyah Rehman, Ofer Reizes, Jeffrey M. Rosen, Kiera Rycaj, Yogen Saunthararajah, Xiling Shen, Andrew E. Sloan, Benjamin T. Spike, Swetha J. Sundar, Dean G. Tang, Praveena S. Thiagarajan, Linda J. van Weele, Yadong Wang, Yinu Wang, Irving Weissman, Andrew C. White, James Wright, Maider Zabala, Wenchao Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2223cb4e4a70949237b56af2419b44c6
https://doi.org/10.1016/b978-0-12-803892-5.01002-0
https://doi.org/10.1016/b978-0-12-803892-5.01002-0
Autor:
Maider Zabala, Jose A. Seoane, Shaheen S. Sikandar, Luuk S. Heitink, Michael F. Clarke, Jessica Lam, Rudolf Jaenisch, Curtis Christina, Shang Cai, Neethan A. Lobo, Ferenc A. Scheeren, Frederick M. Dirbas, Debashis Sahoo, Shigeo Hisamori, Nicholas Watanabe, Sonia Antoñana, Yohei Shimono, George Somlo, Dalong Qian, Mark A. Zarnegar, Taichi Isobe, Yonatan Stelzer, An V. Luong, Angera H. Kuo
Publikováno v:
Molecular Cancer Research. 16:B67-B67
DNA methylation changes are common in cancers, but their consequences are not fully understood. The DLK1-DIO3 locus, whose transcripts are controlled by the imprinted control region IG-DMR, is hypomethylated in 8% of breast cancer patients. Moreover,
Autor:
Irene Wapnir, Frederick M. Dirbas, George Somlo, Tomer Kalisky, Michael J. Kaplan, Mary Jo Dorie, Maximilian Diehn, Manzhi Wong, Dalong Qian, Stephen R. Quake, Sean K. Lau, Robert W. Cho, Neethan A. Lobo, J. Martin Brown, Jeannie Shen, Irving L. Weissman, Laurie Ailles, Benzion Joshua, Carlos A. Garberoglio, Jessica Lam, Angela N. Kulp, Benjamin Paz, Michael F. Clarke
Publikováno v:
Nature. 458:780-783
Metabolism of oxygen, while central to life, also produces reactive oxygen species (ROS) that have been implicated in processes as diverse as cancer, cardiovascular disease, and aging. It has recently been shown that central nervous system stem cells