Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Neeta S. Roy"'
Publikováno v:
Eyecontact lens. 48(9)
To determine effect of omega-3 supplementation on conjunctival cell HLA-DR expression and tear concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17A, interferon-γ, and tumor necrosis factor-α in dry eye disease patients in the Dry Eye A
Publikováno v:
British Journal of Ophthalmology. :bjo-2022
Background/aimsTo compare dry eye disease (DED) signs and symptoms between men and women, as well as between premenopausal and postmenopausal women, in the Dry Eye Assessment and Management (DREAM) study.Methods434 women and 101 men self-reported pri
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Biomarkers with minimally invasive and reproducible objective metrics provide the key to future paradigm shifts in understanding of the underlying causes of dry eye disease (DED) and approaches to treatment of DED. We review biomarkers and th
Autor:
Neeta S. Roy, Fraser J. Sim, Steven A. Goldman, Dong Kyu Kim, H. Michael Keyoung, Hee-Won Jung, James E. Goldman
Publikováno v:
The Journal of Neuroscience. 26:12544-12555
Central neurocytoma (CN) is a rare periventricular tumor, whose derivation, lineage potential, and molecular regulation have been mostly unexplored. We noted that CN cells exhibited an antigenic profile typical of neuronal progenitor cellsin vivo, ye
Publikováno v:
Nature Medicine. 12:1259-1268
To direct human embryonic stem (HES) cells to a dopaminergic neuronal fate, we cocultured HES cells that were exposed to both sonic hedgehog and fibroblast growth factor 8 with telomerase-immortalized human fetal midbrain astrocytes. These astrocytes
Autor:
Neeta S. Roy, Webster H. Pilcher, Fraser J. Sim, Karen Chandross, Jennifer K Lang, Ben Waldau, Theodore E. Schwartz, Sridaran Natesan, Jean Merrill, Steven A. Goldmanm
Publikováno v:
Annals of Neurology. 59:763-779
Objective: Glial progenitor cells are abundant in adult human white matter. This study was designed to identify signaling pathways regulating their self-renewal and fate. Methods: We compared the transcriptional profiles of freshly sorted adult human
Autor:
Martha S. Windrem, Neeta S. Roy, Robert A Goodman, Marta Nunes, Steven A. Goldman, Guy M. McKhann, William K. Rashbaum, Theodore H. Schwartz
Publikováno v:
Nature Medicine. 10:93-97
Both late-gestation and adult human forebrain contain large numbers of oligodendrocyte progenitor cells (OPCs). These cells may be identified by their A2B5(+)PSA-NCAM(-) phenotype (positive for the early oligodendrocyte marker A2B5 and negative for t
Autor:
Amer Samdani, Steven A. Goldman, Abdellatif Benraiss, Eva Chmielnicki, H. Michael Keyoung, Martha S. Windrem, Neeta S. Roy, Marta Nunes
Publikováno v:
Clinical Neuroscience Research. 2:70-79
Neural precursor cells are dispersed widely throughout the adult brain. A population of multipotential progenitor cells, capable of giving rise to both neurons and glia, lines the cerebral ventricles of all adult animals, including humans. In additio
Identification and characterization of neuronal precursors and their progeny from human fetal tissue
Autor:
Tahmina Mujtaba, David R. Piper, Mary T. Lucero, Mahendra S. Rao, Hansoo Michael Keyoung, Steven A. Goldman, Neeta S. Roy
Publikováno v:
Journal of Neuroscience Research. 66:356-368
We have examined primary human neuronal precursors (HNPs) from 18-22-week-old fetuses. We showed that E-NCAM/MAP2/beta-III tubulin-immunoreactive neuronal precursors divide in vitro and could be induced to differentiate into mature neurons in 2 weeks
Autor:
Neeta S. Roy, Abdellatif Benraiss, Su Wang, Richard A.R. Fraser, Robert Goodman, William T. Couldwell, Maiken Nedergaard, Ayano Kawaguchi, Hideyuki Okano, Steven A. Goldman
Publikováno v:
Journal of Neuroscience Research. 59:321-331
Adult humans, like their nonhuman mammalian counterparts, harbor persistent neural progenitor cells in the forebrain ventricular lining. In the absence of adequate surface markers, however, these cells have proven difficult to isolate for study. We h