Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Neeru M. Sharma"'
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-16 (2020)
Abstract Background Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis. Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diuresis and natriuresis a
Externí odkaz:
https://doaj.org/article/bf4dd5329bf046f08c53757d81618fdb
Autor:
Andréa S. Haibara, Neeru M. Sharma, Hong Zheng, Xuefei Liu, Kenichi Katsurada, Shyam Sundar Nandi, Kaushik P. Patel
Publikováno v:
Hypertension. 77:147-157
Central infusion of Ang II (angiotensin II) has been associated with increased sympathetic outflow resulting in neurogenic hypertension. In the present study, we appraised whether the chronic increase in central Ang II activates the paraventricular n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd7b584c103159a7818a9c6e46c4fc2
https://doi.org/10.1161/hypertensionaha.120.16002
https://doi.org/10.1161/hypertensionaha.120.16002
Autor:
Kenichi Katsurada, Sushil K. Mahata, Kaushik P. Patel, Shyam Sundar Nandi, Neeru M. Sharma, Daniel R. Anderson
Publikováno v:
Am J Physiol Heart Circ Physiol
Increased matrix metalloprotease 9 (MMP9) after myocardial infarction (MI) exacerbates ischemia-induced chronic heart failure (CHF). Autophagy is cardioprotective during CHF; however, whether increased MMP9 suppresses autophagic activity in CHF is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8013ed3be80ac4c0df2539306c00a035
https://doi.org/10.1152/ajpheart.00032.2020
https://doi.org/10.1152/ajpheart.00032.2020
Publikováno v:
Nitric Oxide
Activation of renin-angiotensin- system, nitric oxide (NO•) bioavailability and subsequent sympathoexcitation plays a pivotal role in the pathogenesis of many cardiovascular diseases, including hypertension. Previously we have shown increased prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52e8fffcb05e4c1b69eb09407e07bc3
https://doi.org/10.1016/j.niox.2019.10.007
https://doi.org/10.1016/j.niox.2019.10.007
Publikováno v:
Circ Heart Fail
Background: Recent clinical studies demonstrate that SGLT2 (sodium-glucose cotransporter 2) inhibitors ameliorate heart failure (HF). The present study was conducted to assess the expression and function of renal SGLT2 and the influence of enhanced r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb690c6f70ac6bc7fac378b9c815300
https://europepmc.org/articles/PMC8692398/
https://europepmc.org/articles/PMC8692398/
Autor:
Neeru M. Sharma, Kaushik P. Patel, Xuefei Liu, Hong Zheng, Kenichi Katsurada, Shyam Sundar Nandi
Publikováno v:
Am J Physiol Renal Physiol
Glucagon-like peptide-1 (GLP-1), an incretin hormone, has diuretic and natriuretic effects. The present study was designed to explore the possible underlying mechanisms for the diuretic and natriuretic effects of GLP-1 via renal nerves in rats. Immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb8770c2beb88f8d9dcea6709bb7d45
https://doi.org/10.1152/ajprenal.00028.2019
https://doi.org/10.1152/ajprenal.00028.2019
Autor:
Toshihiko Yada, Yuko Maejima, Neeru M. Sharma, Boyang Zhang, Masanori Nakata, Kazuomi Kario, Kenichi Katsurada, Toshinobu Saito, Kaushik K. Patel, Shyam Sundar Nandi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used to treat type 2 diabetes, reduce blood pressure (BP) in hypertensive patients. Whether this action involves central mechanisms is unknown. We here report that repeated lateral ventricula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a6a4f46e354de5c241a993b0355a9a
http://link.springer.com/article/10.1038/s41598-019-49364-x
http://link.springer.com/article/10.1038/s41598-019-49364-x
Publikováno v:
Advances in Physiology Education. 43:175-179
Scientific advocacy and outreach programs are encouraged to increase public understanding of scientific knowledge and generate interest in science, technology, engineering, and mathematics (STEM) careers. However, evaluation of these events’ effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fae5f7767082a20f2fb85df870e7963
https://doi.org/10.1152/advan.00013.2019
https://doi.org/10.1152/advan.00013.2019
Publikováno v:
Circulation. 142
Introduction: Diastolic dysfunction and cardiac hypertrophic remodeling are hallmark features of heart failure with preserved ejection fraction (HFpEF) in humans. However, an ideal animal model that mimics all these basic clinical features of HFpEF r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae9bdd110b4bd6cfa88909698eb264b
https://doi.org/10.1161/circ.142.suppl_3.16639
https://doi.org/10.1161/circ.142.suppl_3.16639
Autor:
Andrea Siqueira Haibara, Shyam Sundar Nandi, Kaushik P Patel, Kenichi Katsurada, Neeru M. Sharma
Publikováno v:
Hypertension. 76
Central activation of the renin-angiotensin system and subsequent sympathoexcitation plays a pivotal role in the pathogenesis of hypertension. The specific neural substrates and the possible molecular mechanisms for the sympathoexcitation remain uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ed280bd1f7cbbfdef384b2fed5f2fa
https://doi.org/10.1161/hyp.76.suppl_1.mp49
https://doi.org/10.1161/hyp.76.suppl_1.mp49