Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Neerja, Karnani"'
Autor:
Joanna Hui Juan Tan, Zhihui Li, Mar Gonzalez Porta, Ramesh Rajaby, Weng Khong Lim, Ye An Tan, Rodrigo Toro Jimenez, Renyi Teo, Maxime Hebrard, Jack Ling Ow, Shimin Ang, Justin Jeyakani, Yap Seng Chong, Tock Han Lim, Liuh Ling Goh, Yih Chung Tham, Khai Pang Leong, Calvin Woon Loong Chin, SG10K_Health Consortium, Sonia Davila, Neerja Karnani, Ching-Yu Cheng, John Chambers, E. Shyong Tai, Jianjun Liu, Xueling Sim, Wing Kin Sung, Shyam Prabhakar, Patrick Tan, Nicolas Bertin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little know
Externí odkaz:
https://doaj.org/article/bb56de9b54524700a6c80797234f227e
Autor:
Jia Xu, Rebbeca M. Duar, Baoling Quah, Min Gong, Felicia Tin, Penny Chan, Choon Kiat Sim, Kok Hian Tan, Yap Seng Chong, Peter D. Gluckman, Steven A. Frese, David Kyle, Neerja Karnani
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
BackgroundThe loss of ancestral microbes, or the “disappearing microbiota hypothesis” has been proposed to play a critical role in the rise of inflammatory and immune diseases in developed nations. The effect of this loss is most consequential du
Externí odkaz:
https://doaj.org/article/cd73a66061894219b3db25b76b10a3d3
Autor:
Mary C. Stephenson, Jamie X.M. Ho, Eugenia Migliavacca, Maria Kalimeri, Neerja Karnani, Subhasis Banerji, John J. Totman, Jerome N. Feige, Reshma A. Merchant, Stacey K.H. Tay
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1482-1494 (2023)
Abstract Background Mitochondrial dysfunction has been implicated in sarcopenia. 31P magnetic resonance spectroscopy (MRS) enables non‐invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we as
Externí odkaz:
https://doaj.org/article/db4a386da10847ff80503a8a94989940
Autor:
Li Chen, Sartaj Ahmad Mir, Anne K. Bendt, Esther W. L. Chua, Kothandaraman Narasimhan, Karen Mei-Ling Tan, See Ling Loy, Kok Hian Tan, Lynette P. Shek, Jerry Chan, Fabian Yap, Michael J. Meaney, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Neerja Karnani, Markus R. Wenk
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-24 (2023)
Abstract Background Adaptations in lipid metabolism are essential to meet the physiological demands of pregnancy and any aberration may result in adverse outcomes for both mother and offspring. However, there is a lack of population-level studies to
Externí odkaz:
https://doaj.org/article/679f327d8a4d4d44a9bb74f4acdd4ab7
Autor:
Sock Hoai Chan, Yasmin Bylstra, Jing Xian Teo, Jyn Ling Kuan, Nicolas Bertin, Mar Gonzalez-Porta, Maxime Hebrard, Roberto Tirado-Magallanes, Joanna Hui Juan Tan, Justin Jeyakani, Zhihui Li, Jin Fang Chai, Yap Seng Chong, Sonia Davila, Liuh Ling Goh, Eng Sing Lee, Eleanor Wong, Tien Yin Wong, SG10K_Health Consortium, Shyam Prabhakar, Jianjun Liu, Ching-Yu Cheng, Birgit Eisenhaber, Neerja Karnani, Khai Pang Leong, Xueling Sim, Khung Keong Yeo, John C. Chambers, E-Shyong Tai, Patrick Tan, Saumya S. Jamuar, Joanne Ngeow, Weng Khong Lim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Clinically significant genetic variation in Asian populations is under-characterized. Here, the authors show the diversity in prevalence and spectrum of human disease and pharmacogenetic variants in a multi-ethnic Asian population.
Externí odkaz:
https://doaj.org/article/117b09c793b9435cbcba4527a4883feb
Autor:
Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Adam Alexander T. Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Kevin Huynh, Corey Giles, Ding Mei, Gerard Wong, Fabian Yap, Kok Hian Tan, Fiona Collier, Richard Saffery, Peter Vuillermin, Anne K. Bendt, David Burgner, Anne-Louise Ponsonby, Yung Seng Lee, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Peter J. Meikle, Markus R. Wenk, Neerja Karnani
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Lipids play a vital role in health and disease, but changes to their circulating levels and the link with obesity remain poorly characterized in expecting mothers and their offspring in early childhood. Methods LC-MS/MS-based quan
Externí odkaz:
https://doaj.org/article/2a524f4cbd2448029ad0b8261c9144bb
Autor:
Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Nicolas Bertin, Maxime Hebrard, Chiea Chuen Khor, Zheng Li, Joanna Hui Juan Tan, Wee Yang Meah, Su Qin Peh, Shi Qi Mok, Kar Seng Sim, Jianjun Liu, Ling Wang, Eleanor Wong, Jingmei Li, Aung Tin, Ching-Yu Cheng, Chew-Kiat Heng, Jian-Min Yuan, Woon-Puay Koh, Seang Mei Saw, Yechiel Friedlander, Xueling Sim, Jin Fang Chai, Yap Seng Chong, Sonia Davila, Liuh Ling Goh, Eng Sing Lee, Tien Yin Wong, Neerja Karnani, Khai Pang Leong, Khung Keong Yeo, John C. Chambers, Su Chi Lim, Rick Siow Mong Goh, Patrick Tan, Rajkumar Dorajoo
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106546- (2023)
Summary: Genomic researchers increasingly utilize commercial cloud service providers (CSPs) to manage data and analytics needs. CSPs allow researchers to grow Information Technology (IT) infrastructure on demand to overcome bottlenecks when combining
Externí odkaz:
https://doaj.org/article/3a05ca171fb2408194c45da5d91f3fb5
Autor:
Li Chen, Karen Tan Mei Ling, Min Gong, Mary F. F. Chong, Kok Hian Tan, Yap Seng Chong, Michael J. Meaney, Peter D. Gluckman, Johan G. Eriksson, Neerja Karnani
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Telomere length (TL) and its attrition are important indicators of physiological stress and biological aging and hence may vary among individuals of the same age. This variation is apparent even in newborns, suggesting potential e
Externí odkaz:
https://doaj.org/article/f773bd804fd14d6893d96f568754da2f
Autor:
Jonathan Yinhao Huang, Shirong Cai, Zhongwei Huang, Mya Thway Tint, Wen Lun Yuan, Izzuddin M. Aris, Keith M. Godfrey, Neerja Karnani, Yung Seng Lee, Jerry Kok Yen Chan, Yap Seng Chong, Johan Gunnar Eriksson, Shiao-Yng Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Huang and colleagues used machine-learning estimators to analyse a broad range of parameters in a prospective cohort consisting ART and spontaneously conceived children. Small differences in stature and growth could not be explained by parental or pe
Externí odkaz:
https://doaj.org/article/0dcc6959279147e19b2fae8d5e9574cb
Autor:
Elie Antoun, Eugenia Migliavacca, Emma S Garratt, Sheila J Barton, Phil Titcombe, Leo D Westbury, Alica Baczynska, Richards Dodds, Helen C Roberts, Avan A Sayer, Sarah Shaw, H.E. Syddall, Allan Sheppard, Craig McFarlane, Neerja Karnani, Terrence Forrester, Cyrus Cooper, Jerome N Feige, Harnish P Patel, Keith M Godfrey, Karen A Lillycrop, the EpiGen Global Research Consortium
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 2, Pp 207-221 (2021)
Abstract Background Despite increasing knowledge of the pathogenesis of muscle ageing, the molecular mechanisms are poorly understood. Based on an expression analysis of muscle biopsies from older Caucasian men, we undertook an in‐depth analysis of
Externí odkaz:
https://doaj.org/article/a5b9c209ed974c5ab4dd714c72918127