Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Neeraj Shakya"'
Publikováno v:
Pharmaceuticals, Vol 5, Iss 7, Pp 690-718 (2012)
Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculos
Externí odkaz:
https://doaj.org/article/84ca5e3746624dfaacd4230e25a81d48
Autor:
Neeraj Shakya, Saurabh Garg, Babita Agrawal, Naveen C. Srivastav, Dennis Kunimoto, Rakesh K. Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5521-5533
The resurgence of mycobacterial infections and the emergence of drug-resistant strains urgently require a new class of agents that are distinct than current therapies. A group of 5-ethynyl ( 6 – 10 ), 5-(2-propynyloxy) ( 16 , 18 , 20 , 22 , 24 ), 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba84cd1cceeabd60c8d8128d101c7ea8
https://doi.org/10.1016/j.bmc.2016.09.008
https://doi.org/10.1016/j.bmc.2016.09.008
Publikováno v:
Letters in Drug Design & Discovery. 11:917-921
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e9b4a284250a63832eabefd1de3cbf0
https://doi.org/10.2174/1570180811666140401184856
https://doi.org/10.2174/1570180811666140401184856
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 5, Iss 7, Pp 690-718 (2012)
Pharmaceuticals, Vol 5, Iss 7, Pp 690-718 (2012)
Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688f5c216750b128e451eae9be69c74d
http://europepmc.org/articles/PMC3763665
http://europepmc.org/articles/PMC3763665
Autor:
Sudha Bhavanam, Dennis Kunimoto, Rakesh Kumar, Amogh Agrawal, Naveen C. Srivastav, Neeraj Shakya, Nancy Desroches, Chris Tse
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1091-1094
Several 5-alkyl (or halo)-3′-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis , Mycobacterium tuberculosis and Mycobacterium avium . Among these compounds, 3′-azido-5-ethyl-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e9b19d23a6c0c0b26bd8e24bfb24b7
https://doi.org/10.1016/j.bmcl.2011.11.114
https://doi.org/10.1016/j.bmcl.2011.11.114
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1407-1409
Hepatitis C virus (HCV) infection is one of the major health problems worldwide. If left untreated, it leads to liver cirrhosis, liver cancer and death. Herein, we report synthesis and anti-HCV activity of a new class of pyrimidine nucleosides posses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878f78fbd75bc4c3c39534596c91d488
https://doi.org/10.1016/j.bmcl.2014.01.024
https://doi.org/10.1016/j.bmcl.2014.01.024
Autor:
Chao Liang, Neeraj Shakya, Naveen C. Srivastav, Michelle W. Mak, Babita Agrawal, Rakesh K. Kumar, D. Lorne Tyrrell
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:7542-7547
Chronic infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) lead to serious liver diseases worldwide. Co-infection with HBV and HCV is very common and is associated with increased risk of liver pathogenesis, liver cancer, and liver fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cbde007916ccde1bc44a9c8ae08ce6
https://doi.org/10.1016/j.bmc.2010.08.048
https://doi.org/10.1016/j.bmc.2010.08.048
Autor:
Michelle W. Mak, Babita Agrawal, D. Lorne Tyrrell, Naveen C. Srivastav, Rakesh Kumar, Neeraj Shakya
Publikováno v:
Journal of Medicinal Chemistry. 53:7156-7166
Despite the existence of successful vaccine and antiviral therapies, infection with hepatitis B virus (HBV) continues to be a major global cause of acute and chronic liver disease and high mortality. We synthesized and evaluated several lyxofuranosyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4613061eee278d470d8bb998ca3a8c8
https://doi.org/10.1021/jm100803c
https://doi.org/10.1021/jm100803c
Autor:
Naveen C. Srivastav, Rakesh Kumar, Babita Agrawal, Dennis Kunimoto, Nancy Desroches, Neeraj Shakya
Publikováno v:
Journal of Medicinal Chemistry. 53:4130-4140
Tuberculosis (TB) is a major health problem worldwide. We herein report a new class of pyrimidine nucleosides as potent inhibitors of Mycobacterium tuberculosis (M. tuberculosis). Various 2'- or 3'-halogeno derivatives of pyrimidine nucleosides conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499f3f8fb5e61f38889b32e7a9cc0743
https://doi.org/10.1021/jm100165w
https://doi.org/10.1021/jm100165w
Publikováno v:
Medicinal Chemistry Research. 13:812-823
α-Adrenergic receptors (ARs) are of current medicinal interest. In order to identify the essential structural and physicochemical requirements in term of common biophoric sites and secondary sites for binding with α1a-adrenergic receptors, a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::346915855e2531cfa7cd144853af82f1
https://doi.org/10.1007/s00044-004-0120-9
https://doi.org/10.1007/s00044-004-0120-9