Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Neeraj Kumar Aryal"'
Autor:
Jamal Carlos Saeh, Justin Cidado, Lisa Drew, Stephen Fawell, Michelle Min Wu, Neeraj Kumar Aryal, Gareth P. Gregory, Maureen Hattersley, Wenlin Shao, Theresa Proia, Maryann San Martin, Ricky W. Johnstone, Scott Boiko
Publikováno v:
Blood
BH3 mimetics like venetoclax target prosurvival Bcl-2 family proteins and are important therapeutics in the treatment of hematological malignancies. We demonstrate that endogenous Bfl-1 expression can render preclinical lymphoma tumor models insensit
Autor:
Lisa Drew, Huayang Liu, Miika Ahdesmaki, Stephen Fawell, Scott Boiko, Anjana Sundarrajan, Ultan McDermott, Neeraj Kumar Aryal, Lawrence H. Boise, David W. Jenkins, Justin Cidado, Andrew F. Jarnuczak, Eric Miele, Aurélie Bornot
Publikováno v:
Blood. 138:2275-2275
Evasion of apoptosis is a hallmark of cancer wherein overexpression and amplification of pro-survival BCL2-family genes like MCL1 is a common observation. MCL1 is frequently amplified in many hematological cancers like Multiple Myeloma (MM) that depe